Výsledky vyhledávání - "Gorkem Kismali"

Akademický článek

Anticancer effects of a newly-synthesized benzoxazole-derived 5-amino-2- [P-bromophenyl]-benzoxazole in breast cancer cell lines

Autor: Funda Kosova, Ozlem Temiz Arpaci, Ibrahim Tuglu, Ercument Olmez, Feyzan Ozdal Kurt, Gorkem Kismali, Zeki Ari, Mustafa Arisoy

Publikováno v: Medicine Science, Vol 11, Iss 2, Pp 825-30 (2022)

We investigated the anticancer potential of 5-amino-2-[p-bromophenyl]-benzoxazole [BB] which is a new benzoxazole derivative in different breast cancer cell lines. BB was applied to estrogen receptor positive [ER+] MCF-7 and receptor negative [ER-] M

Externí odkaz: https://doaj.org/article/fda1b39683c84a23bb31167e52bd5e79

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Akademický článek

Pirtobrutinib inhibits wild-type and mutant Bruton’s tyrosine kinase-mediated signaling in chronic lymphocytic leukemia

Autor: Burcu Aslan, Gorkem Kismali, Lakesla R. Iles, Ganiraju C. Manyam, Mary L. Ayres, Lisa S. Chen, Mihai Gagea, Maria Teresa Sabrina Bertilaccio, William G. Wierda, Varsha Gandhi

Publikováno v: Blood Cancer Journal, Vol 12, Iss 5, Pp 1-12 (2022)

Abstract Pirtobrutinib (LOXO-305), a reversible inhibitor of Bruton’s tyrosine kinase (BTK), was designed as an alternative strategy to treat ibrutinib-resistant disease that develops due to C481 kinase domain mutations. The clinical activity of pi

Externí odkaz: https://doaj.org/article/8888c6f8f7de463288f684d22b1c67b9

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Akademický článek

Piperlongumine inhibits cell growth and enhances TRAIL-induced apoptosis in prostate cancer cells

Autor: Gorkem Kismali, Ahmet Ceylan, Ogunc Meral, Merve Alpay, Funda Kosova, Dilek Ulker Cakir, Begum Yurdakok-Dikmen, Neslihan Tascene, Tevhide Sel

Publikováno v: Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 5, Pp 216-223 (2020)

Objective: To investigate whether piperlongumine can sensitize prostate cancer cells to tumor necrosis factor-related apoptosis- inducing ligand (TRAIL) and trigger apoptosis in prostate cells. Methods: Human prostate cancer cell lines PC3, LNCaP, an

Externí odkaz: https://doaj.org/article/599d2cc38da94c908bdab4ff66c07b86

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