Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gorm Yoder"'
Autor:
William R Proctor, Sherry Ralston, Szczepan W Baran, Gorm Yoder, Brian R. Berridge, Kristin Fabre, Yvonne Will, Terry R. Van Vleet
Publikováno v:
Lab on a Chip. 20:1049-1057
Safety related drug failures continue to be a challenge for pharmaceutical companies despite the numerous complex and lengthy in vitro assays and in vivo studies that make up the typical safety screening funnel. A lack of complete translation of anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076b0fe9f6741c5106bc32ac5fb4e1c2
https://doi.org/10.1039/c9lc01168d
https://doi.org/10.1039/c9lc01168d
Autor:
Szczepan W, Baran, Paul C, Brown, Andreas R, Baudy, Suzanne C, Fitzpatrick, Christopher, Frantz, Aaron, Fullerton, Jinping, Gan, Rhiannon N, Hardwick, Kathleen M, Hillgren, Anna K, Kopec, Jennifer L, Liras, Donna L, Mendrick, Ryan, Nagao, William R, Proctor, Diane, Ramsden, Alexandre J S, Ribeiro, David, Stresser, Kyung E, Sung, Radhakrishna, Sura, Kazuhiro, Tetsuka, Lindsay, Tomlinson, Terry, Van Vleet, Matthew P, Wagoner, Qin, Wang, Sevim Yildiz, Arslan, Gorm, Yoder, Jason E, Ekert
Publikováno v:
ALTEX.
Complex in vitro models (CIVM) offer the potential to improve pharmaceutical clinical drug attrition due to safety and/ or efficacy concerns. For this technology to have an impact, the establishment of robust characterization and qualification plan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991b82190055f9a932fb29fb1692bafd
https://doi.org/10.14573/altex.2112203
https://doi.org/10.14573/altex.2112203
Autor:
Gorm Yoder, Garrett R Ainslie, Andrew J. Thorley, Anne M. Ryan, Myrtle Davis, Linda A. Lieberman, Lorna Ewart, David J. Rowlands
Publikováno v:
Lab on a Chip. 19:3152-3161
The lung is a complex organ; it is both the initial barrier for inhaled agents and the site of metabolism and therapeutic effect for a subset of systemically administered drugs. Comprised of more than 40 cell types that are responsible for various im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894aaf9b62a0b858baf6d30f21581397
https://doi.org/10.1039/c9lc00492k
https://doi.org/10.1039/c9lc00492k
Publikováno v:
Biochemistry. 36:15123-15133
Vibrational circular dichroism (VCD) and Fourier transform IR (FTIR) were measured for a series of short alanine-based peptides having the general formula Ac-(AAKAA)n-GY-NH2 (n = 1-4) from 5 to 50 degrees C in D2O and at room temperature in both TFE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b5696f39c1a649adb10d9248f836a8
https://doi.org/10.1021/bi971460g
https://doi.org/10.1021/bi971460g
Publikováno v:
Biopolymers. 36:623-631
Vibrational CD (VCD) spectra of a series of blocked linear, alternating D- and L-proline containing oligopeptides, dissolved in D2O and in CDCl3, are reported. For the Boc-LDL-Pro3 to Boc-DLDLDLDL-Pro8 oligomers, the VCD spectra in the amide I band i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de297869205589d3c9530bc9b2068401
https://doi.org/10.1002/bip.360360508
https://doi.org/10.1002/bip.360360508
Autor:
Johan Kamphuis, Timothy A. Keiderling, Marco Crisma, Claudio Toniolo, Fernando Formaggio, Gorm Yoder
Publikováno v:
Tetrahedron: Asymmetry. 6:687-690
Vibrational circular dichroism spectra for three homo-oligopeptides, p -BrBz-[D-(αMe)Phe] 4,5 -O t Bu and p -BrBz-(D-Iva) 5 -O t Bu, are presented and interpreted to show that the C α -methylated α-amino acids (αMe)Phe and Iva of the same optical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e39782630c172d786bc0c3d4c6ad346
https://doi.org/10.1016/0957-4166(95)00062-t
https://doi.org/10.1016/0957-4166(95)00062-t
Autor:
Alessandra Polese, Claudio Toniolo, Timothy A. Keiderling, Johan Kamphuis, Quirinus B. Broxterman, Gorm Yoder, Fernando Formaggio, Marco Crisma
Publikováno v:
American Peptide Symposia ISBN: 0792351606
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b085bec4a9a5aef553fe4f44faed4b1
https://doi.org/10.1007/0-306-46862-x_159
https://doi.org/10.1007/0-306-46862-x_159
Publikováno v:
Bioorganicmedicinal chemistry. 7(1)
Vibrational circular dichroism (VCD) has been shown to be a useful technique for characterization of the qualitative secondary structure type for linear polypeptides and oligopeptides. A brief review of characteristic spectral responses and applicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3af136e975de2fbacb321b38f74321
https://pubmed.ncbi.nlm.nih.gov/10199663
https://pubmed.ncbi.nlm.nih.gov/10199663
Autor:
Timothy A. Keiderling, Gorm Yoder
Publikováno v:
Spectroscopy of Biological Molecules: Modern Trends ISBN: 9789401063692
Understanding of the protein folding process has become a major focus of current biophysical research. One of the most important motifs for protein folds is the α-helix which can be difficult to model due to its relative instability in aqueous solut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76bb341688e9cdc48b3f7d43f9d237c2
https://doi.org/10.1007/978-94-011-5622-6_12
https://doi.org/10.1007/978-94-011-5622-6_12
Autor:
Claudio Toniolo, R. A. G. D. Silva, Alessandra Polese, Gorm Yoder, Quirinus B. Broxterman, Timothy A. Keiderling, Fernando Formaggio, Marco Crisma, Johan Kamphuis
Vibrational and electronic circular dichroism (VCD and ECD) and Fourier transform infrared (FTIR) spectra of the homo-oligopeptide series Z-[l-(αMe)Val]n-OtBu (n = 3−8) and selected Ac-[l-(αMe)Val]n-OtBu oligomers (n = 4, 6, 8) are presented. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7093382bdea294a19feb2ab54b531f
http://hdl.handle.net/11577/2523542
http://hdl.handle.net/11577/2523542