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Traumatic Brain Injury Mechanisms in the Gottingen Minipig in Response to Two Unique Input Modes

Autor: Fievisohn, Elizabeth Mary

Traumatic brain injury (TBI) continues to be a widespread problem in the United States with approximately 1.7 million occurrences annually [1]. Current automotive crash test standards use the Head Injury Criterion (HIC) [2] to assess head injury pote

Externí odkaz: http://hdl.handle.net/10919/64280

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Spontaneous partial recovery of striatal dopaminergic uptake despite nigral cell loss in asymptomatic MPTP-lesioned female minipigs

Autor: Thea P. Lillethorup, Ove Noer, Aage Kristian Olsen Alstrup, Caroline C. Real, Kathrine Stokholm, Majken Borup Thomsen, Hamed Zaer, Dariusz Orlowski, Trine Werenberg Mikkelsen, Andreas N. Glud, Erik Holm Toustrup Nielsen, Anna C. Schacht, Michael Winterdahl, David J. Brooks, Jens Christian H. Sørensen, Anne M. Landau

Publikováno v: Lillethorup, T P, Noer, O, Alstrup, A K O, Real, C C, Stokholm, K, Thomsen, M B, Zaer, H, Orlowski, D, Mikkelsen, T W, Glud, A N, Nielsen, E H T, Schacht, A C, Winterdahl, M, Brooks, D J, Sørensen, J C H & Landau, A M 2022, ' Spontaneous Partial Recovery of Striatal Dopaminergic Uptake Despite Nigral Cell Loss in Asymptomatic MPTP-Lesioned Female Minipigs ', NeuroToxicology . https://doi.org/10.1016/j.neuro.2022.05.006
Lillethorup, T P, Noer, O, Alstrup, A K O, Cristiano Real Gregório, C, Stokholm, K, Thomsen, M, Zaer, H, Orlowski, D, Mikkelsen, T W, Glud, AN, Nielsen, E H T, Schacht, A C, Winterdahl, M, Brooks, D J, Sørensen, J C H & Landau, A 2022, ' Spontaneous partial recovery of striatal dopaminergic uptake despite nigral cell loss in asymptomatic MPTP-lesioned female minipigs ', NeuroToxicology, vol. 91, pp. 166-176 . https://doi.org/10.1016/j.neuro.2022.05.006

The Göttingen minipig is a large animal with a gyrencephalic brain that expresses complex behaviour, making it an attractive model for Parkinson's disease research. Here, we investigate the temporal evolution of presynaptic dopaminergic function for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32413bc32e32832cc10a8107f5514a0f
https://pubmed.ncbi.nlm.nih.gov/35569565

Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain

Autor: Anne M. Landau, Aage Kristian Olsen Alstrup, Michael Winterdahl, Helene Audrain, Albert Gjedde, Gregers Wegener, Ove Noer, Doris J. Doudet

Publikováno v: Landau, A M, Noer, O, Alstrup, A K O, Audrain, H, Wegener, G, Gjedde, A, Doudet, D J & Winterdahl, M 2020, ' Type of Anaesthetic Influences [ 11 C]MDL100,907 Binding to 5HT 2A Receptors in Porcine Brain ', Molecular Imaging and Biology, vol. 22, no. 4, pp. 797-804 . https://doi.org/10.1007/s11307-020-01476-x
Landau, A M, Noer, O, Alstrup, A K O, Audrain, H, Wegener, G, Gjedde, A, Doudet, D J & Winterdahl, M 2020, ' Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain ', Molecular Imaging and Biology, vol. 22, no. 4, pp. 797-804 . https://doi.org/10.1007/s11307-020-01476-x

Purpose: Anaesthesia routinely is used in animal neuroimaging in order to reduce head motion artefacts and minimize the influence of stress. However, anaesthetics can modify radioligand binding profiles at receptor targets studied by positron emissio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d815591c00c6c3b5d8ccf4367a2b1693
https://portal.findresearcher.sdu.dk/da/publications/a01b9ef1-995b-4f4a-bdcc-24381ce37543