Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Govindarajan, Thangavelu"'
Autor:
Adeolu O. Adegoke, Govindarajan Thangavelu, Ting-Fang Chou, Marcos I. Petersen, Kiyokazu Kakugawa, Julia F. May, Kevin Joannou, Qingyang Wang, Kristofor K. Ellestad, Louis Boon, Peter A. Bretscher, Hilde Cheroutre, Mitchell Kronenberg, Troy A. Baldwin, Colin C. Anderson
Publikováno v:
Open Biology, Vol 14, Iss 10 (2024)
Immunologic self-tolerance involves signals from co-inhibitory receptors. Several T cell co-inhibitors, including PD-1, are expressed upon activation, whereas CD5 and BTLA are expressed constitutively. The relationship between constitutively expresse
Externí odkaz:
https://doaj.org/article/ee80aa7d6f9748ea95d6dd974564e83b
Autor:
David P. Al-Adra, Govindarajan Thangavelu, Jiaxin Lin, William F.N. Chan, Kristofor K. Ellestad, Louis Boon, Colin C. Anderson
Publikováno v:
Cell Transplantation, Vol 31 (2022)
CD8 T cells play a key role in cancer immunotherapy and allograft rejection. However, it is not clear how they kill cells and tissues that do not have the agonist peptide-major histocompatibility complex (MHC) on their surface, as in the settings of
Externí odkaz:
https://doaj.org/article/37c63de87f2f4a79b9666d760e42fe0a
Autor:
Sara Bolivar-Wagers, Michael L. Loschi, Sujeong Jin, Govindarajan Thangavelu, Jemma H. Larson, Cameron S. McDonald-Hyman, Ethan G. Aguilar, Asim Saha, Brent H. Koehn, Mehrdad Hefazi, Mark J. Osborn, Michael C. Jensen, John E. Wagner, Christopher A. Pennell, Bruce R. Blazar
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) efficacy is complicated by graft-versus-host disease (GVHD), a leading cause of morbidity and mortality. Regulatory T cells (Tregs) have shown efficacy in preventing GVHD. However, high T
Externí odkaz:
https://doaj.org/article/13f49ac28e6643b598a93fee5b351f8a
Autor:
Govindarajan Thangavelu, Michael C. Zaiken, Fathima A. Mohamed, Ryan Flynn, Jing Du, Stephanie Y. Rhee, Megan J. Riddle, Ethan G. Aguilar, Angela Panoskaltsis-Mortari, Martin E. Sanders, Bruce R. Blazar
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Most allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients receive peripheral blood stem cell grafts resulting in a 30%–70% incidence of chronic graft-versus-host disease (cGVHD), a major cause of mortality and morbidity in long-term
Externí odkaz:
https://doaj.org/article/51fde4f6c3fd46bfa5dc1637b05aeb79
Autor:
Fathima A. Mohamed, Govindarajan Thangavelu, Stephanie Y. Rhee, Peter T. Sage, Roddy S. O’Connor, Jeffrey C. Rathmell, Bruce R. Blazar
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The therapeutic efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited by the development of graft-versus-host disease (GVHD). In GVHD, rigorous pre-conditioning regimen resets the immune landscape and inflammatory mili
Externí odkaz:
https://doaj.org/article/bfe4afcb6fa14c9e8bf1e70dbb2ca343
Autor:
Teresa L. Ramos, Sara Bolivar-Wagers, Sujeong Jin, Govindarajan Thangavelu, Federico Simonetta, Po-Yu Lin, Toshihito Hirai, Asim Saha, Brent Koehn, Leon L. Su, Lora K. Picton, Jeanette Baker, Juliane K. Lohmeyer, Megan Riddle, Cindy Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, John E. Wagner, K. Christopher Garcia, Robert S. Negrin, Bruce R. Blazar
Publikováno v:
Blood. 141:1337-1352
