Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Goss Stryker Kauffman"'
Autor:
Zhongguo Wang, Goss Stryker Kauffman, Stephen Hubbs, Shawn Fessler, Lili Yao, Jennifer Castro, George P. Luke, Lu Wei, Mark T. Kershaw, Matthew W. Martin, Shawn Schiller, Crystal McKinnon, Angela V. Toms, Kenneth W. Bair, David S. Millan, David R. Lancia, Deepali Gotur, Li Hongbin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1001-1006
The discovery, structure-activity relationships, and optimization of a novel class of fatty acid synthase (FASN) inhibitors is reported. High throughput screening identified a series of substituted piperazines with structural features that enable int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e1607021e1e0b594aba77304e55e00
https://doi.org/10.1016/j.bmcl.2019.02.012
https://doi.org/10.1016/j.bmcl.2019.02.012
Autor:
K.J. Barr, A. Ericsson, Zhongguo Wang, David R. Lancia, A. Clarke, R.B. Diebold, S. Ashwell, George P. Luke, Deepali Gotur, Wei Lu, Jian Lin, H.R. Josephine, M. Katz, D. Walker, A.M. Campbell, Goss Stryker Kauffman, L. Yao, Angela V. Toms, Caravella Justin Andrew, H. Diep, Jennifer Castro, Kenneth W. Bair, E. Fritzen, Christopher J. Dinsmore, Stephen Hubbs, Le Wang, G.R. Gustafson, Tatiana E. Shelekhin, Mark T. Kershaw
Publikováno v:
Journal of medicinal chemistry. 62(14)
Mutations at the arginine residue (R132) in isocitrate dehydrogenase 1 (IDH1) are frequently identified in various human cancers. Inhibition of mutant IDH1 (mIDH1) with small molecules has been clinically validated as a promising therapeutic treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74eee5a37b35c08111cdd42f3f0e0830
https://pubmed.ncbi.nlm.nih.gov/31199148
https://pubmed.ncbi.nlm.nih.gov/31199148
Autor:
Patrick Vincent, Joel Morris, Francis Rajamohan, Elisabeth Knauth, Shaughnessy Robinson, Tracey Clark, Liuqing Wei, Merin Troutman, Shefali Kakar, Jayvardhan Pandit, Matthew Corbett, Blaise Lippa, Gonghua Pan, Elsa G. Barbacci-Tobin, Eric S. Marr, Gary Borzillo, Goss Stryker Kauffman, Deborah A. Baker, Ekaterina Kozina, Chao Li
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3359-3363
Based on a high throughput screening hit, pyrrolopyrimidine inhibitors of the Akt kinase are explored. X-ray co-crystal structures of two lead series results in the understanding of key binding interactions, the design of new lead series, and enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced956a1a9ce830557eb16e29f87bb43
https://doi.org/10.1016/j.bmcl.2008.04.034
https://doi.org/10.1016/j.bmcl.2008.04.034
Autor:
Duncan Walker, Monica A. Alvarez Morales, Crystal McKinnon, David S. Millan, Stephen Hubbs, Torsten Herbertz, Jaime Escobedo, Katherine J. Kayser-Bricker, Adam C. Talbot, Mark T. Kershaw, Rachel L. Mendes, Kevin Foley, Kristina R Muskiewicz, Lili Yao, George P. Luke, Grace L. Williams, Matthew W. Martin, Patricia Soulard, Goss Stryker Kauffman, Shawn Schiller, Kenneth J Barr, Christopher J. Dinsmore, Daniel Cardillo, Alan Collis
Publikováno v:
Blood. 126:1367-1367
Members of the Bromodomain and Extra-Terminal (BET) family of bromodomain-containing proteins (BRD2, BRD3, BRD4, and BRDT) bind to acetylated lysine residues on histone tails and act as epigenetic readers to regulate chromatin structure and gene expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::322f04209d682fe72dbe8dab8292f75d
https://doi.org/10.1182/blood.v126.23.1367.1367
https://doi.org/10.1182/blood.v126.23.1367.1367
Autor:
Stefanus J. Steyn, Leslie R. Pustilnik, Goss Stryker Kauffman, Courtney Williams, Tricia Ann Kwan, Ling Ma, Mary Campbell, Jun Xiao, Jinshan Chen, Chunyan Su, William M. Hungerford, James D. Moyer, Joel T. Arcari, Blaise Lippa, Samit Kumar Bhattacharya, Xumiao Zhao
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(11)
The synthesis and biological evaluation of potent and selective inhibitors of the erbB2 kinase is presented. Based on the 4-anilinoquinazoline chemotype, the syntheses of several new series of erbB2 inhibitors are described with quinazoline and pyrid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e4e80ef6813758a49387ee5c5efe54
https://pubmed.ncbi.nlm.nih.gov/17398092
https://pubmed.ncbi.nlm.nih.gov/17398092