A noncoding single-nucleotide polymorphism at 8q24 drives IDH1 -mutant glioma formation.

Autor: Yanchus C; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Drucker KL; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Kollmeyer TM; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Tsai R; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Winick-Ng W; Max-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, 13092 Berlin, Germany., Liang M; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Malik A; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Pawling J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., De Lorenzo SB; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Ali A; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Decker PA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Kosel ML; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Panda A; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Al-Zahrani KN; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Jiang L; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Browning JWL; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Lowden C; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Geuenich M; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Hernandez JJ; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Gosio JT; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Ahmed M; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Loganathan SK; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Berman J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Trcka D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Michealraj KA; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Fortin J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Carson B; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Hollingsworth EW; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Jacinto S; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Mazrooei P; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Zhou L; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Elia A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Lupien M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., He HH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Murphy DJ; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, Scotland, UK.; Cancer Research UK Beatson Institute, Glasgow G61 1BD, Scotland, UK., Wang L; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Abyzov A; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Dennis JW; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Maass PG; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Campbell K; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Wilson MD; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Lachance DH; Departments of Neurology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Wrensch M; Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA., Wiencke J; Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA., Mak T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Pennacchio LA; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA.; Comparative Biochemistry Program, University of California, Berkeley, CA 94720, USA.; US Department of Energy Joint Genome Institute, Berkeley, CA 94720, USA., Dickel DE; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA., Visel A; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA.; US Department of Energy Joint Genome Institute, Berkeley, CA 94720, USA.; School of Natural Sciences, University of California, Merced, CA 95343, USA., Wrana J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Taylor MD; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Zadeh G; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Dirks P; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Eckel-Passow JE; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Attisano L; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada., Pombo A; Max-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, 13092 Berlin, Germany.; Institute of Biology, Humboldt University of Berlin, 10115 Berlin, Germany., Ida CM; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Kvon EZ; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Jenkins RB; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

Publikováno v: Science (New York, N.Y.) [Science] 2022 Oct 07; Vol. 378 (6615), pp. 68-78. Date of Electronic Publication: 2022 Oct 06.

A microdeletion event at 19q13.43 in IDH-mutant astrocytomas is strongly correlated with MYC overexpression.

Autor: Ülgen, Ege^1,2 (AUTHOR), Gerlevik, Umut^3,4 (AUTHOR), Gerlevik, Sıla⁵ (AUTHOR), Oktay, Yavuz^6,7 (AUTHOR), Sezerman, Osman Uğur¹ (AUTHOR), Turcan, Şevin⁸ (AUTHOR), Ozduman, Koray² (AUTHOR) koray.ozduman@icloud.com

Publikováno v: Acta Neuropathologica Communications. 6/14/2024, Vol. 12 Issue 1, p1-11. 11p.

Optimization of differential filtration-based mitochondrial isolation for mitochondrial transplant to cerebral organoids.

Autor: Bodenstein, David F.¹ (AUTHOR), Powlowski, Pavel¹ (AUTHOR), Zachos, Kassandra A.¹ (AUTHOR), El Soufi El Sabbagh, Dana¹ (AUTHOR), Jeong, Hyunjin¹ (AUTHOR), Attisano, Liliana^2,3 (AUTHOR), Edgar, Landon^1,4 (AUTHOR), Wallace, Douglas C.^5,6,7 (AUTHOR), Andreazza, Ana Cristina^1,8 (AUTHOR) ana.andreazza@utoronto.ca

Publikováno v: Stem Cell Research & Therapy. 8/15/2023, Vol. 14 Issue 1, p1-16. 16p.

A FACILE METHOD TO GENERATE CEREBRAL ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS.

Autor: Simorgh, Susan^1,2,3, Mousavi, Seyed Ahmad², To, San Kit⁴, Pasque, Vincent⁴, Wierda, Keimpe^5,6, Vervliet, Tim⁷, Yeganeh, Meghdad², Pooyan, Paria², Chai, Yoke Chin³ yokechin.chai@kuleuven.be, Verfaillie, Catherine³ catherine.verfaillie@kuleuven.be, Baharvand, Hossein^1,2 h.baharvand@royan-rc.ac.ir

Publikováno v: EXCLI Journal. 2023, Vol. 22, p1055-1076. 22p.

In vivo development and single‐cell transcriptome profiling of human brain organoids.

Autor: Huang, Shichao¹ (AUTHOR) huangshichao@sibcb.ac.cn, Huang, Fei² (AUTHOR), Zhang, Huiying² (AUTHOR), Yang, Yongfeng¹ (AUTHOR), Lu, Juan¹ (AUTHOR), Chen, Jiadong³ (AUTHOR), Shen, Li^2,4,5 (AUTHOR) li_shen@zju.edu.cn, Pei, Gang^1,6,7 (AUTHOR)

Publikováno v: Cell Proliferation. Mar2022, Vol. 55 Issue 3, p1-10. 10p.