Improving combination therapies: targeting A2B-adenosine receptor to modulate metabolic tumor microenvironment and immunosuppression.

Autor: Evans JV; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.; Department of Pathology, Anatomy, and Laboratory Medicine, School of Medicine, West Virginia University, Morgantown, WV, USA., Suman S; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Goruganthu MUL; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Tchekneva EE; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Guan S; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Arasada RR; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.; Pfizer Inc, New York, NY, USA., Antonucci A; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Piao L; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Ilgisonis I; N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia., Bobko AA; In Vivo Multifunctional Magnetic Resonance Center, West Virginia University, Morgantown, WV, USA.; Department of Biochemistry, West Virginia University, Morgantown, WV, USA., Driesschaert B; In Vivo Multifunctional Magnetic Resonance Center, West Virginia University, Morgantown, WV, USA.; Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV, USA., Uzhachenko RV; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN, USA.; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Hoyd R; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Samouilov A; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Amann J; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Wu R; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Wei L; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Pallerla A; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Ryzhov SV; Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME, USA., Feoktistov I; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN, USA., Park KP; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN, USA., Kikuchi T; Division of Gastroenterology, Department of Internal Medicine, Sapporo Shirakabadai Hospital, Sapporo, Japan., Castro J; Palobiofarma SL, Barcelona, Spain., Ivanova AV; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN, USA.; School of Graduate Studies, Meharry Medical College, Nashville, TN, USA., Kanagasabai T; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN, USA.; School of Graduate Studies, Meharry Medical College, Nashville, TN, USA., Owen DH; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Spakowicz DJ; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Zweier JL; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Carbone DP; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Novitskiy SV; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA., Khramtsov VV; In Vivo Multifunctional Magnetic Resonance Center, West Virginia University, Morgantown, WV, USA.; Department of Biochemistry, West Virginia University, Morgantown, WV, USA., Shanker A; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN, USA.; School of Graduate Studies, Meharry Medical College, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.; V anderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University, Nashville, TN, USA., Dikov MM; Department of Internal Medicine, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

Publikováno v: Journal of the National Cancer Institute [J Natl Cancer Inst] 2023 Nov 08; Vol. 115 (11), pp. 1404-1419.

Specific Targeting of Notch Ligand-Receptor Interactions to Modulate Immune Responses: A Review of Clinical and Preclinical Findings.

Autor: Goruganthu MUL; Department of Internal Medicine, James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, United States., Shanker A; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United States.; Vanderbilt-Ingram Cancer Center, Nashville, TN, United States., Dikov MM; Department of Internal Medicine, James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, United States., Carbone DP; Department of Internal Medicine, James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2020 Aug 14; Vol. 11, pp. 1958. Date of Electronic Publication: 2020 Aug 14 (Print Publication: 2020).

Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T cell immunity.

Autor: Tchekneva EE; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Wexner Medical Center and The James Comprehensive Cancer Center, 460 W 12th Ave, 484 BRT, Columbus, OH, 43210, USA., Goruganthu MUL; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Wexner Medical Center and The James Comprehensive Cancer Center, 460 W 12th Ave, 484 BRT, Columbus, OH, 43210, USA., Uzhachenko RV; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, 2005 Harold D. West Basic Sciences Building, 1023 21st Ave N, Nashville, 37208, TN, USA., Thomas PL; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, 2005 Harold D. West Basic Sciences Building, 1023 21st Ave N, Nashville, 37208, TN, USA.; Department of Microbiology, Immunology and Physiology, Meharry Medical College School of Medicine, Nashville, USA.; School of Graduate Studies and Research, Meharry Medical College, Nashville, TN, USA., Antonucci A; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Wexner Medical Center and The James Comprehensive Cancer Center, 460 W 12th Ave, 484 BRT, Columbus, OH, 43210, USA., Chekneva I; Sechenov First Moscow State Medical University, Moscow, Russia., Koenig M; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Wexner Medical Center and The James Comprehensive Cancer Center, 460 W 12th Ave, 484 BRT, Columbus, OH, 43210, USA., Piao L; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Wexner Medical Center and The James Comprehensive Cancer Center, 460 W 12th Ave, 484 BRT, Columbus, OH, 43210, USA., Akhter A; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Wexner Medical Center and The James Comprehensive Cancer Center, 460 W 12th Ave, 484 BRT, Columbus, OH, 43210, USA., de Aquino MTP; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, 2005 Harold D. West Basic Sciences Building, 1023 21st Ave N, Nashville, 37208, TN, USA., Ranganathan P; Division of Hematology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Long N; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA., Magliery T; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA., Valujskikh A; Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, USA., Evans JV; Department of Pathology, West Virginia University, Morgantown, WV, USA., Arasada RR; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Wexner Medical Center and The James Comprehensive Cancer Center, 460 W 12th Ave, 484 BRT, Columbus, OH, 43210, USA., Massion PP; Department of Medicine, Vanderbilt University, Nashville, TN, USA., Carbone DP; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Wexner Medical Center and The James Comprehensive Cancer Center, 460 W 12th Ave, 484 BRT, Columbus, OH, 43210, USA., Shanker A; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, 2005 Harold D. West Basic Sciences Building, 1023 21st Ave N, Nashville, 37208, TN, USA. ashanker@mmc.edu.; School of Graduate Studies and Research, Meharry Medical College, Nashville, TN, USA. ashanker@mmc.edu.; Host-Tumor Interactions Research Program, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University, Nashville, TN, USA. ashanker@mmc.edu.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University, Nashville, TN, USA. ashanker@mmc.edu., Dikov MM; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Wexner Medical Center and The James Comprehensive Cancer Center, 460 W 12th Ave, 484 BRT, Columbus, OH, 43210, USA. Mikhail.Dikov@OSUMC.edu.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2019 Apr 02; Vol. 7 (1), pp. 95. Date of Electronic Publication: 2019 Apr 02.