Zobrazeno 1 - 10 of 1 587 pro vyhledávání: '"Gottschling D"'
1
Akademický článek
Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability.
Autor: Heine N; Boehringer Ingelheim Pharma GmbH & Co. KG, Global Medicinal Chemistry, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany., Weber A; Boehringer Ingelheim Pharma GmbH & Co. KG, Global Medicinal Chemistry, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany., Pautsch A; Boehringer Ingelheim Pharma GmbH & Co. KG, Global Medicinal Chemistry, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany., Gottschling D; Boehringer Ingelheim Pharma GmbH & Co. KG, Global Medicinal Chemistry, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany., Uphues I; Boehringer Ingelheim Pharma GmbH & Co. KG, Cardiometabolic Diseases Research, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany., Bauer M; Boehringer Ingelheim Pharma GmbH & Co. KG, Global Medicinal Chemistry, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany., Ebenhoch R; Boehringer Ingelheim Pharma GmbH & Co. KG, Global Medicinal Chemistry, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany., Magarkar A; Boehringer Ingelheim Pharma GmbH & Co. KG, Global Medicinal Chemistry, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany., Nosse B; Boehringer Ingelheim Pharma GmbH & Co. KG, Global Medicinal Chemistry, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany; Boehringer Ingelheim International GmbH, Business Development & Licensing, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany., Kley JT; Boehringer Ingelheim Pharma GmbH & Co. KG, Global Medicinal Chemistry, Birkendorfer Straße 65, 88397 Biberach an der Riß, Germany. Electronic address: joerg.kley@boehringer-ingelheim.com.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 01; Vol. 112, pp. 129930. Date of Electronic Publication: 2024 Aug 22.
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2
Akademický článek
mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes.
Autor: Jones AK; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Bajrami B; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Campbell MK; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Erzurumluoglu AM; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Guo Q; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Chen H; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Zhang X; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Zeveleva S; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Kvaskoff D; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Brunner AD; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Muller S; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Gathey V; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Dave RM; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Tanner JW; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Rixen S; Department of Pharmacy, Pharmaceutical Institute, Christian Albrechts University, Kiel, Germany., Struwe MA; Department of Pharmacy, Pharmaceutical Institute, Christian Albrechts University, Kiel, Germany.; Department of Biology, Institute of Zoology-Structural Biology, Christian Albrechts University, Kiel, Germany., Phoenix K; Department of Biotherapeutics Discovery, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Klumph KJ; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Robinson H; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Veyel D; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Muller A; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Noyvert B; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Bartholdy BA; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Steixner-Kumar AA; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Stutzki J; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany.; Data Science Chapter, BI X GmbH, Ingelheim am Rhein, Germany., Drichel D; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany.; Data Science Chapter, BI X GmbH, Ingelheim am Rhein, Germany., Omland S; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany.; Data Science Chapter, BI X GmbH, Ingelheim am Rhein, Germany., Sheehan R; Department of Immunology and Respiratory Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Hill J; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Bretschneider T; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Gottschling D; Department of Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Scheidig AJ; Department of Biology, Institute of Zoology-Structural Biology, Christian Albrechts University, Kiel, Germany., Clement B; Department of Pharmacy, Pharmaceutical Institute, Christian Albrechts University, Kiel, Germany., Giera M; Department of Drug Discovery Sciences, Discovery Science Technologies, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany.; The Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands., Ding Z; Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co., Biberach an der Riss, Germany., Broadwater J; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA., Warren CR; Department of Cardiometabolic Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA.
Publikováno v: Hepatology communications [Hepatol Commun] 2024 Apr 12; Vol. 8 (5). Date of Electronic Publication: 2024 Apr 12 (Print Publication: 2024).
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3
Akademický článek
Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design.
Autor: Ebenhoch R; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Bauer M; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Romig H; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Gottschling D; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Kley JT; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Heine N; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Weber A; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Uphues I; Cardiometabolic Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Nar H; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany., Pautsch A; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 67, 88400 Biberach an der Riss, Germany.
Publikováno v: Acta crystallographica. Section D, Structural biology [Acta Crystallogr D Struct Biol] 2023 Oct 01; Vol. 79 (Pt 10), pp. 871-880. Date of Electronic Publication: 2023 Sep 15.
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4
Akademický článek
Synthesis of 2'-modified N6-methyladenosine phosphoramidites and their incorporation into siRNA.
Autor: Rydzik AM; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany. Electronic address: anna.rydzik@astrazeneca.com., Riether D; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Gottschling D; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Feb 01; Vol. 81, pp. 129126. Date of Electronic Publication: 2023 Jan 09.
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5
Akademický článek
Access to 1'-Amino Carbocyclic Phosphoramidite to Enable Postsynthetic Functionalization of Oligonucleotides.
Autor: Rydzik AM; Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach an der Riss, Germany., Balk R; Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach an der Riss, Germany., Koegler M; Axolabs GmbH, 95326 Kulmbach, Germany., Steinle T; Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach an der Riss, Germany., Riether D; Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach an der Riss, Germany., Gottschling D; Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach an der Riss, Germany.
Publikováno v: Organic letters [Org Lett] 2021 Sep 03; Vol. 23 (17), pp. 6735-6739. Date of Electronic Publication: 2021 Aug 23.
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6
Akademický článek
Epigenetic Modification 6-Methyladenosine Can Impact the Potency and Specificity of siRNA.
Autor: Rydzik AM; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397, Biberach an der Riss, Germany.; Current address: Research and Early Development, Respiratory & Immunology, AstraZeneca, 431 83, Mölndal, Sweden., Gottschling D; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397, Biberach an der Riss, Germany., Simon E; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397, Biberach an der Riss, Germany., Skronska-Wasek W; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397, Biberach an der Riss, Germany., Rippmann JF; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397, Biberach an der Riss, Germany., Riether D; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397, Biberach an der Riss, Germany.
Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2021 Feb 02; Vol. 22 (3), pp. 491-495. Date of Electronic Publication: 2020 Oct 23.
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7
Akademický článek
A Small-Molecule-Responsive Riboswitch Enables Conditional Induction of Viral Vector-Mediated Gene Expression in Mice.
Autor: Strobel B; Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany., Düchs MJ; Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany., Blazevic D; Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany., Rechtsteiner P; Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany., Braun C; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany., Baum-Kroker KS; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany., Schmid B; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany., Ciossek T; Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany., Gottschling D; Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany., Hartig JS; Department of Chemistry, University of Konstanz, Konstanz, 78464, Germany., Kreuz S; Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany.
Publikováno v: ACS synthetic biology [ACS Synth Biol] 2020 Jun 19; Vol. 9 (6), pp. 1292-1305. Date of Electronic Publication: 2020 May 19.
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9
Akademický článek
Nicotinamide Riboside: What It Takes to Incorporate It into RNA.
Autor: Wenzek, Felix1 (AUTHOR), Biallas, Alexander1 (AUTHOR), Müller, Sabine1 (AUTHOR) felix.wenzek@uni-greifswald.de
Publikováno v: Molecules. Aug2024, Vol. 29 Issue 16, p3788. 17p.
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10
Akademický článek
An automated, high-resolution phenotypic assay for adult Brugia malayi and microfilaria.
Autor: Kalwa, Upender1 (AUTHOR), Park, Yunsoo1 (AUTHOR), Kimber, Michael J.2 (AUTHOR), Pandey, Santosh1 (AUTHOR) pandey@iastate.edu
Publikováno v: Scientific Reports. 6/7/2024, Vol. 14 Issue 1, p1-11. 11p.
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