Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Gowrishankar, Muthukrishnan"'
Publikováno v:
Antibiotics, Vol 13, Iss 7, p 640 (2024)
Bacterial infections continue to represent a significant healthcare burden worldwide, causing considerable mortality and morbidity every year. The emergence of multidrug-resistant bacterial strains continues to rise, posing serious risks to controlli
Externí odkaz:
https://doaj.org/article/02e2b8b15a424cd090d5a665b6a69168
Autor:
H. Mark Kenney, Javier Rangel-Moreno, Yue Peng, Kiana L. Chen, Jennifer Bruno, Abdul Embong, Elizabeth Pritchett, Jeffrey I. Fox, Enrique Becerril-Villanueva, Armando Gamboa-Domínguez, Sally Quataert, Gowrishankar Muthukrishnan, Ronald W. Wood, Benjamin D. Korman, Jennifer H. Anolik, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz, Chia-Lung Wu
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionDefective lymphatic drainage and translocation of B-cells in inflamed (Bin) joint-draining lymph node sinuses are pathogenic phenomena in patients with severe rheumatoid arthritis (RA). However, the molecular mechanisms underlying this ly
Externí odkaz:
https://doaj.org/article/60bcac2b046f4b6fa2b4cb7c08b2c6e3
Autor:
Yugo Morita, Motoo Saito, Javier Rangel-Moreno, Anthony M. Franchini, John R. Owen, John C. Martinez, John L. Daiss, Karen L. de Mesy Bentley, Stephen L. Kates, Edward M. Schwarz, Gowrishankar Muthukrishnan
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-12 (2022)
Abstract Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain controversial, and its role in patients with S. aureus osteomyelitis is unknown. To address this knowledge gap, we completed a clinical study and obs
Externí odkaz:
https://doaj.org/article/225a91035f104c71992dd36009af973e
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
The gut microbiota regulates multiple facets of host metabolism and immunity through the production of signaling metabolites, such as polyamines which are small organic compounds that are essential to host cell growth and lymphocyte activation. Polya
Externí odkaz:
https://doaj.org/article/efdc7a54e6cd45529325f82442dfa9fa
Autor:
Shardulendra Prasad Sherchand, Rajan P. Adhikari, Gowrishankar Muthukrishnan, Tulasikumari Kanipakala, John R. Owen, Chao Xie, M. Javad Aman, Richard A. Proctor, Edward M. Schwarz, Stephen L. Kates
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Staphylococcus aureus osteomyelitis remains a very challenging condition; recent clinical studies have shown infection control rates following surgery/antibiotics to be ~60%. Additionally, prior efforts to produce an effective S. aureus vaccine have
Externí odkaz:
https://doaj.org/article/86befead12a24ee4bec39e7017d85dbf
Autor:
Calvin L. Cole, John F. Bachman, Jian Ye, Joseph Murphy, Scott A. Gerber, Christopher A. Beck, Brendan F. Boyce, Gowrishankar Muthukrishnan, Joe V. Chakkalakal, Edward M. Schwarz, David Linehan
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 3, Pp 731-745 (2021)
Abstract Background Skeletal muscle wasting (SMW) in cancer patients is associated with increased morbidity, mortality, treatment intolerance and discontinuation, and poor quality of life. This is particularly true for patients with pancreatic ductal
Externí odkaz:
https://doaj.org/article/253d934b0fa14eca9e41eee1ebbe2db1
Autor:
Elysia A. Masters, Gowrishankar Muthukrishnan, Lananh Ho, Ann Lindley Gill, Karen L. de Mesy Bentley, Chad A. Galloway, James L. McGrath, Hani A. Awad, Steven R. Gill, Edward M. Schwarz
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Staphylococcus aureus invasion of the osteocyte lacuno-canalicular network (OLCN) is a novel mechanism of bacterial persistence and immune evasion in chronic osteomyelitis. Previous work highlighted S. aureus cell wall transpeptidase, penicillin bind
Externí odkaz:
https://doaj.org/article/9f13972546dd407aa4bcffa9929fcc8f
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Innate and adaptive immune responses against pathogens are known to be carefully orchestrated by specific cytokines that initiate and down regulate immune cell functions from the initial infection through tissue repair and homeostasis. However, some
Externí odkaz:
https://doaj.org/article/d22d3a273b9740549ea86f4252201e7a
Autor:
Gowrishankar Muthukrishnan, Alexandra Wallimann, Javier Rangel-Moreno, Karen L. de Mesy Bentley, Maria Hildebrand, Karen Mys, H. Mark Kenney, Eric T. Sumrall, John L. Daiss, Stephan Zeiter, R. Geoff Richards, Edward M. Schwarz, T. Fintan Moriarty
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Staphylococcus aureus is the predominant pathogen causing osteomyelitis. Unfortunately, no immunotherapy exists to treat these very challenging and costly infections despite decades of research, and numerous vaccine failures in clinical trials. This
Externí odkaz:
https://doaj.org/article/1c26744227374a40a0b800dfcdf3a279
Autor:
Matthew F. Lawrance, Gowrishankar Muthukrishnan, John Deichen, Michael Deichen, James Schaus, Alexander M. Cole, Christopher L. Parkinson
Publikováno v:
Journal of Infection and Public Health, Vol 11, Iss 5, Pp 648-656 (2018)
Background: Staphylococcus aureus has strong association with anthropogenic environments. This association has not been well supported by use of genetic tools. The aim of this study was to phylogenetically relate numerous isolates from three environm
Externí odkaz:
https://doaj.org/article/2bda67c141894a2c8ad0e420cdc9c236