Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Gottfried Schmer"'
Autor:
Gottfried Schmer, Craig R. Vocelka, Wayne L. Chandler, Louise O. Soltow, John D. Rosoff, Bruce D. Spiess, R. Pat Cochran, Karyn S. Kunzelman
Publikováno v:
Journal of cardiothoracic and vascular anesthesia. 12(4)
Objectives: To examine whether a second-generation perfluorocarbon (PFC) blood substitute added to the cardiopulmonary bypass (CPB) prime influences complement production. Design: A prospective, randomized, single-blinded, ex vivo model. Setting: A u
Publikováno v:
Journal of biomaterials science. Polymer edition. 6(1)
Polyacrylic acid-IgG polymer (PAA-IgG) activates the classical and alternative pathway of complement as shown by specific Clq-(IgG-PAA) interaction and the generation of C4d, Bb, C3b, C3a and C5a. This water soluble and stable PAA-IgG polymer represe
Publikováno v:
Biochimica et biophysica acta. 1052(3)
An artificial immune complex consisting of IgG covalently bound to polyacrylic acid (PAIGP) was prepared and investigated for its influence on a number of immunological reactions attributed to natural immune complexes. PAIGP consumed complement in a
Publikováno v:
Journal of Controlled Release. 2:375-383
The enzyme l -asparaginase has been used as a drug to treat acute lymphocytic leukemia. However, its effectiveness is limited as a free drug and it is more useful when immobilized. In this study, l -asparaginase has been immobilized onto the porous p
Publikováno v:
Radiation Physics and Chemistry (1977). 25:549-556
The enzyme asparaginase was immobilized onto a porous hollow polypropylene (PP) fiber blood plasma exchange device for the treatment of acute lymphocytic leukemia. The devices were first radiation grafted with polymethacrylic acid (poly(MAAc)). This
Autor:
Eugene A. Hessel, Takeshi Ishitoya, David H. Dillard, Hitoshi Mohri, K. Alvin Merendino, Gottfried Schmer
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 77:277-282
A method of heparinless, oxygenatorless, left heart bypass perfusion rewarming following surface hypothermia, with the use of a closed circuit with 130 ml. prime volume including heat exchanger, has been devised. The use of polyurethane-polyvinyl-gra
Publikováno v:
Biochemical and Biophysical Research Communications. 85:851-856
Heparin fractions of different molecular weights and anticoagulant activities were prepared by chromatography on protamine-Sepharose, and the association constants and stoichiometry for binding to antithrombin III were determined by measurement of en
Publikováno v:
Biochemistry. 15:368-373
A comparison of the physical-chemical properties of human, bovine, and horse antithrombin III has been made. These three plasma proteins are strong inhibitors of bovine factor Xa and form a 1:1 molar complex with this coagulation enzyme. Human, bovin
Purification of indolyl-3-alkane α-hydroxylase by affinity chromatography on indolyl-agarose columns
Autor:
Gottfried Schmer, Joseph Roberts
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Enzymology. 527:264-271
Indolyl-3-alkane alpha-hydroxylase was isolated from soil isolate organism, Pseudomonas XA, by affinity chromatography on indolyl-agarose, using different indole derivatives (L-tryptophan, N-acetyl-L-tryptophan, indole-3-carboxaldehyde and 3-indole-a
Publikováno v:
Circulation. 79:101-106
Previous studies have shown that overall fibrinolytic activity in blood follows a diurnal rhythm with a peak in the morning and a trough in the evening. The purpose of this study was to determine which fibrinolytic factor(s) was responsible for this