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Association of Occupational Dysfunction and Hospital Admissions With Different Polygenic Profiles in Bipolar Disorder.

Autor: Jonsson L; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Hörbeck E; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Primerano A; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Song J; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Karlsson R; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Smedler E; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Gordon-Smith K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Jones L; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Craddock N; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Jones I; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Sullivan PF; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Pålsson E; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Di Florio A; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Sparding T; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan)., Landén M; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Jonsson, Hörbeck, Smedler, Pålsson, Sparding, Landén); National Centre for Mental Health, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Primerano, Craddock, I. Jones, Di Florio); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm (Song, Karlsson, Sullivan, Landén); Mental Health Center and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China (Song); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Gordon-Smith, L. Jones); Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill (Sullivan).

Publikováno v: The American journal of psychiatry [Am J Psychiatry] 2024 Jul 01; Vol. 181 (7), pp. 620-629. Date of Electronic Publication: 2024 Jun 11.