Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Goro Sashida"'
Autor:
Takuro Kameda, Kotaro Shide, Ayako Kamiunten, Yasunori Kogure, Daisuke Morishita, Junji Koya, Yuki Tahira, Keiichi Akizuki, Takako Yokomizo-Nakano, Sho Kubota, Kosuke Marutsuka, Masaaki Sekine, Tomonori Hidaka, Yoko Kubuki, Yuichi Kitai, Tadashi Matsuda, Akinori Yoda, Takayuki Ohshima, Midori Sugiyama, Goro Sashida, Keisuke Kataoka, Seishi Ogawa, Kazuya Shimoda
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The oncogenic ability of mutant CARD11 (E626K), one of most frequently mutated genes in adult T-cell leukemia and its cooperative effect with HBZ expression, using the CD4 promoter-driven HBZ transgenic mouse model, is investigated.
Externí odkaz:
https://doaj.org/article/d17a1c80cf93421a824fd4199e16edcb
Autor:
Yasutaka Hayashi, Susumu Goyama, XiaoXiao Liu, Moe Tamura, Shuhei Asada, Yosuke Tanaka, Tomofusa Fukuyama, Mark Wunderlich, Eric O’Brien, Benjamin Mizukawa, Satoshi Yamazaki, Akiko Matsumoto, Satoshi Yamasaki, Tatsuhiro Shibata, Koichi Matsuda, Goro Sashida, Hitoshi Takizawa, Toshio Kitamura
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
MDM2 is frequently overexpressed in acute myeloid leukaemia leading to p53 inactivation. Here, the authors are demonstrating that an inhibitor of p53-MDM2 interaction, DS-5272, induce in vivo tumour regression through immune response regulation.
Externí odkaz:
https://doaj.org/article/ac8963cff5ca454687e5a94c4c01ac79
Autor:
Sho Kubota, Kenji Tokunaga, Tomohiro Umezu, Takako Yokomizo-Nakano, Yuqi Sun, Motohiko Oshima, Kar Tong Tan, Henry Yang, Akinori Kanai, Eisaku Iwanaga, Norio Asou, Takahiro Maeda, Naomi Nakagata, Atsushi Iwama, Kazuma Ohyashiki, Motomi Osato, Goro Sashida
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Translocation of (6;8)(p21;q24), a recurrent abnormality of blastic plasmacytoid dendritic cell neoplasm, involves adjacent MYC and RUNX2 regions. Here, the authors show that the RUNX2 super-enhancer is hijacked to activate MYC in addition to RUNX2 e
Externí odkaz:
https://doaj.org/article/b55f6237adba4583b97db796afe3c64f
Autor:
Kazumasa Aoyama, Motohiko Oshima, Shuhei Koide, Emi Suzuki, Makiko Mochizuki-Kashio, Yuko Kato, Shiro Tara, Daisuke Shinoda, Nobuhiro Hiura, Yaeko Nakajima-Takagi, Goro Sashida, Atsushi Iwama
Publikováno v:
iScience, Vol 9, Iss , Pp 161-174 (2018)
Summary: Polycomb repressive complex (PRC) 2 represses transcription through histone H3K27 trimethylation (H3K27me3). We previously reported that the hematopoietic-cell-specific deletion of Ezh2, encoding a PRC2 enzyme, induced myelodysplastic syndro
Externí odkaz:
https://doaj.org/article/3b90d27dcc1247fc9e8e1ebcd0d352b0
Autor:
Tadahito Yasuda, Mayu Koiwa, Atsuko Yonemura, Keisuke Miyake, Ryusho Kariya, Sho Kubota, Takako Yokomizo-Nakano, Noriko Yasuda-Yoshihara, Tomoyuki Uchihara, Rumi Itoyama, Luke Bu, Lingfeng Fu, Kota Arima, Daisuke Izumi, Shiro Iwagami, Kojiro Eto, Masaaki Iwatsuki, Yoshifumi Baba, Naoya Yoshida, Hiroto Ohguchi, Seiji Okada, Keisuke Matsusaki, Goro Sashida, Akiko Takahashi, Patrick Tan, Hideo Baba, Takatsugu Ishimoto
