Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Gottfried, Baier"'
Autor:
Motahareh Solina Safari, Priska Woerl, Carolin Garmsiri, Dido Weber, Marcel Kwiatkowski, Madlen Hotze, Louisa Kuenkel, Luisa Lang, Matthias Erlacher, Ellen Gelpi, Johannes A. Hainfellner, Gottfried Baier, Gabriele Baier-Bitterlich, Stephanie zur Nedden
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 102018- (2024)
Objective: Glucose-1,6-bisphosphate (G-1,6-BP), a byproduct of glycolysis that is synthesized by phosphoglucomutase 2 like 1 (PGM2L1), is particularly abundant in neurons. G-1,6-BP is sensitive to the glycolytic flux, due to its dependence on 1,3-bis
Externí odkaz:
https://doaj.org/article/56bca8caec1144bc82e557e68d31c3f2
Autor:
Jiří Koutník, Verena Neururer, Thomas Gruber, Sebastian Peer, Natascha Hermann-Kleiter, William J. Olson, Verena Labi, Michael Leitges, Gottfried Baier, Kerstin Siegmund
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background The Protein kinase D3 (PKD3) has been implicated in signal transduction downstream of the T cell receptor (TCR). However, its role for the activation of primary T lymphocytes has not been elucidated so far. Methods Expression of P
Externí odkaz:
https://doaj.org/article/d2cd8faf7d8a4d44a77535a25aa7c4b8
Autor:
Stephanie zur Nedden, Motahareh Solina Safari, Friedrich Fresser, Klaus Faserl, Herbert Lindner, Bettina Sarg, Gottfried Baier, Gabriele Baier-Bitterlich
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1599 (2023)
We recently identified protein kinase N1 (PKN1) as a negative gatekeeper of neuronal AKT protein kinase activity during postnatal cerebellar development. The developing cerebellum is specifically vulnerable to hypoxia-ischemia (HI), as it occurs duri
Externí odkaz:
https://doaj.org/article/6d22c3c3c7bf45f19f824ebd1871f337
Autor:
William J. Olson, Bojana Jakic, Verena Labi, Johannes Woelk, Emmanuel Derudder, Gottfried Baier, Natascha Hermann-Kleiter
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
B cells are key mediators of humoral immunity. Mature B cells fall into various sub-classes that can be separated by their ontogeny, expression of cell surface markers, anatomical location, and function. B1 subsets play important roles in natural imm
Externí odkaz:
https://doaj.org/article/e2139a73e90d43b3a56eebf28e146f74
Autor:
Bojana Jakic, William J. Olson, Kerstin Siegmund, Victoria Klepsch, Janine Kimpel, Verena Labi, Dietmar Zehn, Gottfried Baier, Natascha Hermann-Kleiter
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)
Abstract Memory formation is a hallmark of T cell-mediated immunity, but how differentiation into either short-lived effector cells (SLECs, CD127−KLRG1+) or memory precursors cells (MPECs, CD127+KLRG1−) and subsequent regulation of long-term memo
Externí odkaz:
https://doaj.org/article/16f2165276a045e28562fa2d8f16d12a
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
This review focuses on current clinical and immunological aspects of cerebral malaria induced by Plasmodium falciparum infection. Albeit many issues concerning the inflammatory responses remain unresolved and need further investigations, current know
Externí odkaz:
https://doaj.org/article/a89f5c1a881f405d98f38a623b20f75e
Autor:
Victoria Klepsch, Maria Pommermayr, Dominik Humer, Natascha Brigo, Natascha Hermann-Kleiter, Gottfried Baier
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract Background NR2F6 has been proposed as an alternative cancer immune checkpoint in the effector T cell compartment. However, a realistic assessment of the in vivo therapeutic potential of NR2F6 requires acute depletion. Methods Employing prima
Externí odkaz:
https://doaj.org/article/c575c24f42374fb7867a1284d6d769bc
Autor:
Tajana Sajinovic, Gottfried Baier
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 1, p 13 (2023)
Following gene expansion during evolution, today’s phylogenetic tree of the NR2F family of nuclear orphan receptors in mammals is represented by three different isoforms: NR2F1, NR2F2, and NR2F6. Structural analysis of the NR2F family members has r
Externí odkaz:
https://doaj.org/article/a317f1991dae47919082e3aa0da1a9e2
Autor:
Nikolaus Thuille, Kerstin Siegmund, Victoria Klepsch, Jacqueline Schörgenhuber, Sarah Danklmaier, Michael Leitges, Gottfried Baier
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-11 (2019)
Abstract Background Protein kinase C θ has been established as an important signaling intermediate in T-effector-cell activation and survival pathways by controlling activity of the key transcription factors NF-κB and NFAT. Previous studies identif
Externí odkaz:
https://doaj.org/article/d39615c71aa645ed92348aed297e5252
Autor:
Jenny Landsberg, Dominik Wolf, Peter Krawitz, Gottfried Baier, Peter Brossart, Oliver Schanz, Isabelle Cornez, Sowmya Parampalli Yajnanarayana, Friederike Sophie David, Sebastian Peer, Thomas Gruber, Annkristin Heine
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background Casitas B lymphoma-b (Cbl-b) is a central negative regulator of cytotoxic T and natural killer (NK) cells and functions as an intracellular checkpoint in cancer. In particular, Th9 cells support mast cell activation, promote dendritic cell
Externí odkaz:
https://doaj.org/article/e4eebec671b74e7f85ca2ee40269a165