Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Gottfried Pohlentz"'
Publikováno v:
Microorganisms, Vol 10, Iss 6, p 1255 (2022)
For five decades it has been known that the pentamer of B subunits (choleragenoid) of the cholera toxin (CT) of Vibrio cholerae binds with high preference to the ganglioside GM1 (II3Neu5Ac-Gg4Cer). However, the exact structures of CT-binding GM1 lipo
Externí odkaz:
https://doaj.org/article/2b72c99b2da74c4d9b9e04f8ba8cb43e
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 6884 (2022)
Enterohemorrhagic Escherichia coli (EHEC) are the human pathogenic subset of Shiga toxin (Stx)-producing E. coli (STEC). EHEC are responsible for severe colon infections associated with life-threatening extraintestinal complications such as the hemol
Externí odkaz:
https://doaj.org/article/5419afa6d70f4cfebbe8f6f01957ae36
Autor:
Nadine Legros, Gottfried Pohlentz, Daniel Steil, Ivan U. Kouzel, Ivan Liashkovich, Alexander Mellmann, Helge Karch, Johannes Müthing
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 8, Pp 1383-1401 (2018)
Shiga toxins (Stxs) are the major virulence factors of Stx-producing Escherichia coli (STEC), which cause hemorrhagic colitis and severe extraintestinal complications due to injury of renal endothelial cells, resulting in kidney failure. Since kidney
Externí odkaz:
https://doaj.org/article/80ae21502f744401be4a43c7f010311a
Autor:
Johanna Detzner, Charlotte Püttmann, Gottfried Pohlentz, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Müthing
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10002 (2021)
Shiga toxin (Stx) is released by enterohemorrhagic Escherichia coli (EHEC) into the human intestinal lumen and transferred across the colon epithelium to the circulation. Stx-mediated damage of human kidney and brain endothelial cells and renal epith
Externí odkaz:
https://doaj.org/article/b3022d15b8e64459a9d43ca7529f5a04
Autor:
Johanna Detzner, Anna-Lena Klein, Gottfried Pohlentz, Elisabeth Krojnewski, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Müthing
Publikováno v:
Toxins, Vol 13, Iss 8, p 529 (2021)
Tubular epithelial cells of the human kidney are considered as targets of Shiga toxins (Stxs) in the Stx-mediated pathogenesis of hemolytic–uremic syndrome (HUS) caused by Stx-releasing enterohemorrhagic Escherichia coli (EHEC). Analysis of Stx-bin
Externí odkaz:
https://doaj.org/article/4ab3f642e38242558cedb74ca51b35a7
Autor:
Johanna Detzner, Elisabeth Krojnewski, Gottfried Pohlentz, Daniel Steil, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Müthing
Publikováno v:
Toxins, Vol 13, Iss 2, p 139 (2021)
Human kidney epithelial cells are supposed to be directly involved in the pathogenesis of the hemolytic–uremic syndrome (HUS) caused by Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli (EHEC). The characterization of the major and min
Externí odkaz:
https://doaj.org/article/7307a806e6dc468ea874324d78fd7d7b
Autor:
Daniel Steil, Catherine-Louise Schepers, Gottfried Pohlentz, Nadine Legros, Jana Runde, Hans-Ulrich Humpf, Helge Karch, Johannes Müthing
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 12, Pp 2322-2336 (2015)
Shiga toxins (Stxs) are produced by enterohemorrhagic Escherichia coli (EHEC), which cause human infections with an often fatal outcome. Vero cell lines, derived from African green monkey kidney, represent the gold standard for determining the cytoto
Externí odkaz:
https://doaj.org/article/9ccc2feecab542dd8e39a80a9b893a63
Publikováno v:
Toxins, Vol 12, Iss 6, p 373 (2020)
The global emergence of clinical diseases caused by enterohemorrhagic Escherichia coli (EHEC) is an issue of great concern. EHEC release Shiga toxins (Stxs) as their key virulence factors, and investigations on the cell-damaging mechanisms toward tar
Externí odkaz:
https://doaj.org/article/ac9daf851b404365973eb3939d00f94a
Autor:
Johanna Detzner, Caroline Gloerfeld, Gottfried Pohlentz, Nadine Legros, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Müthing
Publikováno v:
Microorganisms, Vol 7, Iss 11, p 582 (2019)
Shiga toxin (Stx) producing Escherichia coli (STEC) cause the edema disease in pigs by releasing the swine-pathogenic Stx2e subtype as the key virulence factor. Stx2e targets endothelial cells of animal organs including the kidney harboring the Stx r
Externí odkaz:
https://doaj.org/article/ff5de9bec8e44242820f19984b82b7ec
Autor:
Johannes A Eble, Matthew McDougall, George L Orriss, Stephan Niland, Benjamin Johanningmeier, Gottfried Pohlentz, Markus Meier, Simone Karrasch, Maria Inacia Estevão-Costa, Augusto Martins Lima, Jörg Stetefeld
Publikováno v:
PLoS Biology, Vol 15, Iss 9, p e1002613 (2017)
[This corrects the article DOI: 10.1371/journal.pbio.2001492.].
Externí odkaz:
https://doaj.org/article/fc96bbbb96ae4c83b56f472a046145ba