Výsledky vyhledávání

Akademický článek

Genome-wide siRNA screens identify RBBP9 function as a potential target in Fanconi anaemia-deficient head-and-neck squamous cell carcinoma

Autor: Govind Pai, Khashayar Roohollahi, Davy Rockx, Yvonne de Jong, Chantal Stoepker, Charlotte Pennings, Martin Rooimans, Lianne Vriend, Sander Piersma, Connie R. Jimenez, Renee X. De Menezes, Victor W. Van Beusechem, Ruud H. Brakenhoff, Hein Te Riele, Rob M. F. Wolthuis, Josephine C. Dorsman

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)

A genome-wide siRNA screen on patient-derived Fanconi anemia pathway-deficient head-and-neck squamous-cell-carcinoma (HNSCC) cell lines identifies RBBP9 as a candidate therapeutic target.

Externí odkaz: https://doaj.org/article/d4abaadf82fc4ce89a966aaa06a906bf

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

BIRC2–BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia

Autor: Khashayar Roohollahi, Yvonne de Jong, Govind Pai, Mohamad Amr Zaini, Klaas de Lint, Daoud Sie, Martin A. Rooimans, Davy Rockx, Elizabeth E. Hoskins, Najim Ameziane, Rob Wolthuis, Hans Joenje, Susanne I. Wells, Josephine Dorsman

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)

Abstract Head-and-neck squamous cell carcinomas (HNSCCs) are relatively common in patients with Fanconi anemia (FA), a hereditary chromosomal instability disorder. Standard chemo-radiation therapy is not tolerated in FA due to an overall somatic hype

Externí odkaz: https://doaj.org/article/110c2faaaa8b4ac3b56440406ab278bf

Zobrazit plný text záznamu

Plný text ve formátu HTML

BIRC2–BIRC3 amplification

Publikováno v: Roohollahi, K, de Jong, Y, Pai, G, Zaini, M A, de Lint, K, Sie, D, Rooimans, M A, Rockx, D, Hoskins, E E, Ameziane, N, Wolthuis, R, Joenje, H, Wells, S I & Dorsman, J 2022, ' BIRC2–BIRC3 amplification : a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia ', Scientific Reports, vol. 12, no. 1, 45 . https://doi.org/10.1038/s41598-021-04042-9
Scientific Reports
Scientific Reports, 12(1):45. Nature Publishing Group
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)

Head-and-neck squamous cell carcinomas (HNSCCs) are relatively common in patients with Fanconi anemia (FA), a hereditary chromosomal instability disorder. Standard chemo-radiation therapy is not tolerated in FA due to an overall somatic hypersensitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1246697a12884d6a7133efb205958e6
http://www.scopus.com/inward/record.url?scp=85122438265&partnerID=8YFLogxK

Zobrazit plný text záznamu

Plný text ve formátu HTML

Case 4: A Preterm Infant with a Necrotic Ulcer Over the Perianal Area

Autor: Mubark Al Yaqoobi, Amal Al Jabri, Govind Pai, Mohmmed Al Yahmadi, Manoj Malviya, Satish Bhandari

Publikováno v: NeoReviews. 18:e448-e452

A 1.07-kg male infant with severe growth restriction is born at 30 weeks’ gestational age to a 36-year-old gravida 3, para 2 mother by emergency cesarean delivery for nonreassuring heart tracing. The parents are of low socioeconomic status and are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b87ac51a458c14d9c4edceaa148b806
https://doi.org/10.1542/neo.18-7-e448

Zobrazit plný text záznamu

Sulphonation of dehydroepiandrosterone and neurosteroids: molecular cloning, expression, and functional characterization of a novel zebrafish SULT2 cytosolic sulphotransferase

Autor: T. Govind Pai, Chau-Ching Liu, Takuya Sugahara, Ming-Cheh Liu, Yuh-Shyong Yang

Publikováno v: Biochemical Journal. 375:785-791

By searching the zebrafish EST (expressed-sequence tag) database, we have identified two partial cDNA clones encoding the 5' and 3' regions of a putative zebrafish sulphotransferase (ST). Using the reverse transcription-PCR technique, a full-length c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d226efeefcf467f5e2d9a1a7fbe4d9
https://doi.org/10.1042/bj20031050

Zobrazit plný text záznamu

Sulfation of hydroxychlorobiphenyls. Molecular cloning, expression, and functional characterization of zebrafish SULT1 sulfotransferases

Autor: Ming-Cheh Liu, Chau-Ching Liu, Masahito Suiko, Yoichi Sakakibara, T. Govind Pai, Paul Collodi, Takuya Sugahara, Kazuo Nishiyama

Publikováno v: European Journal of Biochemistry. 270:2404-2411

As a first step toward developing a zebrafish model for investigating the role of sulfation in counteracting environmental estrogenic chemicals, we have embarked on the identification and characterization of cytosolic sulfotransferases (STs) in zebra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bb86428d5d1df5e4a21997e5a1e985
https://doi.org/10.1046/j.1432-1033.2003.03608.x

Zobrazit plný text záznamu

Molecular cloning, expression, and functional characterization of a novel zebrafish cytosolic sulfotransferase

Autor: Ming-Cheh Liu, Takuya Sugahara, Chau Ching Liu, T. Govind Pai

Publikováno v: Biochemical and Biophysical Research Communications. 300:725-730

By searching the zebrafish expressed sequence tag (EST) database, we have identified a cDNA clone encoding a putative zebrafish cytosolic sulfotransferase (ST). This cDNA was isolated and subjected to nucleotide sequencing. Analysis of the sequence d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac4ce383a0ff4ba95e4e4c424191a98
https://doi.org/10.1016/s0006-291x(02)02915-7

Zobrazit plný text záznamu

Manganese Stimulation and Stereospecificity of the Dopa (3,4-Dihydroxyphenylalanine)/Tyrosine-sulfating Activity of Human Monoamine-form Phenol Sulfotransferase

Autor: Masahito Suiko, Ming-Cheh Liu, Yoichi Sakakibara, Kei Ohkimoto, Takuya Sugahara, T. Govind Pai

Publikováno v: Journal of Biological Chemistry. 277:43813-43820

Kinetic studies were performed to dissect the mechanism underlying the remarkable Mn(2+) stimulation of the Dopa/tyrosine-sulfating activity of the human monoamine (M)-form phenol sulfotransferase (PST). The activities and the stimulation by Mn(2+) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2b3a1e8e09ab8f4f7c10463424d4053
https://doi.org/10.1074/jbc.m200785200

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání