Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo

Autor: Simon, CS, Downes, DJ, Gosden, ME, Telenius, J, Higgs, DR, Hughes, JR, Costello, I, Bikoff, EK, Robertson, E

The T-box transcription factor (TF) Eomes is a key regulator of cell fate decisions during early mouse development. The cis-acting regulatory elements that direct expression in the anterior visceral endoderm (AVE), primitive streak (PS) and definitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::602fc931882bda48f68372ca7d4cf630
https://doi.org/10.1242/dev.147322

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale.

Autor: Downes DJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Beagrie RA; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Gosden ME; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Telenius J; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Carpenter SJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Nussbaum L; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., De Ornellas S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK., Sergeant M; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Eijsbouts CQ; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Schwessinger R; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Kerry J; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Roberts N; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Shivalingam A; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK., El-Sagheer A; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK., Oudelaar AM; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Brown T; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK., Buckle VJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Davies JOJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Hughes JR; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. jim.hughes@imm.ox.ac.uk.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. jim.hughes@imm.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2021 Jan 22; Vol. 12 (1), pp. 531. Date of Electronic Publication: 2021 Jan 22.