Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study

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Publikováno v: In The Lancet Neurology September 2024 23(9):901-912

Discovery of [¹¹C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators.

Autor: Perkins, James J., McQuade, Paul, Bungard, Christopher J., Diamond, Tracy L., Gantert, Liza T., Gotter, Anthony L., Hanney, Barbara, Hills, Ivory D., Hurzy, Danielle M., Joshi, Aniket, Kern, Jonathan T., Schlegel, Kelly-Ann S., Manikowski, Jesse J., Meng, Zhaoyang, O'Brien, Julie A., Roecker, Anthony J., Smith, Sean M., Uslaner, Jason M., Hostetler, Eric, Meissner, Robert S.

Publikováno v: ACS Medicinal Chemistry Letters; 7/13/2023, Vol. 14 Issue 7, p986-992, 7p

Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists

Autor: Skudlarek, Jason W., DiMarco, Christina N., Babaoglu, Kerim, Roecker, Anthony J., Bruno, Joseph G., Pausch, Mark A., O'Brien, Julie A., Cabalu, Tamara D., Stevens, Joanne, Brunner, Joseph, Tannenbaum, Pamela L., Wuelfing, W. Peter, Garson, Susan L., Fox, Steven V., Savitz, Alan T., Harrell, Charles M., Gotter, Anthony L., Winrow, Christopher J., Renger, John J., Kuduk, Scott D., Coleman, Paul J.

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 15 March 2017 27(6):1364-1370

Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology

Autor: Stump, Craig A., Cooke, Andrew J., Bruno, Joseph, Cabalu, Tamara D., Gotter, Anthony L., Harell, C. Meacham, Kuduk, Scott D., McDonald, Terrence P., O’Brien, Julie, Renger, John J., Williams, Peter D., Winrow, Christopher J., Coleman, Paul J.

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 1 December 2016 26(23):5809-5814

Pharmacological Validation of Candidate Causal Sleep Genes Identified in an N2 Cross.

Autor: Brunner, Joseph I.¹ (AUTHOR), Gotter, Anthony L.¹ (AUTHOR), Millstein, Joshua² (AUTHOR), Garson, Susan¹ (AUTHOR), Binns, Jacquelyn³ (AUTHOR), Fox, Steven V.³ (AUTHOR), Savitz, Alan T.³ (AUTHOR), Yang, He S.⁴ (AUTHOR), Fitzpatrick, Karrie⁴ (AUTHOR), Zhou, Lili⁴ (AUTHOR), Owens, Joseph R.⁴ (AUTHOR), Webber, Andrea L.⁵ (AUTHOR), Vitaterna, Martha H.⁴ (AUTHOR), Kasarskis, Andrew² (AUTHOR), Uebele, Victor N.⁶ (AUTHOR), Turek, Fred⁴ (AUTHOR), Renger, John J.¹ (AUTHOR), Winrow, Christopher J.¹ (AUTHOR) christopher_winrow@merck.com

Publikováno v: Journal of Neurogenetics. 2011, Vol. 25 Issue 4, p167-181. 15p.