Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats

Autor: Janiak, P. ^*, Poirier, B., Bidouard, J.-P., Cadrouvele, C., Pierre, F., Gouraud, L., Barbosa, I., Dedio, J., Maffrand, J.-P., Le Fur, G., O'Connor, S., Herbert, J.-M.

Publikováno v: In Kidney International 1 December 2007 72(11):1345-1357

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New insights into the pathological role of TNF-α in early cardiac dysfunction and subsequent heart failure after infarction in rats.

Autor: Berthonneche, C., Sulpice, T., Boucher, F., Gouraud, L., de Leiris, J., O'Connor, S.E., Herbert, J.-M., Janiak, P.

Publikováno v: American Journal of Physiology: Heart & Circulatory Physiology; Jul2004, Vol. 287 Issue 1, pH340-H350, 11p, 4 Color Photographs, 5 Charts, 5 Graphs

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A G protein-biased S1P 1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers.

Autor: Poirier B; Diabetes and Cardiovascular Research, Sanofi R&D, 1 Avenue Pierre Brossolette, 91385 Chilly Mazarin, France., Briand V; Diabetes and Cardiovascular Research, Sanofi R&D, 1 Avenue Pierre Brossolette, 91385 Chilly Mazarin, France., Kadereit D; Medicinal Chemistry, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, 65926 Frankfurt am Main,, Germany., Schäfer M; Diabetes and Cardiovascular Research, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, 65926 Frankfurt am Main, Germany., Wohlfart P; Diabetes and Cardiovascular Research, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, 65926 Frankfurt am Main, Germany., Philippo MC; Diabetes and Cardiovascular Research, Sanofi R&D, 1 Avenue Pierre Brossolette, 91385 Chilly Mazarin, France., Caillaud D; Diabetes and Cardiovascular Research, Sanofi R&D, 1 Avenue Pierre Brossolette, 91385 Chilly Mazarin, France., Gouraud L; Diabetes and Cardiovascular Research, Sanofi R&D, 1 Avenue Pierre Brossolette, 91385 Chilly Mazarin, France., Grailhe P; Diabetes and Cardiovascular Research, Sanofi R&D, 1 Avenue Pierre Brossolette, 91385 Chilly Mazarin, France., Bidouard JP; Diabetes and Cardiovascular Research, Sanofi R&D, 1 Avenue Pierre Brossolette, 91385 Chilly Mazarin, France., Trellu M; Drug Metabolism and Pharmacokinetics, Sanofi R&D, 1 Avenue Pierre Brossolette, 91385 Chilly-Mazarin, France., Muslin AJ; Diabetes and Cardiovascular Research, Sanofi US Services, 640 Memorial Drive, Cambridge, MA 02139, USA., Janiak P; Diabetes and Cardiovascular Research, Sanofi R&D, 1 Avenue Pierre Brossolette, 91385 Chilly Mazarin, France., Parkar AA; Diabetes and Cardiovascular Research, Sanofi US Services, 55 Corporate Drive, Bridgewater, NJ 08807, USA. ashfaqaparkar@gmail.com.

Publikováno v: Science signaling [Sci Signal] 2020 Jun 02; Vol. 13 (634). Date of Electronic Publication: 2020 Jun 02.