Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gouranga P. Jana"'
Autor:
Stanley C. Xie, Yinuo Wang, Craig J. Morton, Riley D. Metcalfe, Con Dogovski, Charisse Flerida A. Pasaje, Elyse Dunn, Madeline R. Luth, Krittikorn Kumpornsin, Eva S. Istvan, Joon Sung Park, Kate J. Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N. Bhebhe, Dana M. Klug, Peter J. Rutledge, Luiz C. Godoy, Sumanta Dey, Mariana Laureano De Souza, Jair L. Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerry Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas Williamson, Gouranga P. Jana, Bikash C. Maity, Patrick Thomson, Thomas Foley, Derek S. Tan, Jacquin C. Niles, Byung Woo Han, Daniel E. Goldberg, Jeremy Burrows, David A. Fidock, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael D. W. Griffin, Matthew H. Todd, Leann Tilley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a ne
Externí odkaz:
https://doaj.org/article/74ceb3d2587846d1a75544faccf7d8f1
Autor:
Krittikorn Kümpornsin, Theerarat Kochakarn, Tomas Yeo, John Okombo, Madeline R. Luth, Johanna Hoshizaki, Mukul Rawat, Richard D. Pearson, Kyra A. Schindler, Sachel Mok, Heekuk Park, Anne-Catrin Uhlemann, Gouranga P. Jana, Bikash C. Maity, Benoît Laleu, Elodie Chenu, James Duffy, Sonia Moliner Cubel, Virginia Franco, Maria G. Gomez-Lorenzo, Francisco Javier Gamo, Elizabeth A. Winzeler, David A. Fidock, Thanat Chookajorn, Marcus C. S. Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract In vitro evolution of drug resistance is a powerful approach for identifying antimalarial targets, however, key obstacles to eliciting resistance are the parasite inoculum size and mutation rate. Here we sought to increase parasite genetic d
Externí odkaz:
https://doaj.org/article/cd0bb7acaa454eeba503bf34e9f1ecc8
Autor:
Benoît Laleu, Kelly Rubiano, Tomas Yeo, Irene Hallyburton, Mark Anderson, Benigno Crespo‐Fernandez, Francisco‐Javier Gamo, Yevgeniya Antonova‐Koch, Pamela Orjuela‐Sanchez, Sergio Wittlin, Gouranga P. Jana, Bikash C. Maity, Elodie Chenu, James Duffy, Peter Sjö, David Waterson, Elizabeth Winzeler, Eric Guantai, David A. Fidock, Thomas G. Hansson
Publikováno v:
ChemMedChem. 17
New antimalarial treatments with novel mechanism of action are needed to tackle Plasmodium falciparum infections that are resistant to first-line therapeutics. Here we report the exploration of MMV692140 (2) from the Pathogen Box, a collection of 400
Publikováno v:
Synthesis. 2010:3179-3187
A one-pot multicomponent synthesis of phenanthridine and acridine derivatives is described. This method includes the in situ generation of furo[3,4-c]isoquinoline and furo[3,4-b]quinoline intermediates by the coupling of heteroaromatic o-alkynyl carb
Publikováno v:
Journal of Organometallic Chemistry. 694:4100-4106
The reaction of Fischer carbene complex with o -alkynylpyridine carbonyl derivatives has been investigated. This involves the generation of furo[3,4- c ]pyridine as transient intermediates through the coupling of o -alkynylpyridine carbonyl derivativ
Autor:
Gouranga P. Jana, Binay K. Ghorai
Publikováno v:
Tetrahedron. 63:12015-12025
The coupling of Fischer carbene complexes with 2-alkynyl-3-pyridine carbonyl derivatives has been examined. The reaction affords furo[3,4-b]pyridine as transient intermediates; the latter undergo [4+2] cycloaddition with an electron-deficient dienoph
Autor:
Gouranga P. Jana, Binary K. Ghorai
Publikováno v:
ChemInform. 40
Autor:
Gouranga P. Jana, Binay K. Ghorai
Publikováno v:
ChemInform. 39
The coupling of Fischer carbene complexes with 2-alkynyl-3-pyridine carbonyl derivatives has been examined. The reaction affords furo[3,4-b]pyridine as transient intermediates; the latter undergo [4+2] cycloaddition with an electron-deficient dienoph