335 Cryogenic electron microscopy studies of human CFTR folding and conformational dynamics elucidate a novel potentiator binding site in the nucleotide binding domains that supports an alternative channelgating mechanism

Autor: Wang, C., Yang, Z., Aleksandrov, A., Vorobiev, S., Loughlin, B., Rich, Z., Clarke, O., Jiang, F., Brouillette, C., Urbatsch, I., Frank, J., Lukacs, G., Govaerts, C., Kappes, J., Hunt, J.

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Hyphenation of liquid chromatography to ion trap mass spectrometry to identify minor components in polypeptide antibiotics.

Autor: Govaerts, C.¹, Adams, E.¹, Van Schepdael, Ann¹ ann.vanschepdael@pharm.kuleuven.ac.be, Hoogmartens, J.¹

Publikováno v: Analytical & Bioanalytical Chemistry. Nov2003, Vol. 377 Issue 5, p909-921. 13p.

An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity.

Autor: Debruycker V; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium., Hutchin A; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium., Masureel M; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium.; Department of Structural Biology, Genentech, Inc., South San Francisco, CA, USA., Ficici E; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Martens C; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium., Legrand P; Synchrotron SOLEIL, L'Orme des Merisiers, Saint-Aubin 91192, Gif sur Yvette, France., Stein RA; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA., Mchaourab HS; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA., Faraldo-Gómez JD; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Remaut H; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.; Structural and Molecular Microbiology, VIB-VUB Center for Structural Biology, Brussels, Belgium., Govaerts C; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium. cgovaert@ulb.ac.be.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Sep; Vol. 27 (9), pp. 829-835. Date of Electronic Publication: 2020 Jul 27.

A topological switch in CFTR modulates channel activity and sensitivity to unfolding.

Autor: Scholl D; SFMB, Université Libre de Bruxelles, Brussels, Belgium., Sigoillot M; SFMB, Université Libre de Bruxelles, Brussels, Belgium., Overtus M; SFMB, Université Libre de Bruxelles, Brussels, Belgium., Martinez RC; SFMB, Université Libre de Bruxelles, Brussels, Belgium., Martens C; SFMB, Université Libre de Bruxelles, Brussels, Belgium., Wang Y; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK., Pardon E; VIB-VUB center for Structural Biology, VIB, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium., Laeremans T; VIB-VUB center for Structural Biology, VIB, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium., Garcia-Pino A; Cellular and Molecular Microbiology, Université Libre de Bruxelles, Gosselies, Belgium., Steyaert J; VIB-VUB center for Structural Biology, VIB, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium., Sheppard DN; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK., Hendrix J; Dynamic Bioimaging Lab, Advanced Optical Microscopy Centre and Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.; Molecular Imaging and Photonics, Chemistry Department, KU Leuven, Leuven, Belgium., Govaerts C; SFMB, Université Libre de Bruxelles, Brussels, Belgium. Cedric.Govaerts@ulb.ac.be.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2021 Sep; Vol. 17 (9), pp. 989-997. Date of Electronic Publication: 2021 Aug 02.

First Report of Polymorphisms and Genetic Characteristics of Prion-like Protein Gene (PRND) in Cats.

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