Comparison of two routes of administration of a cationic liposome formulation for a prophylactic DC vaccination in a murine melanoma model

Autor: Alexander Seifalian, Ali Badiee, Nema Mohamadian Roshan, Mona Yazdani, Amin Reza Nikpoor, Zahra Gholizadeh, Mahmoud Reza Jaafari

Publikováno v: International immunopharmacology. 98

Dendritic cell (DC) vaccination can be achieved via straight loading of vaccine into DCs ex vivo or administration to DCs in vivo. However, there is no certain consensus on which approach is preferable, and each strategy has its advantages and disadv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ac160e79f58a12c6cfa4d0007e2e30
https://pubmed.ncbi.nlm.nih.gov/34352472

Comparison of intradermal injection and epicutaneous laser microporation for antitumor vaccine delivery in a human skin explant model

Autor: Dorian A. Stolk, Hakan Kalay, Martino Ambrosini, Jana Vree, van Kooyk Y, Sanne Duinkerken, Joyce Lübbers

Publikováno v: Biorxiv. Cold Spring Harbor Laboratory Press
Biorxiv
Duinkerken, S, Lübbers, J, Stolk, DA, Vree, J, Ambrosini, M, Kalay, H & van Kooyk, Y 2019, ' Comparison of intradermal injection and epicutaneous laser microporation for antitumor vaccine delivery in a human skin explant model ', Biorxiv . https://doi.org/10.1101/861930

Human skin is a prime vaccination site containing multiple antigen presenting cells (APC), including Langerhans cells (LC) and dendritic cells (DC). APC deliver antigens to lymph nodes for induction of adaptive immunity through stimulating antigen sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003630b367880007a9ba7bcc9a66c38f
https://doi.org/10.1101/861930

An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells

Autor: Hakim Echchannaoui, Ugur Sahin, Philippe Guillaume, Sebastian Klobuch, Simone Thomas, Matthias Birtel, Ralf-Holger Voss, Hans J. Stauss, Tana Omokoko, Matthias Theobald, Wolfgang Herr, Pedro Romero, Oezlem Yildiz, Diana Knies, Shao-An Xue

Publikováno v: Oncotarget, vol. 7, no. 16, pp. 21199-21221
Oncotarget

Immunotherapy of cancer envisions the adoptive transfer of T-cells genetically engineered with tumor-specific heterodimeric α/β T-cell receptors (TCRα/β). However, potential mispairing of introduced TCRα/β-chains with endogenous β/α-ones may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553f9a4046c7946242049cbaddf95f14
https://doi.org/10.18632/oncotarget.8385

Redirected T cell lysis in patients with metastatic uveal melanoma with gp100-directed TCR IMCgp100: Overall survival findings

Autor: Paul Nathan, Leonel Hernandez-Aya, Marlana Orloff, Nicola Little, Jennifer Visich, Ann-Marie Hulstine, Joseph J. Sacco, Christina M. Coughlin, Takami Sato, Richard D. Carvajal

Publikováno v: Journal of Clinical Oncology. 36:9521-9521

9521Background: IMCgp100 is a bispecific biologic comprised of a soluble T cell receptor recognizing the gp100 antigen fused to a scFV anti-CD3 and redirects T cell lysis of melanoma cells expressi...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::901dc9fc54ac4c9954f6baca0d9d8843
https://doi.org/10.1200/jco.2018.36.15_suppl.9521

Immune selection after antigen-specific immunotherapy of melanoma

Autor: Ena Wang, Steven A. Rosenberg, Udai S. Kammula, Patricia Fetsch, Andrea Abati, Janice N. Cormier, Adam I. Riker, Seth M. Steinberg, Kang Hun Lee, Monica C. Panelli, Francesco M. Marincola

Publikováno v: Surgery. 126:112-120

Background: Melanoma antigen (MA)–specific vaccination strongly enhances antitumor reactivity in vivo and is capable of producing strong cytotoxic T lymphocyte responses in vitro. Furthermore, specific human leukocyte antigen–restricted T cell ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::904d98226d60f1430b3cdface033e2a2
https://doi.org/10.1016/s0039-6060(99)70143-1