Výsledky vyhledávání - "Goverdhan Lanka"

Akademický článek

Identification of potential antiviral lead inhibitors against SARS-CoV-2 main protease: Structure-guided virtual screening, docking, ADME, and MD Simulation based approach

Autor: Goverdhan Lanka, Revanth Bathula, Balaram Ghosh, Sarita Rajender Potlapally

Publikováno v: Artificial Intelligence Chemistry, Vol 1, Iss 2, Pp 100015- (2023)

The novel coronavirus disease (COVID-19) was caused by a new strain of the virus SARS-CoV-2 in December 2019 emerged as deadly pandemic that affected millions of people worldwide. Factors such as lack of effective drugs, vaccine resistance, gene muta

Externí odkaz: https://doaj.org/article/8b47f4671a7b4438bc45a506e6809525

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Fragment-based investigation of thiourea derivatives as VEGFR-2 inhibitors: a cross-validated approach of ligand-based and structure-based molecular modeling studies

Autor: Suvankar Banerjee, Shristi Kejriwal, Balaram Ghosh, Goverdhan Lanka, Tarun Jha, Nilanjan Adhikari

Angiogenesis is mediated by the vascular endothelial growth factor (VEGF) that plays a key role in the modulation of progression, invasion and metastasis, related to solid tumors and hematological malignancies. Several small-molecule VEGFR-2 inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a86c45d0d070f2186053fe4c18e07d

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Homology modelling and virtual screening to explore potent inhibitors for MAP2K3 protein

Autor: Goverdhan Lanka, Alok Jain, Sarita Rajender Potlapally, Gururaj Somadi, Nazmina Vhora, Sivan Sree Kanth, Manan Bhargavi

Publikováno v: Structural Chemistry. 32:1039-1051

MAP2K3 protein is mitogen-activated protein kinase belonging to the family of kinases involved in intracellular cell proliferation. The mammalian MAPK family that consists of ERK, p38 and JNK signalling pathway is showing a critical role in the regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::425f0c39e998c4af1488536bd3189ce2
https://doi.org/10.1007/s11224-020-01667-w

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Structural Insight into PRMT5 Inhibitors through Amalgamating Pharmacophore-Based Virtual Screening, ADME-Toxicity and Binding Energy Studies and Identify New Inhibitors by Molecular Docking

Autor: Goverdhan Lanka, Revanth Bathula, Narasimha Muddagoni, Sarita Rajender Potlapally, Gururaj Somadi, Sree Kanth Sivan

Protein arginine methyltransferase 5 (PRMT5) is a member of the methyltransferases family, a type II arginine enzyme that is crucial for many cellular processes and is associated with many cancer diseases. In this study, pharmacophore-based 3D QSAR m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::052eb221e02edeeaf53e3beee858c79e
https://doi.org/10.21203/rs.3.rs-819089/v1

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Structure-based identification of potential novel inhibitors targeting FAM3B (PANDER) causing type 2 diabetes mellitus through virtual screening

Autor: Sravanthi Nakkala, Goverdhan Lanka, Manan Bhargavi, Mahendar Dasari, Revanth Bathula, Gururaj Somadi, Sarita Rajender Potlapally

Publikováno v: Journal of Receptors and Signal Transduction. 39:253-263

Type 2 diabetes mellitus is a metabolic disorder that requires potent therapeutic approaches. The FAM3B is a cytokine-like protein also referred to as PANcreatic-DERrived factor (PANDER) which mainly exists in pancreatic islets. In the process of ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42615c760c73799ea71afbebb8f60f9c
https://doi.org/10.1080/10799893.2019.1660897

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Identification of potential Aurora kinase-C protein inhibitors: an amalgamation of energy minimization, virtual screening, prime MMGBSA and AutoDock

Autor: Sree Kanth Sivan, Revanth Bathula, Manan Bhargavi, Goverdhan Lanka, Mahendar Dasari, Narasimha Muddagoni, Sarita Rajender Potlapally, Gururaj Somadi, Sravanthi Nakkala

Publikováno v: Journal of biomolecular structuredynamics. 38(8)

Genomic instability is a trademark of cancer evolution, there is still a wide necessity to discover safe and effective anti-cancer drugs. Aurora kinase-C protein is a member of the Aurora kinase family involved in regulating mitosis phases of the cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d34ad86e223b72e61b44f1a07d015f4
https://pubmed.ncbi.nlm.nih.gov/31204611

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Identification and optimisation of novel selective inhibitors against human regulator of G protein signalling 2 (RGS2) protein for type 2 diabetes mellitus: an in silico approach

Autor: Goverdhan Lanka, Mahendar Dasari, Sarita Rajender Potlapally, Revanth Bathula, Manan Bhargavi

Publikováno v: International Journal of Computational Biology and Drug Design. 14:166

Regulator of G protein signalling 2 (RGS2) protein negatively modulates GPCR signalling pathway causing type 2 diabetes and treated as drug target for the new lead identification. Since RGS2 lacks its experimental structure, the 3D structure of RGS2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bd211f4ec5b9fdfa39dbf438b19863
https://doi.org/10.1504/ijcbdd.2021.117183

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