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Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.

Autor: Hosey AM, Gorski JJ, Murray MM, Quinn JE, Chung WY, Stewart GE, James CR, Farragher SM, Mulligan JM, Scott AN, Dervan PA, Johnston PG, Couch FJ, Daly PA, Kay E, McCann A, Mullan PB, Harkin DP, Hosey, Alison M, Gorski, Julia J

Publikováno v: JNCI: Journal of the National Cancer Institute; 11/21/2007, Vol. 99 Issue 22, p1683-1694, 12p

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Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability

Autor: Manuel Salto-Tellez, Andrea Pellagatti, Kienan I. Savage, Dennis J. McCance, Gareth W. Irwin, W. Glenn McCluggage, D. Paul Harkin, Derek J. Richard, Eliana M. Barros, Jacqueline Boultwood, Julia J. Gorski, Giuseppe Schettino, Alexander J. Powell, Lorenzo Manti, Natalia Lukashchuk, Simon S. McDade

Publikováno v: Molecular Cell
Savage, K I, Gorski, J J, Barros, E M, Irwin, G W, Manti, L, Powell, A J, Pellagatti, A, Lukashchuk, N, McCance, D J, McCluggage, W G, Schettino, G, Salto-Tellez, M, Boultwood, J, Richard, D J, McDade, S S & Harkin, D P 2014, ' Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability ', Molecular Cell, vol. 54, no. 3, pp. 445-459 . https://doi.org/10.1016/j.molcel.2014.03.021

Summary Mutations within BRCA1 predispose carriers to a high risk of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through the assembly of multiple protein complexes involved in DNA repair, cell-cycle arrest, and transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613a82001de26e4f5af73828458714ad
https://pubmed.ncbi.nlm.nih.gov/24746700

BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability.

Autor: Savage KI; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Matchett KB; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Barros EM; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Cooper KM; Institute for Global Food Security, Queen's University Belfast, 30 Malone Rd, Belfast BT9 5BN, UK., Irwin GW; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Gorski JJ; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Orr KS; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Vohhodina J; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Kavanagh JN; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Madden AF; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Powell A; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK.; Institute for Global Food Security, Queen's University Belfast, 30 Malone Rd, Belfast BT9 5BN, UK., Manti L; Radiation Biophysics Laboratory, Department of Physics, University of Naples Federico II, Via Cinthia-80126 Naples, Italy., McDade SS; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Park BH; The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Prise KM; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., McIntosh SA; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Salto-Tellez M; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Richard DJ; Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, 4059, Brisbane, Australia., Elliott CT; Institute for Global Food Security, Queen's University Belfast, 30 Malone Rd, Belfast BT9 5BN, UK., Harkin DP; Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK.

Publikováno v: Cancer research [Cancer Res] 2014 May 15; Vol. 74 (10), pp. 2773-2784. Date of Electronic Publication: 2014 Mar 17.