CD4 mAbs prevent progression of alloactivated CD4+ T cells into the S phase of the cell cycle without interfering with early activation signals

Autor: Fournel, S, Vincent, C, Assossou, O, Gorman, SD, Robinet, E, Phillips, JM, Flacher, M, Cordier, G, Waldmann, H, Revillard, JP

Knowing that several CD4 mAbs may delay allograft rejection in the absence of circulating CD4+ lymphocyte depletion in vivo, we investigated the mechanisms whereby CD4 mAbs can interfere with the development of alloreactive T cells in the mixed lymph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8829cca7ee9ff47aa75fa209eec95321
https://ora.ox.ac.uk/objects/uuid:905c94db-7922-4c59-933a-6eda95d97c94

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Defining the condensate landscape of fusion oncoproteins.

Autor: Tripathi S; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Shirnekhi HK; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Gorman SD; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Arrakis Therapeutics, 830 Winter St, Waltham, MA, 02451, USA., Chandra B; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Baggett DW; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Park CG; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Somjee R; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Rhodes College, Memphis, TN, USA.; Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA., Lang B; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center of Excellence for Data-Driven Discovery, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Hosseini SMH; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center of Excellence for Data-Driven Discovery, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Pioso BJ; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Li Y; Livestrong Cancer Institutes, Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, 78712, USA., Iacobucci I; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Gao Q; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Edmonson MN; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Rice SV; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Zhou X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Bollinger J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Mitrea DM; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Dewpoint Therapeutics, 451 D Street, Suite 104, Boston, MA, 02210, USA., White MR; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; IDEXX Laboratories, Inc., One IDEXX Drive, Westbrook, ME, 04092, USA., McGrail DJ; Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Jarosz DF; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA., Yi SS; Livestrong Cancer Institutes, Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, 78712, USA.; Department of Biomedical Engineering, and Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX, USA., Babu MM; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center of Excellence for Data-Driven Discovery, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Sahni N; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, USA., Kriwacki RW; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. richard.kriwacki@stjude.org.; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN, USA. richard.kriwacki@stjude.org.

Publikováno v: Nature communications [Nat Commun] 2023 Sep 28; Vol. 14 (1), pp. 6008. Date of Electronic Publication: 2023 Sep 28.