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative option for patients with hematological disorders and bone marrow (BM) failure syndromes. Graft-versus-host disease (GVHD) remains a leading cause of morbidity posttransplant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cb02618a16da89aba939b701c1097e
https://doi.org/10.1182/blood.2022018440
https://doi.org/10.1182/blood.2022018440
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Acute graft-vs.-host disease (GVHD) limits the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT), a main therapy to treat various hematological disorders. Despite rapid progress in understanding GVHD pathogenesis, broad immun
Externí odkaz:
https://doaj.org/article/a8961cbd18474220a4205174dffd783a
Autor:
Jemma H. Larson, Sujeong Jin, Michael Loschi, Sara Bolivar Wagers, Govindarajan Thangavelu, Michael C. Zaiken, Cameron McDonald-Hyman, Asim Saha, Ethan G. Aguilar, Brent Koehn, Mark J. Osborn, Angela Panoskaltsis-Mortari, Kelli P.A. Macdonald, Geoffrey R. Hill, William J. Murphy, Jonathan S. Serody, Ivan Maillard, Leslie S. Kean, Sangwon V. Kim, Dan R. Littman, Bruce R. Blazar
Publikováno v:
American Journal of Transplantation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81b928a597031c33223a95da375a8d70
https://doi.org/10.1016/j.ajt.2023.01.030
https://doi.org/10.1016/j.ajt.2023.01.030
Autor:
Govindarajan Thangavelu, Gabriela Andrejeva, Sara Bolivar-Wagers, Sujeong Jin, Michael C. Zaiken, Michael Loschi, Ethan G. Aguilar, Scott N. Furlan, Chrysothemis C. Brown, Yu-Chi Lee, Cameron McDonald Hyman, Colby J. Feser, Angela Panoskaltsis-Mortari, Keli L. Hippen, Kelli P. MacDonald, William J. Murphy, Ivan Maillard, Geoffrey R. Hill, David H. Munn, Robert Zeiser, Leslie S. Kean, Jeffrey C. Rathmell, Hongbo Chi, Randolph J. Noelle, Bruce R. Blazar
Publikováno v:
Cell Mol Immunol
Regulatory T cells (Tregs) promote immune homeostasis by maintaining self-tolerance and regulating inflammatory responses. Under certain inflammatory conditions, Tregs can lose their lineage stability and function. Previous studies have reported that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d110cf2e2d9fae40894c6c0e171897a6
https://doi.org/10.1038/s41423-022-00869-y
https://doi.org/10.1038/s41423-022-00869-y
Autor:
Ethan G. Aguilar, Farah Asa’ad, Kiandokht Bashiri, Rasheedunnisa Begum, Marcel W. Bekkenk, Ankit H. Bharti, Bruce R. Blazar, Siebe G. Blok, Sara Bolivar-Wagers, Emiro Buendía, Raffaele Dante Caposiena Caro, Ángela Carrasco-Sayalero, Srikumar Chakravarthi, Mingyi Chen, Enrico Crivellato, Biagio Didona, Dario Didona, Sulagna Dutta, Mitesh Dwivedi, Raquel Echavarria, Yannick S. Elshot, Luca Fania, Franklin Fuda, Israel Nieto-Gañán, Amina R. Gani, Carlos Garaicoa-Pazmiño, Lin (Jonathan) He, Keli L. Hippen, Stephen Ip, Ignacio Iturrieta-Zuazo, Shahnawaz D. Jadeja, A.M. James Shapiro, Brent H. Koehn, Ashwin Kotnis, Marija Barišić Kutija, Naresh C. Laddha, Lena Larsson, Andrew L. Mason, Tiago R. Matos, Jay Mayatra, Zesergio Melo, Marlon Múnera, Rowland Noakes, Giovanni Paolino, Nima Rezaei, Stephanie Y. Rhee, Domenico Ribatti, Claudia Geraldine Rita, Andres Sanchez, Jorge Sanchez, Pallav Sengupta, Consolato M. Sergi, Atsushi Tanaka, Govindarajan Thangavelu, Jayvadan Vaishnav, Citlalin Vega-Roman, Kevin Verhoeff, Niloufar Yazdanpanah
Publikováno v:
Translational Autoimmunity ISBN: 9780323853897
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e2b31772422246c2219da21ec398221
https://doi.org/10.1016/b978-0-323-85389-7.09987-7
https://doi.org/10.1016/b978-0-323-85389-7.09987-7
