A screen for cell envelope stress uncovers an inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli

Autor: Rachwalski, Kenneth, Madden, Sean J., Ritchie, Nicole, French, Shawn, Bhando, Timsy, Girgis-Gabardo, Adele, Tu, Megan, Gordzevich, Rodion, Ives, Rowan, Guo, Amelia B.Y., Johnson, Jarrod W., Xu, Yiming, Kapadia, Sharookh B., Magolan, Jakob, Brown, Eric D.

Publikováno v: In iScience 18 October 2024 27(10)

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CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database.

Autor: Alcock BP; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Huynh W; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Chalil R; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Smith KW; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Raphenya AR; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Wlodarski MA; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Edalatmand A; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Petkau A; Department of Computer Science, University of Manitoba, Winnipeg, Manitoba, Canada.; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Syed SA; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Tsang KK; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Baker SJC; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Dave M; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., McCarthy MC; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Mukiri KM; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Nasir JA; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Golbon B; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Imtiaz H; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Jiang X; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Kaur K; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Kwong M; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Liang ZC; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Niu KC; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Shan P; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Yang JYJ; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Gray KL; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada., Hoad GR; Research Computing Group, Simon Fraser University, Burnaby, British Columbia, Canada., Jia B; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada., Bhando T; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Carfrae LA; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Farha MA; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., French S; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Gordzevich R; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Rachwalski K; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Tu MM; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Bordeleau E; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Dooley D; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Griffiths E; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Zubyk HL; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Brown ED; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Maguire F; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.; Institute for Comparative Genomics, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Community Health & Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada., Beiko RG; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.; Institute for Comparative Genomics, Dalhousie University, Halifax, Nova Scotia, Canada., Hsiao WWL; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Brinkman FSL; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada., Van Domselaar G; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada., McArthur AG; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2023 Jan 06; Vol. 51 (D1), pp. D690-D699.