Zobrazeno 1 - 10 of 282 pro vyhledávání: '"Gosmini R"'
1
Akademický článek
Discovery of GLPG2737, a Potent Type 2 Corrector of CFTR for the Treatment of Cystic Fibrosis in Combination with a Potentiator and a Type 1 Co-corrector.
Autor: Pizzonero M; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Akkari R; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Bock X; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Gosmini R; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., De Lemos E; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Duthion B; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Newsome G; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Mai TT; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Roques V; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Jary H; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Lefrancois JM; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Cherel L; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Quenehen V; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Babel M; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Merayo N; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Bienvenu N; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Mammoliti O; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium., Coti G; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium., Palisse A; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium., Cowart M; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064-1802, United States., Shrestha A; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064-1802, United States., Greszler S; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064-1802, United States., Van Der Plas S; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium., Jansen K; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium., Claes P; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium., Jans M; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium., Gees M; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium., Borgonovi M; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., De Wilde G; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium., Conrath K; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Apr 11; Vol. 67 (7), pp. 5216-5232. Date of Electronic Publication: 2024 Mar 25.
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2
Akademický článek
Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312.
Autor: Temal-Laib T; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Peixoto C; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Desroy N; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., De Lemos E; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Bonnaterre F; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Bienvenu N; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Picolet O; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Sartori E; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Bucher D; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., López-Ramos M; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Roca Magadán C; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Laenen W; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium., Flower T; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Mollat P; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Bugaud O; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Touitou R; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Pereira Fernandes A; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium., Lavazais S; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Monjardet A; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Borgonovi M; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Gosmini R; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Brys R; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium., Amantini D; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., De Vos S; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium., Andrews M; Galapagos NV, Generaal De Wittelaan L11, A3, 2800 Mechelen, Belgium.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jan 11; Vol. 67 (1), pp. 380-401. Date of Electronic Publication: 2023 Dec 26.
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3
Akademický článek
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4
Akademický článek
Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis.
Autor: Brebion F; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Gosmini R; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Deprez P; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Varin M; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Peixoto C; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Alvey L; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Jary H; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Bienvenu N; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Triballeau N; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Blanque R; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Cottereaux C; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Christophe T; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Vandervoort N; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Mollat P; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Touitou R; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Leonard P; Structural Biology, Charles River, Chesterford Research Park, CB10 1XL Saffron Walden, United Kingdom., De Ceuninck F; Institut de Recherches Servier, Center for Therapeutic Innovation, Immuno-inflammatory Disease, 78290 Croissy sur Seine, France., Botez I; Institut de Recherches Servier, Chemistry Center of Excellence, 78290 Croissy sur Seine, France., Monjardet A; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., van der Aar E; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Amantini D; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Mar 25; Vol. 64 (6), pp. 2937-2952. Date of Electronic Publication: 2021 Mar 15.
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5
Akademický článek
Discovery of 9-Cyclopropylethynyl-2-(( S )-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1- a ]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.
Autor: Labéguère F; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Dupont S; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Alvey L; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Soulas F; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Newsome G; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Tirera A; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Quenehen V; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Mai TTT; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Deprez P; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Blanqué R; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Oste L; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Le Tallec S; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., De Vos S; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Hagers A; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Vandevelde A; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Nelles L; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Vandervoort N; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Conrath K; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Christophe T; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., van der Aar E; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Wakselman E; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Merciris D; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Cottereaux C; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., da Costa C; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Saniere L; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Clement-Lacroix P; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France., Jenkins L; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom., Milligan G; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom., Fletcher S; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Brys R; Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium., Gosmini R; Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Nov 25; Vol. 63 (22), pp. 13526-13545. Date of Electronic Publication: 2020 Sep 23.
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7
Akademický článek
The Versatility of Collagen in Pharmacology: Targeting Collagen, Targeting with Collagen.
Autor: Revert-Ros, Francisco1 (AUTHOR) fj.revert@ucv.es, Ventura, Ignacio1 (AUTHOR), Prieto-Ruiz, Jesús A.1 (AUTHOR), Hernández-Andreu, José Miguel1 (AUTHOR), Revert, Fernando1 (AUTHOR) fernando.revert@ucv.es
Publikováno v: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 12, p6523. 29p.
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8
Akademický článek
GLPG1972: a potent, selective, orally available adamts-5 inhibitor for the treatment of OA
Autor: Clement-Lacroix, P. †, Little, C. ‡, Meurisse, S. †, Blanqué, R. †, Mollat, P. †, Brebion, F. †, Gosmini, R. †, De Ceuninck, F. §, Botez, I. §, Lepescheux, L. †, van der Aar, E. ‖, Christophe, T. ‖, Vandervoort, N. ‖, Cottereaux, C. †, Comas, D. †, Deprez, P. †, Amantini, D. †
Publikováno v: In Osteoarthritis and Cartilage April 2017 25 Supplement 1:S58-S59
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9
Akademický článek
Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84.
Autor: Mahmud ZA; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, United Kingdom., Jenkins L; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, United Kingdom., Ulven T; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230, Odense M, Denmark., Labéguère F; Galapagos SASU, 102 Avenue Gaston Roussel, 93230, Romainville, France.; Evotec, 195 Route d'Espagne, 31100, Toulouse, France., Gosmini R; Galapagos SASU, 102 Avenue Gaston Roussel, 93230, Romainville, France., De Vos S; Galapagos NV, Generaal De Wittelaan L11 A3, 2800, Mechelen, Belgium., Hudson BD; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, United Kingdom., Tikhonova IG; School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast, BT9 7BL, United Kingdom., Milligan G; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, United Kingdom. Graeme.Milligan@glasgow.ac.uk.
Publikováno v: Scientific reports [Sci Rep] 2017 Dec 20; Vol. 7 (1), pp. 17953. Date of Electronic Publication: 2017 Dec 20.
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10
Akademický článek
Function and regulation of GPR84 in human neutrophils.
Autor: Forsman H; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden., Dahlgren C; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Mårtensson J; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Björkman L; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Sundqvist M; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 May; Vol. 181 (10), pp. 1536-1549. Date of Electronic Publication: 2023 Mar 27.
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