Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Goun Je"'
Autor:
Subhrangshu Guhathakurta, Min Kyung Song, Sambuddha Basu, Goun Je, Ana Clara Cristovao, Yoon-Seong Kim
Publikováno v:
International Neurourology Journal, Vol 26, Iss Suppl 2, Pp S85-93 (2022)
Purpose Deregulation of SNCA encoding α-synuclein (α-SYN) has been associated with both the familial and sporadic forms of Parkinson disease (PD). Epigenetic regulation plays a crucial role in PD. The intron1 of SNCA harbors a large unmethylated Cp
Externí odkaz:
https://doaj.org/article/0225a80f142c47588ce19f55e3511d6e
Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease
Autor:
Subhrangshu Guhathakurta, Jinil Kim, Levi Adams, Sambuddha Basu, Min Kyung Song, Evan Adler, Goun Je, Mariana Bernardo Fiadeiro, Yoon‐Seong Kim
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-16 (2021)
Abstract Epigenetic deregulation of α‐synuclein plays a key role in Parkinson’s disease (PD). Analysis of the SNCA promoter using the ENCODE database revealed the presence of important histone post‐translational modifications (PTMs) including
Externí odkaz:
https://doaj.org/article/1e91599b8ad14629b094c77d6a7c5a3b
Publikováno v:
Cells, Vol 11, Iss 13, p 2066 (2022)
Since the discovery of Cu/Zn superoxide dismutase (SOD1) gene mutation, in 1993, as the first genetic abnormality in amyotrophic lateral sclerosis (ALS), over 50 genes have been identified as either cause or modifier in ALS and ALS/frontotemporal dem
Externí odkaz:
https://doaj.org/article/d958982a2d064c3a83b3763fabad4b95
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-9 (2018)
Abstract Alpha-synuclein (α-SYN) is one of the key contributors in Parkinson’s disease (PD) pathogenesis. Despite the fact that increased α-SYN levels are considered one of the key contributors in developing PD, the molecular mechanisms underlyin
Externí odkaz:
https://doaj.org/article/45e556dc25b14adabe55777859e66419
Publikováno v:
Acta Neurol Scand
Background Infarction of the medulla has been associated with prolongation of the QTc, severe arrhythmia, and sudden cardiac death, yet the precise anatomical substrate remains uncertain. Aims We sought to determine the possible anatomical structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554737b5390a87d71c27e556994aee4c
https://doi.org/10.1111/ane.13445
https://doi.org/10.1111/ane.13445
Publikováno v:
Neurological Research. 43:616-632
Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of upper and lower motor neurons with high burden on society. Despite tremendous efforts over the last sev...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f03ce260d4149adf383221c90a4fd7e
https://doi.org/10.1080/01616412.2021.1893564
https://doi.org/10.1080/01616412.2021.1893564
Autor:
Mehdi Ghasemi, Goun Je
Publikováno v:
World Journal of Obstetrics and Gynecology. 9:1-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19907fff632a647fbe05c32c6302464b
https://doi.org/10.5317/wjog.v9.i1.1
https://doi.org/10.5317/wjog.v9.i1.1
Autor:
M. Flint Beal, Kyung Sik Yoon, Marta Esteves, António J. Salgado, João A. Queiroz, Lichuan Yang, Subhrangshu Guhathakurta, Ana C. Cristóvão, Yoon Seong Kim, Filipa Lopes Campos, Beatriz M. Fonseca, Nuno Sousa, Goun Je, Liliana Bernardino, Gilberto Alves
Publikováno v:
European Journal of Neuroscience. 52:3242-3255
Animal models of human diseases are crucial experimental tools to investigate the mechanisms involved in disease pathogenesis and to develop new therapies. In spite of the numerous animal models currently available that reproduce several neuropatholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d8551e9f24267db62eef589c245127
https://doi.org/10.1111/ejn.14683
https://doi.org/10.1111/ejn.14683
Autor:
Guhathakurta, Subhrangshu, Min Kyung Song, Basu, Sambuddha, Goun Je, Cristovao, Ana Clara, Yoon-Seong Kim
Publikováno v:
International Neurourology Journal; 2022 Supplement, Vol. 26, pS85-S93, 15p
Publikováno v:
Stroke. 52
Objective: To determine the spatial relationship between acute medullary infarction and QTc prolongation. Background: Ischemic stroke has been associated with QTc-prolongation which increases the risk of cardiac arrhythmia and sudden cardiac death. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7632abcd1772a112ea7e4c52c3ff02ef
https://doi.org/10.1161/str.52.suppl_1.p130
https://doi.org/10.1161/str.52.suppl_1.p130