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108779- (2021)
Summary: In the tumor microenvironment, senescent non-malignant cells, including cancer-associated fibroblasts (CAFs), exhibit a secretory profile under stress conditions; this senescence-associated secretory phenotype (SASP) leads to cancer progress
Externí odkaz:
https://doaj.org/article/3ca48152ebfc477bbbd863180a470749
Autor:
Peter Balogh, Emmalee R. Adelman, John V. Pluvinage, Brian J. Capaldo, Katie C. Freeman, Sandeep Singh, Kamaleldin E. Elagib, Yukio Nakamura, Ryo Kurita, Goro Sashida, Eli R. Zunder, Hui Li, Alejandro A. Gru, Elizabeth A. Price, Stanley L. Schrier, Irving L. Weissman, Maria E. Figueroa, Wendy W. Pang, Adam N. Goldfarb
Publikováno v:
Haematologica, Vol 105, Iss 4 (2020)
Healthy bone marrow progenitors yield a co-ordinated balance of hematopoietic lineages. This balance shifts with aging toward enhanced granulopoiesis with diminished erythropoiesis and lymphopoiesis, changes which likely contribute to the development
Externí odkaz:
https://doaj.org/article/140cf8159011466eac9107c51977f0f3
Publikováno v:
Cancers, Vol 13, Iss 4, p 791 (2021)
Cholangiocarcinoma (CCA) is the second most common type of hepatic cancer. In east and southeast Asia, intrahepatic CCA is caused predominantly by infection of Opisthorchis viverrini and Clonorchis sinensis, two species of parasitic liver flukes. In
Externí odkaz:
https://doaj.org/article/6fa6817248a44dbb9732101b2605e000
Autor:
Takuro Kameda, Kotaro Shide, Takumi Yamaji, Ayako Kamiunten, Masaaki Sekine, Tomonori Hidaka, Yoko Kubuki, Goro Sashida, Kazumasa Aoyama, Makoto Yoshimitsu, Hiroo Abe, Tadashi Miike, Hisayoshi Iwakiri, Yoshihiro Tahara, Shojiro Yamamoto, Satoru Hasuike, Kenji Nagata, Atsushi Iwama, Akira Kitanaka, Kazuya Shimoda
Publikováno v:
Genomics Data, Vol 4, Iss C, Pp 102-108 (2015)
Myeloproliferative neoplasms (MPNs) are clinically characterized by the chronic overproduction of differentiated peripheral blood cells and the gradual expansion of malignant intramedullary/extramedullary hematopoiesis. In MPNs mutations in JAK2 MPL
Externí odkaz:
https://doaj.org/article/2d4740546cb944d5b9d47c8552d81e9f
Autor:
Sho Kubota, Kenji Tokunaga, Tomohiro Umezu, Takako Yokomizo-Nakano, Yuqi Sun, Motohiko Oshima, Kar Tong Tan, Henry Yang, Akinori Kanai, Eisaku Iwanaga, Norio Asou, Takahiro Maeda, Naomi Nakagata, Atsushi Iwama, Kazuma Ohyashiki, Motomi Osato, Goro Sashida
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/a9f5b6ded55344b394d22695b04a566d
Autor:
Masato Kanda, Toshio Nagai, Toshinao Takahashi, Mei Lan Liu, Naomichi Kondou, Atsuhiko T Naito, Hiroshi Akazawa, Goro Sashida, Atsushi Iwama, Issei Komuro, Yoshio Kobayashi
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156562 (2016)
Cardiac stem cells or precursor cells regenerate cardiomyocytes; however, the mechanism underlying this effect remains unclear. We generated CreLacZ mice in which more than 99.9% of the cardiomyocytes in the left ventricular field were positive for 5
Externí odkaz:
https://doaj.org/article/951d8a3e902f48588e1d9e7b96dca34d