Zobrazeno 1 - 10
of 491
pro vyhledávání: '"Gou Young Koh"'
Autor:
Ryeonghwa Kang, Kyungdeok Kim, Yewon Jung, Sang-Han Choi, Chanhee Lee, Geun Ho Im, Miram Shin, Kwangmin Ryu, Subin Choi, Esther Yang, Wangyong Shin, Seungjoon Lee, Suho Lee, Zachary Papadopoulos, Ji Hoon Ahn, Gou Young Koh, Jonathan Kipnis, Hyojin Kang, Hyun Kim, Won-Ki Cho, Soochul Park, Seong-Gi Kim, Eunjoon Kim
Publikováno v:
PLoS Biology, Vol 22, Iss 5, p e3002596 (2024)
Autism spectrum disorders (ASD) frequently accompany macrocephaly, which often involves hydrocephalic enlargement of brain ventricles. Katnal2 is a microtubule-regulatory protein strongly linked to ASD, but it remains unclear whether Katnal2 knockout
Externí odkaz:
https://doaj.org/article/5c97fd7bf8714d0980f93431d5b5bc26
Autor:
Hyuek Jong Lee, Jueun Lee, Myung Jin Yang, Young-Chan Kim, Seon Pyo Hong, Jung Mo Kim, Geum-Sook Hwang, Gou Young Koh
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Active thermogenesis in the brown adipose tissue (BAT) facilitating the utilization of lipids and glucose is critical for maintaining body temperature and reducing metabolic diseases, whereas inactive BAT accumulates lipids in brown adipocyt
Externí odkaz:
https://doaj.org/article/6a7b56122764406f9ab2bf5c8e68b113
Autor:
Gyunghee Jo, Jeomil Bae, Ho Jeong Hong, Ah-reum Han, Do-Kyun Kim, Seon Pyo Hong, Jung A Kim, Sangkyu Lee, Gou Young Koh, Ho Min Kim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Angiopoietin (Angpt)-Tie receptor 2 (Tie2) regulates vascular stability and is thus a potential therapeutic target in vascular diseases. Here, the authors report a Tie2-agonistic antibody which targets a site distinct from the Angpt 1-binding site an
Externí odkaz:
https://doaj.org/article/fc69bcd280cf4fe0bfa69e52efbb0a96
Autor:
Myeon-Sik Yang, Byung Kwan Oh, Daram Yang, Eun Young Oh, Yeonhwa Kim, Kyung Won Kang, Chae Woong Lim, Gou Young Koh, Sang-Myeong Lee, Bumseok Kim
Publikováno v:
Veterinary Research, Vol 52, Iss 1, Pp 1-19 (2021)
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic is causing a global crisis. It is still unresolved. Although many therapies and vaccines are being studied, they are still in their infancy. As this pandemic conti
Externí odkaz:
https://doaj.org/article/78e74fdd31d5431f8996b5d7ecb1a93c
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
How STING agonists exert anti-tumour effects remains unclear. Here, the authors show that STING agonists suppress tumor growth of subcutaneous xenografts models inducing early apoptosis of endothelial cells through the TNFalpha-TNFR1 signaling, while
Externí odkaz:
https://doaj.org/article/f5d68f62866e4af6b7511fa91654946e
Autor:
Young-Geun Choe, Jin-Hui Yoon, Jongyoon Joo, Bokyung Kim, Seon Pyo Hong, Gou Young Koh, Dong-Seok Lee, Wang-Yuhl Oh, Yong Jeong
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The neurovascular unit is a functional unit composed of neurons, glial cells, pericytes, and endothelial cells which sustain brain activity. While pericyte is a key component of the neurovascular unit, its role in cerebral blood flow regulation remai
Externí odkaz:
https://doaj.org/article/493a459ad79643a7a4dbda0ffc36bfae
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-20 (2020)
Abstract Cerebral amyloid angiopathy (CAA), defined as the accumulation of amyloid-beta (Aβ) on the vascular wall, is a major pathology of Alzheimer’s disease (AD) and has been thought to be caused by the failure of Aβ clearance. Although two typ
Externí odkaz:
https://doaj.org/article/b76a2bcdda7541aeb7b4f06cb99e9410
Autor:
Seon Pyo Hong, Myung Jin Yang, Hyunsoo Cho, Intae Park, Hosung Bae, Kibaek Choe, Sang Heon Suh, Ralf H. Adams, Kari Alitalo, Daesik Lim, Gou Young Koh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Intestinal stromal cells (IntSCs) play essential roles in maintaining intestinal homeostasis. Here the authors show that VEGF-C expression in specialized IntSCs is regulated by YAP/TAZ, and VEGF-C is responsible for maintaining lacteal integrity, thu
Externí odkaz:
https://doaj.org/article/a5ba88c8e1874761a4ed5a9319bf3ec3
Autor:
Bong Ihn Koh, Hyuek Jong Lee, Pil Ae Kwak, Myung Jin Yang, Ju-Hee Kim, Hyung-Seok Kim, Gou Young Koh, Injune Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Severe head injury results in critical damage of blood vessels of the meninges and brain parenchyma. Here, the authors describe key pathways governing meningeal vascular regeneration following head injury, characterizing the differential roles of VEG
Externí odkaz:
https://doaj.org/article/2eb4ae02c0ec45c493c733e63d569b0b
Autor:
Hosung Bae, Ki Yong Hong, Choong-kun Lee, Cholsoon Jang, Seung-Jun Lee, Kibaek Choe, Stefan Offermanns, Yulong He, Hyuek Jong Lee, Gou Young Koh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Fat uptake and storage in subcutaneous adipose tissue (SAT) prevents ectopic fat accumulation and associated metabolic complications, however, the underlying mechanisms are incompletely understood. Here, the authors show that adipose angiopoietin-2 (
Externí odkaz:
https://doaj.org/article/fd246ddc209c49668f2467366b4c24ec