Dysfunction of Endothelial Progenitor Cells from Smokers and Chronic Obstructive Pulmonary Disease Patients Due to Increased DNA Damage and Senescence

Autor: Paschalaki, KE, Starke, RD, Hu, Y, Mercado, N, Margariti, A, Gorgoulis, VG, Randi, AM, Barnes, PJ

Publikováno v: Paschalaki, K E, Starke, R D, Hu, Y, Mercado, N, Margariti, A, Gorgoulis, V G, Randi, A M & Barnes, P J 2013, ' Dysfunction of Endothelial Progenitor Cells from Smokers and Chronic Obstructive Pulmonary Disease Patients Due to Increased DNA Damage and Senescence ', Stem Cells, vol. 31, no. 12, pp. 2813-2826 . https://doi.org/10.1002/stem.1488

Cardiovascular disease (CVD) is a major cause of death in smokers, particularly in those with chronic obstructive pulmonary disease (COPD). Circulating endothelial progenitor cells (EPC) are required for endothelial homeostasis, and their dysfunction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3e6b8571848a3834a41bfef00b20c764
https://pure.qub.ac.uk/en/publications/dysfunction-of-endothelial-progenitor-cells-from-smokers-and-chronic-obstructive-pulmonary-disease-patients-due-to-increased-dna-damage-and-senescence(ddaf6308-a739-4f33-b1d8-a67dfc5e884a).html

Relationship between iNOS expression and aortic cell proliferation and apoptosis in an elastase-induced model of aorta aneurysm and the effect of 1400 W administration

Autor: Sigala, F Papalambros, E Kotsinas, A Andreadou, I and Sigalas, P Kremastinos, D Bastounis, E Gorgoulis, VG

Background. In the present study, we employed an elastase infusion-dependent abdominal aortic aneurysm (AAA) model to examine inducible nitric oxide synthase (iNOS) expression in relation to cellular proliferation and apoptosis in this pathologic con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::f5b726b16cbd24c05cb2439ae2b73b5b
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3093832

Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas - Synergistic effect with mutant p53 on tumor growth and chromosomal instability - Evidence of E2F-1 transcriptional control over hCdt1

Autor: Karakaidos, P Taraviras, S Vassiliou, LV Zacharatos, P and Kastrinakis, NG Kougiou, D Kouloukoussa, M Nishitani, H and Papavassiliou, AG Lygerou, Z Gorgoulis, VG

Replication licensing ensures once per cell cycle replication and is essential for genome stability. Overexpression of two key licensing factors, Cdc6 and Cdt1, leads to overreplication and chromosomal instability (CIN) in lower eukaryotes and recent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::56329db1edc3e88fe2705f8bb4c14151
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3092189

Overexpression of activating transcription factor-2 is required for tumor growth and progression in mouse skin tumors

Autor: Papassava, P Gorgoulis, VG Papaevangeliou, D Vlahopoulos, S and van Dam, H Zoumpourlis, V

Activating transcription factor (ATF)-2 is a member of the ATF/cyclic AMP-responsive element binding protein family of transcription factors. It has been shown, in vitro, to possess growth factor-independent proliferation and transformation capacity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::eaefc005ad422f33c8945626bf4e2860
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3092590

Expression of mos in ependymal gliomas

Autor: Athanasiou, A Perunovic, B Quilty, RD Gorgoulis, VG and Kittas, C Love, S

The c-mos gene and its protein product mos, components of the mitogen-activated protein kinase transduction pathway, are known to be involved in the control of meiosis and mitosis. Apart from our previous studies on lung carcinomas and astrocytic gli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::20cbf8b74a283d6314d9e752ff68c303
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3084516