Výsledky vyhledávání - "Govindaswami Ragupathi"

Fully Synthetic Carbohydrate-Based Vaccines in Biochemically Relapsed Prostate Cancer: Clinical Trial Results With α-N-Acetylgalactosamine-O-Serine/Threonine Conjugate Vaccine

Autor: David Verbel, Samuel J. Danishefsky, Dalibor Sames, Susan F. Slovin, Govindaswami Ragupathi, Philip O. Livingston, Howard I. Scher, Cristina Musselli, Krystyna Olkiewicz, Scott D. Kuduk, Jacob B. Schwarz

Publikováno v: Journal of Clinical Oncology. 21:4292-4298

Purpose: We report the synthesis of a mucin-related O-linked glycopeptide, α-N-acetylgalactosamine-O-serine/threonine (Tn), which is highly simplistic in its structure and can induce a relevant humoral response when given in a trimer or clustered (c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf023e265e08b9698e95b6bc5893cb2
https://doi.org/10.1200/jco.2003.04.112

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Reevaluation of the cellular immune response in breast cancer patients vaccinated with MUC1

Autor: Yael Spinat, Teresa Gilewski, Govindaswami Ragupathi, Katherine S. Panageas, Philip O. Livingston, Cristina Musselli

Publikováno v: International Journal of Cancer. 97:660-667

Conjugation of antigens to a carrier protein like keyhole limpet hemocyanin (KLH) has proven effective in clinical trials for inducing antibodies against selected tumor antigens. The impact of this approach on T-cell immunity has not been previously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf85104fb5828ca323498f3c2340e52
https://doi.org/10.1002/ijc.10081

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Keyhole limpet hemocyanin conjugate vaccines against cancer: The Memorial Sloan Kettering experience

Autor: Philip O. Livingston, Govindaswami Ragupathi, Cristina Musselli

Publikováno v: Journal of Cancer Research and Clinical Oncology. 127:R20-R26

Passively administered and actively induced antibodies have been associated with the eradication of circulating tumor cells and micrometastases in mice and humans. We have identified a series of cell surface carbohydrate and peptide antigens on melan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d955b0e151e917107b52ae9f7e7b3d86
https://doi.org/10.1007/bf01470995

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A Second Generation Synthesis of the MBr1 (Globo-H) Breast Tumor Antigen: New Application of then-Pentenyl Glycoside Method for Achieving Complex Carbohydrate Protein Linkages

Autor: Jennifer R. Allen, Allen John Gordon, Andrzej Zatorski, Philip O. Livingston, Govindaswami Ragupathi, Xu-Feng Zhang, Samuel J. Danishefsky, Lawrence J. Williams

Publikováno v: Chemistry - A European Journal. 6:1366-1375

A new synthesis of the hexasaccharide MBr1 antigen (globo-H) is reported. A revised construction with improved efficiency was necessary because an anti-cancer vaccine containing this antigen is entering phase II and phase III clinical trials for pros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9da3418647a27908d37c23413daf1f71
https://doi.org/10.1002/(sici)1521-3765(20000417)6:8<1366::aid-chem1366>3.0.co

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Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: Isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens

Autor: Govindaswami Ragupathi, Lawrence J. Williams, Maria Spassova, Valery Kudryashov, William Bornmann, Susan F. Slovin, Xufang Zhang, Andrzej Zatorski, Howard I. Scher, Philip O. Livingston, Zhugang Wang, Kenneth O. Lloyd, Samuel J. Danishefsky

Publikováno v: Proceedings of the National Academy of Sciences. 97:2719-2724

We have previously reported on a carbohydrate-based vaccine program for immunotherapy in cancer patients. One such vaccine, based on the globo H antigen conjugated to the protein keyhole limpet hemocyanin (KLH), has been in clinical evaluation. Altho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f8e80ec867deb623ff95a5314c8a10
https://doi.org/10.1073/pnas.97.6.2719

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Immunization of ovarian cancer patients with a synthetic Lewisy-protein conjugate vaccine: A phase 1 trial

Autor: John Curtin, Catherine O'Flaherty, Philip O. Livingston, Andrzej Zatorski, Maria Spassova, William G. Bornmann, Govindaswami Ragupathi, Paul Sabbatini, David Spriggs, Madeline Peyton, Valery Kudryashov, Carol Aghajanian, Kenneth O. Lloyd, Samuel J. Danishefsky, Steven L. Soignet

Publikováno v: International Journal of Cancer. 87:79-85

As the initial step in developing carbohydrate-based vaccines for the treatment of ovarian cancer patients in an adjuvant setting, 25 patients were immunized with a Lewisy pentasaccharide (Ley)-keyhole limpet hemocyanin (KLH)-conjugate vaccine togeth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46f6c79ccb7b3676fffe7e7eb7ad12aa
https://doi.org/10.1002/1097-0215(20000701)87:1<79::aid-ijc12>3.0.co

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[Untitled]

Autor: Cristina Musselli, Govindaswami Ragupathi, Philip O. Livingston

Publikováno v: Journal of Clinical Immunology. 20:85-93

There is now a considerable body of information documenting the autoimmune consequences of antibodies induced by growing malignancies, or by passively administered and actively induced antibodies, in cancer patients against antigens shared by normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eed1d530c2ea84affd486344148d53d4
https://doi.org/10.1023/a:1006697728855

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Immunization of mice with fucosyl-GM1 conjugated with keyhole limpet hemocyanin results in antibodies against human small-cell lung cancer cells

Autor: Cristina Musselli, Philip O. Livingston, Govindaswami Ragupathi, Fred-Thomas Brezicka, Nancy X. Liu, Sarah Cappello

Publikováno v: Cancer Immunology, Immunotherapy. 48:483-492

Fucosyl-GM1 (Fuc-GM1) [Fucalpha1 --2Galbeta1 --3GalNAcbeta1 --4(NeuAcalpha2-3)Galbeta1 --4Glcbeta1 --O-Cer] is a small-cell-lung-cancer (SCLC)-associated ganglioside initially defined by the murine monoclonal antibody F12. On the basis of its known d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe3cabff11d2b879d0c6f750a08a368
https://doi.org/10.1007/s002620050596

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A Fully Synthetic Globo H Carbohydrate Vaccine Induces a Focused Humoral Response in Prostate Cancer Patients: A Proof of Principle

Autor: Samuel J. Danishefsky, Hyunjin M. Kim, Sucharita Adluri, Govindaswami Ragupathi, Howard I. Scher, Kenneth O. Lloyd, Susan F. Slovin, William G. Bornmann, Philip O. Livingston, Maria Spassova, Dalibor Sames, In Jong Kim

Publikováno v: Angewandte Chemie International Edition. 38:563-566

Human trials on the globo H carbohydrate vaccine (see picture, KLH=the carrier protein keyhole limpet hemocyanin) show that it produces strong IgM, and in some cases IgG, responses in patients with progressive and recurrent prostate cancer. Furthermo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0f405ecc6c9192b7085be8553a2c8d0
https://doi.org/10.1002/(sici)1521-3773(19990215)38:4<563::aid-anie563>3.0.co

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