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Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.

Autor: Pilo CA; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92037, USA., Baffi TR; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA., Kornev AP; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA., Kunkel MT; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA., Malfavon M; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA., Chen DH; Department of Neurology, University of Washington, Seattle, WA 98195, USA., Rossitto LA; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92037, USA., Chen DX; Department of Neurology, University of Washington, Seattle, WA 98195, USA., Huang LC; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA., Longman C; Queen Elizabeth University Hospital, Glasgow, Scotland G51 4TF, UK., Kannan N; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Raskind WH; Department of Medicine/Medical Genetics, University of Washington, Seattle, WA 98195, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA.; Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs, Seattle, WA 98108, USA., Gonzalez DJ; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA., Taylor SS; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA., Gorrie G; Queen Elizabeth University Hospital, Glasgow, Scotland G51 4TF, UK., Newton AC; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.

Publikováno v: Science signaling [Sci Signal] 2022 Sep 27; Vol. 15 (753), pp. eabk1147. Date of Electronic Publication: 2022 Sep 27.

Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective.

Autor: Wong C; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Stavrou M; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.; UK Dementia Research Institute, Chancellor's Building, The University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Elliott E; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.; UK Dementia Research Institute, Chancellor's Building, The University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Gregory JM; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.; UK Dementia Research Institute, Chancellor's Building, The University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Leigh N; Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9PX, UK., Pinto AA; Neurology Department, Wessex Neurosciences Centre, Southampton General Hospital, Southampton, SO16 6YD, UK., Williams TL; Department of Neurology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK., Chataway J; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London WC1B 5EH, UK.; National Institute for Health Research, University College London Hospitals, Biomedical Research Centre, London, W1T 7DN, UK.; MRC CTU at UCL, Institute of Clinical Trials and Methodology, University College London, London, WC1V 6LJ, UK., Swingler R; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Parmar MKB; MRC CTU at UCL, Institute of Clinical Trials and Methodology, University College London, London, WC1V 6LJ, UK., Stallard N; Statistics and Epidemiology, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK., Weir CJ; Edinburgh Clinical Trials Unit, Usher Institute, Level 2, NINE Edinburgh BioQuarter, 9 Little France Road, Edinburgh EH16 4UX, UK., Parker RA; Edinburgh Clinical Trials Unit, Usher Institute, Level 2, NINE Edinburgh BioQuarter, 9 Little France Road, Edinburgh EH16 4UX, UK., Chaouch A; Motor Neurone Disease Care Centre, Manchester Centre for Clinical Neurosciences, Salford, M6 8HD, UK., Hamdalla H; Motor Neurone Disease Care Centre, Manchester Centre for Clinical Neurosciences, Salford, M6 8HD, UK., Ealing J; Motor Neurone Disease Care Centre, Manchester Centre for Clinical Neurosciences, Salford, M6 8HD, UK., Gorrie G; Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Glasgow, G51 4TF, UK., Morrison I; Department of Neurology, NHS Tayside, Dundee, DD2 1UB, UK., Duncan C; Department of Neurology, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZN, UK., Connelly P; NHS Research Scotland Neuroprogressive Disorders and Dementia Network, Ninewells Hospital, Dundee, DD1 9SY, UK., Carod-Artal FJ; Department of Neurology, NHS Highland, Inverness, IV2 3UJ, UK., Davenport R; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Department of Clinical Neurosciences, NHS Lothian, Edinburgh, EH16 4SA, UK., Reitboeck PG; Atkinson Morley Regional Neurosciences Centre, St. George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK., Radunovic A; Barts MND Centre, Barts Health NHS Trust, London, E1 1FR, UK., Srinivasan V; Department of Neurology, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, UK., Preston J; Department of Neurology, NHS Ayrshire & Arran, KA12 8SS, UK., Mehta AR; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.; UK Dementia Research Institute, Chancellor's Building, The University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Leighton D; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Glasmacher S; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Beswick E; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Williamson J; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Stenson A; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Weaver C; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Newton J; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Lyle D; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Dakin R; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Macleod M; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK., Pal S; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Chandran S; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, FU303F, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.; UK Dementia Research Institute, Chancellor's Building, The University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.

Publikováno v: Brain communications [Brain Commun] 2021 Oct 23; Vol. 3 (4), pp. fcab242. Date of Electronic Publication: 2021 Oct 23 (Print Publication: 2021).

Abstracts of the 20 th Biennial Migraine Trust International Symposium, London UK, 5th to 8th September 2024.

Publikováno v: Cephalalgia. Dec2024, Vol. 44 Issue 12, p1-96. 96p.

Gastrostomy in patients with amyotrophic lateral sclerosis (ProGas): a prospective cohort study

Autor: McDermott, C.J., Shaw, P.J., Stavroulakis, T., Walters, S.J., Al-Chalabi, A., Chandran, S., Crawley, F., Dick, D., Donaghy, C., Eames, P., Fish, M., Gent, C., Gorrie, G., Hamdalla, H., Hanemann, C.O., Johnson, M., Majeed, T., Malaspina, A., Morrison, K., Orrell, R., Pinto, A., Radunovic, A., Roberts, M., Talbot, K., Turner, M.R., Williams, T., Young, C.

Background\ud \ud Gastrostomy feeding is commonly used to support patients with amyotrophic lateral sclerosis who develop severe dysphagia. Although recommended by both the American Academy of Neurology and the European Federation of Neurological Soc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::539297c6fb73ab57e14f0aa0441a3076