Zobrazeno 1 - 10 of 143 pro vyhledávání: '"Gowers DM"'
1
Akademický článek
A Lambda-Exonuclease SELEX Method for Generating Aptamers to Bacterial Targets.
Autor: Gowland R; Biophysics Laboratories, School of Biological Sciences, University of Portsmouth, Portsmouth, UK., Gowers DM; Biophysics Laboratories, School of Biological Sciences, University of Portsmouth, Portsmouth, UK. darren.gowers@port.ac.uk.
Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2633, pp. 145-161.
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2
Akademický článek
Classical Recombinant DNA Cloning.
Autor: Mikić A; Biophysics Laboratories, School of Biological Sciences, University of Portsmouth, Portsmouth, UK., Alomari A; Biophysics Laboratories, School of Biological Sciences, University of Portsmouth, Portsmouth, UK.; Department of Basic Sciences, College of Agriculture and Forestry, University of Mosul, Mosul, Iraq., Gowers DM; Biophysics Laboratories, School of Biological Sciences, University of Portsmouth, Portsmouth, UK. darren.gowers@port.ac.uk.
Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2633, pp. 1-24.
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3
Akademický článek
An Investigation into the Potential of Targeting Escherichia coli rne mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy.
Autor: Goddard LR; School of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.; Centre for Enzyme Innovation, University of Portsmouth, Portsmouth PO1 2DY, UK., Mardle CE; School of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK., Gneid H; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01609, USA.; Department of Chemistry, University of Southampton, Southampton SO17 1BJ, UK., Ball CG; School of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.; Centre for Enzyme Innovation, University of Portsmouth, Portsmouth PO1 2DY, UK., Gowers DM; School of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK., Atkins HS; Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK.; College of Life and Environmental Sciences, University of Exeter, Exeter EX4 4QD, UK., Butt LE; School of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK., Watts JK; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01609, USA., Vincent HA; School of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.; Centre for Enzyme Innovation, University of Portsmouth, Portsmouth PO1 2DY, UK., Callaghan AJ; School of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.; Centre for Enzyme Innovation, University of Portsmouth, Portsmouth PO1 2DY, UK.
Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2021 Jun 04; Vol. 26 (11). Date of Electronic Publication: 2021 Jun 04.
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4
Akademický článek
Identification of Novel Inhibitors of Escherichia coli DNA Ligase (LigA).
Autor: Alomari A; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.; Department of Basic Sciences, College of Agriculture and Forestry, University of Mosul, Mosul 41002, Iraq., Gowland R; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK., Southwood C; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK., Barrow J; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK., Bentley Z; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK., Calvin-Nelson J; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK., Kaminski A; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK., LeFevre M; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK., Callaghan AJ; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK., Vincent HA; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK., Gowers DM; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.
Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2021 Apr 25; Vol. 26 (9). Date of Electronic Publication: 2021 Apr 25.
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5
Akademický článek
Allosteric inhibition of human exonuclease1 (hExo1) through a novel extended β-sheet conformation.
Autor: Umar AA; School of Biosciences, University of Nottingham Sutton Bonington Campus, Leicestershire LE12 5RD, United Kingdom; Department of Biochemistry, Kebbi State University of Science and Technology, Aliero, P.M.B 1144, Birnin Kebbi, Nigeria. Electronic address: au.argungu@ksusta.edu.ng., Liddell S; School of Biosciences, University of Nottingham Sutton Bonington Campus, Leicestershire LE12 5RD, United Kingdom., Hussain R; Diamond Light Source, Rutherford Appleton Laboratory, Oxfordshire OX11 0DE, United Kingdom., Siligardi G; Diamond Light Source, Rutherford Appleton Laboratory, Oxfordshire OX11 0DE, United Kingdom., Harris G; Research Complex at Harwell, Rutherford Appleton Laboratory, Oxfordshire OX11 0FA, United Kingdom., Carr S; Research Complex at Harwell, Rutherford Appleton Laboratory, Oxfordshire OX11 0FA, United Kingdom., Asiani K; School of Biosciences, University of Nottingham Sutton Bonington Campus, Leicestershire LE12 5RD, United Kingdom., Gowers DM; School of Biological Science, King Henry Building, King Henry 1(st) Street, Portsmouth, Hampshire PO1 2DY, United Kingdom., Odell M; Department of Life Sciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, United Kingdom., Scott DJ; School of Biosciences, University of Nottingham Sutton Bonington Campus, Leicestershire LE12 5RD, United Kingdom; Research Complex at Harwell, Rutherford Appleton Laboratory, Oxfordshire OX11 0FA, United Kingdom; ISIS Spallation Neutron and Muon source, Rutherford Appleton Laboratory, Oxfordshire OX11 0QX, United Kingdom.
Publikováno v: Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2020 Dec; Vol. 1864 (12), pp. 129730. Date of Electronic Publication: 2020 Sep 12.
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6
Akademický článek
Identification and analysis of novel small molecule inhibitors of RNase E: Implications for antibacterial targeting and regulation of RNase E.
Autor: Mardle CE; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom., Goddard LR; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom., Spelman BC; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom., Atkins HS; Defence Science and Technology Laboratory, Porton Down, Salisbury, United Kingdom.; University of Exeter, Exeter, United Kingdom.; London School of Hygiene and Tropical Medicine, London, United Kingdom., Butt LE; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom., Cox PA; School of Pharmacy and Biomedical Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT, United Kingdom., Gowers DM; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom., Vincent HA; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom., Callaghan AJ; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom.
Publikováno v: Biochemistry and biophysics reports [Biochem Biophys Rep] 2020 Jun 09; Vol. 23, pp. 100773. Date of Electronic Publication: 2020 Jun 09 (Print Publication: 2020).
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7
Akademický článek
A structural and biochemical comparison of Ribonuclease E homologues from pathogenic bacteria highlights species-specific properties.
Autor: Mardle CE; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom., Shakespeare TJ; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom., Butt LE; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom., Goddard LR; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom., Gowers DM; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom., Atkins HS; Defence Science and Technology Laboratory, Porton Down, Salisbury, United Kingdom.; University of Exeter, Exeter, United Kingdom.; London School of Hygiene and Tropical Medicine, London, United Kingdom., Vincent HA; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom. Helen.Vincent@port.ac.uk., Callaghan AJ; School of Biological Sciences and Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DY, United Kingdom. Anastasia.Callaghan@port.ac.uk.
Publikováno v: Scientific reports [Sci Rep] 2019 May 28; Vol. 9 (1), pp. 7952. Date of Electronic Publication: 2019 May 28.
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8
Akademický článek
Inhibition of homologous phosphorolytic ribonucleases by citrate may represent an evolutionarily conserved communicative link between RNA degradation and central metabolism.
Autor: Stone CM; School of Biological Sciences and Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK., Butt LE; School of Biological Sciences and Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK., Bufton JC; School of Biological Sciences and Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK., Lourenco DC; School of Biological Sciences and Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK., Gowers DM; School of Biological Sciences and Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK., Pickford AR; School of Biological Sciences and Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK., Cox PA; School of Pharmacy and Biomedical Sciences and Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK., Vincent HA; School of Biological Sciences and Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK., Callaghan AJ; School of Biological Sciences and Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK.
Publikováno v: Nucleic acids research [Nucleic Acids Res] 2017 May 05; Vol. 45 (8), pp. 4655-4666.
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9
Akademický článek
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