Zobrazeno 1 - 10
of 291
pro vyhledávání: '"Gosse J. Adema"'
Autor:
Daan F. Boreel, Anne P.M. Beerkens, Sandra Heskamp, Milou Boswinkel, Johannes P.W. Peters, Gosse J. Adema, Paul N. Span, Johan Bussink
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 49, Iss , Pp 100875- (2024)
Introduction: Tumor hypoxia is a feature of many solid malignancies and is known to cause radio resistance. In recent years it has become clear that hypoxic tumor regions also foster an immunosuppressive phenotype and are involved in immunotherapy re
Externí odkaz:
https://doaj.org/article/cae6230e8058466b98f4a09faac3e1ce
Autor:
Mariana Reste, Kristi Ajazi, Ayca Sayi-Yazgan, Radmila Jankovic, Biljana Bufan, Sven Brandau, Espen S. Bækkevold, Florent Petitprez, Malin Lindstedt, Gosse J. Adema, Catarina R. Almeida
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Tertiary Lymphoid Structures (TLS) are organized aggregates of immune cells such as T cells, B cells, and Dendritic Cells (DCs), as well as fibroblasts, formed postnatally in response to signals from cytokines and chemokines. Central to the function
Externí odkaz:
https://doaj.org/article/02a9a8a5f7224814a31a9a5c36c57470
Autor:
Anne P. M. Beerkens, Daan F. Boreel, James A. Nathan, Jiri Neuzil, Gang Cheng, Balaraman Kalyanaraman, Micael Hardy, Gosse J. Adema, Sandra Heskamp, Paul N. Span, Johan Bussink
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-10 (2024)
Abstract Background Hypoxia is a common feature of many solid tumors and causes radiotherapy and immunotherapy resistance. Pharmacological inhibition of oxidative phosphorylation (OXPHOS) has emerged as a therapeutic strategy to reduce hypoxia. Howev
Externí odkaz:
https://doaj.org/article/6158a99077a34dd2a03b9ab6923fa43f
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The T cell is an immune cell subset highly effective in eliminating cancer cells. Cancer immunotherapy empowers T cells and occupies a solid position in cancer treatment. The response rate, however, remains relatively low (
Externí odkaz:
https://doaj.org/article/a630afd5daf4418ca943b370e79f88a0
Autor:
Lenneke A. M. Cornelissen, Kim C. M. Santegoets, Esther D. Kers-Rebel, Sandra A. J. F. H. Bossmann, Mark Ter Laan, Daniel Granado, Gosse J. Adema
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 953 (2024)
The tumor microenvironment of glioblastoma IDH-wildtype is highly immune suppressive and is characterized by a strong component of myeloid-derived suppressor cells (MDSCs). To interfere with the immune suppressive functions of MDSCs, a comprehensive
Externí odkaz:
https://doaj.org/article/97a25e7e2fbb4e2a8bccf18503ec2409
Autor:
Katrin Rabold, Martijn Zoodsma, Inge Grondman, Yunus Kuijpers, Manita Bremmers, Martin Jaeger, Bowen Zhang, Willemijn Hobo, Han J. Bonenkamp, Johannes H. W. de Wilt, Marcel J. R. Janssen, Lenneke A. M. Cornelissen, Ilse C. H. van Engen-van Grunsven, Willem J. M. Mulder, Jan W. A. Smit, Gosse J. Adema, Mihai G. Netea, Yang Li, Cheng-Jian Xu, Romana T. Netea-Maier
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Myeloid cells contribute to the tumor microenvironment of thyroid cancers, but their functional relevance is lesser known. Here authors show that myeloid cells infiltrating non-medullary thyroid carcinomas upregulate their antigen presentation-relate
Externí odkaz:
https://doaj.org/article/8df2ed731e6144a6a49c050153ca4af0
Autor:
Renske J. E. van den Bijgaart, Vera E. Mekers, Fabian Schuurmans, Tonke K. Raaijmakers, Melissa Wassink, Andor Veltien, Erik Dumont, Arend Heerschap, Jurgen J. Fütterer, Gosse J. Adema
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionIn situ tumor ablation releases a unique repertoire of antigens from a heterogeneous population of tumor cells. High-intensity focused ultrasound (HIFU) is a completely noninvasive ablation therapy that can be used to ablate tumors either
Externí odkaz:
https://doaj.org/article/43a17c9ddbdb4061898a346b131c9865
Autor:
Tonke K. Raaijmakers, Renske J. E. van den Bijgaart, Gert Jan Scheffer, Marleen Ansems, Gosse J. Adema
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Background Immunotherapy is now considered as the new pillar in treatment of cancer patients. Dendritic cells (DCs) play an essential role in stimulating anti-tumor immune responses, as they are capable of cross-presenting exogenous tumor antigens in
Externí odkaz:
https://doaj.org/article/3dcde85997d6466b991b59d9b7fbe3b9
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors that recognize sialoglycans – sialic acid containing glycans that are abundantly present on cell membranes. Siglecs are expressed on most immune cells and can modul
Externí odkaz:
https://doaj.org/article/0fc23e2420a546629d0454deae6bc930
Autor:
Renske J. E. van den Bijgaart, Fabian Schuurmans, Jurgen J. Fütterer, Marcel Verheij, Lenneke A. M. Cornelissen, Gosse J. Adema
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In situ tumor ablation techniques, like radiotherapy, cryo- and heat-based thermal ablation are successfully applied in oncology for local destruction of tumor masses. Although diverse in technology and mechanism of inducing cell death, ablative tech
Externí odkaz:
https://doaj.org/article/b66c11129a6d466f8622f99d20633085