P96 Preliminary results on the study to identify the relation between midazolam concentrations and level of sedation in critically mechanically ventilated children

Autor: Upadhyay, PJ, Vet, NJ, Goulooze, SC, Krekels, EHJ, de Wildt, SN, Knibbe, CAJ

Publikováno v: Archives of Disease in Childhood; 2019, Vol. 104 Issue: 6 pe57-e57, 1p

Integrated Population Pharmacokinetics of Daprodustat in Patients with Chronic Kidney Disease with Anemia.

Autor: Mahar KM; GSK, Collegeville, PA, USA. kelly.m.mahar@gsk.com., Yang S; GSK, London, UK., Mesic E; Leiden Experts on Advanced Pharmacokinetics and Pharmacodynamics (LAP&P), Leiden, The Netherlands., Post TM; Leiden Experts on Advanced Pharmacokinetics and Pharmacodynamics (LAP&P), Leiden, The Netherlands., Goulooze SC; Leiden Experts on Advanced Pharmacokinetics and Pharmacodynamics (LAP&P), Leiden, The Netherlands.

Publikováno v: Clinical pharmacokinetics [Clin Pharmacokinet] 2024 Sep; Vol. 63 (9), pp. 1327-1341. Date of Electronic Publication: 2024 Sep 11.

When will the Glomerular Filtration Rate in Former Preterm Neonates Catch up with Their Term Peers?

Autor: Wu Y; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, 2333CC, Leiden, The Netherlands., Allegaert K; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Development and Regeneration, and Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium., Flint RB; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Goulooze SC; Leiden Experts On Advanced Pharmacokinetics and Pharmacodynamics (LAP&P), Leiden, The Netherlands., Välitalo PAJ; School of Pharmacy, University of Eastern Finland, Yliopistonranta 1 C, 70210, Kuopio, Finland.; Finnish Medicines Agency, Hallituskatu 12-14, 70100, Kuopio, Finland., de Hoog M; Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Mulla H; Department of Pharmacy, University Hospitals of Leicester, Glenfield Hospital, Leicester, LE39QP, England., Sherwin CMT; Department of Pediatrics, Wright State University Boonshoft School of Medicine/Dayton Children's Hospital, One Children's Plaza, Dayton, OH, USA., Simons SHP; Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Krekels EHJ; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, 2333CC, Leiden, The Netherlands.; Certara Inc, Princeton, NJ, USA., Knibbe CAJ; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, 2333CC, Leiden, The Netherlands.; Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.; Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands., Völler S; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, 2333CC, Leiden, The Netherlands. s.voller@lacdr.leidenuniv.nl.; Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands. s.voller@lacdr.leidenuniv.nl.

Publikováno v: Pharmaceutical research [Pharm Res] 2024 Apr; Vol. 41 (4), pp. 637-649. Date of Electronic Publication: 2024 Mar 12.

Advances in pharmacokinetic-pharmacodynamic modelling for pediatric drug development: extrapolations and exposure-response analyses.

Autor: Goulooze SC; LAP&P Consultants BV, Leiden, The Netherlands., Vis PW; LAP&P Consultants BV, Leiden, The Netherlands., Krekels EHJ; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Knibbe CAJ; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.; Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands.

Publikováno v: Expert review of clinical pharmacology [Expert Rev Clin Pharmacol] 2023 Jul-Dec; Vol. 16 (12), pp. 1201-1209. Date of Electronic Publication: 2023 Dec 09.

Dose-Exposure-Response Analysis of the Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone on UACR and eGFR: An Analysis from FIDELIO-DKD.

Autor: Goulooze SC; Leiden Experts on Advanced Pharmacokinetics and Pharmacodynamics (LAP&P), Leiden, The Netherlands., Heerspink HJL; Department Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van Noort M; Leiden Experts on Advanced Pharmacokinetics and Pharmacodynamics (LAP&P), Leiden, The Netherlands., Snelder N; Leiden Experts on Advanced Pharmacokinetics and Pharmacodynamics (LAP&P), Leiden, The Netherlands., Brinker M; Bayer AG, Pharmaceuticals R&D, Clinical Development, Leverkusen, Germany., Lippert J; Bayer AG, Pharmaceuticals R&D, Pharmacometrics, Building B106, Room 205, 51368, Leverkusen, Germany., Eissing T; Bayer AG, Pharmaceuticals R&D, Pharmacometrics, Building B106, Room 205, 51368, Leverkusen, Germany. thomas.eissing@bayer.com.

Publikováno v: Clinical pharmacokinetics [Clin Pharmacokinet] 2022 Jul; Vol. 61 (7), pp. 1013-1025. Date of Electronic Publication: 2022 May 05.