Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Gordon S. Duncan"'
Autor:
Zhenyue Hao, Yi Sheng, Gordon S. Duncan, Wanda Y. Li, Carmen Dominguez, Jennifer Sylvester, Yu-Wen Su, Gloria H.Y. Lin, Bryan E. Snow, Dirk Brenner, Annick You-Ten, Jillian Haight, Satoshi Inoue, Andrew Wakeham, Alisha Elford, Sara Hamilton, Yi Liang, Juan C. Zúñiga-Pflücker, Housheng Hansen He, Pamela S. Ohashi, Tak W. Mak
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The E3 ligase Mule has been previously reported to be essential for B cell development and function by modulating p53 ubiquitination and degradation. Here Haoet al. identify KLF4 as a novel ubiquitination target of Mule and show it controls T cell pr
Externí odkaz:
https://doaj.org/article/e6eb6c78746d4519b89d713cb4a6a1dc
Autor:
Robert Nechanitzky, Duygu Nechanitzky, Parameswaran Ramachandran, Gordon S. Duncan, Chunxing Zheng, Christoph Göbl, Kyle T. Gill, Jillian Haight, Andrew C. Wakeham, Bryan E. Snow, Vivian Bradaschia-Correa, Milan Ganguly, Zhibin Lu, Mary E. Saunders, Richard A. Flavell, Tak W. Mak
Publikováno v:
Cell Death & Differentiation. 30:407-416
Autor:
Julie Leca, Franҫois Lemonnier, Cem Meydan, Jonathan Foox, Samah El Ghamrasni, Diana-Laure Mboumba, Gordon S. Duncan, Jerome Fortin, Takashi Sakamoto, Chantal Tobin, Kelsey Hodgson, Jillian Haight, Logan K. Smith, Andrew J. Elia, Daniel Butler, Thorsten Berger, Laurence de Leval, Christopher E. Mason, Ari Melnick, Philippe Gaulard, Tak W. Mak
Publikováno v:
Cancer cell, vol. 41, no. 2, pp. 323-339.e10
Angioimmunoblastic T cell lymphoma (AITL) is a peripheral T cell lymphoma that originates from T follicular helper (Tfh) cells and exhibits a prominent tumor microenvironment (TME). IDH2 and TET2 mutations co-occur frequently in AITL, but their contr
Autor:
Melanie Grusdat, Ying Chen, Dennis Das Gupta, Tak W. Mak, Rashi Halder, Sophie Farinelle, Christian Jäger, Johannes Meiser, Luana Guerra, Lynn Bonetti, Gordon S. Duncan, Anouk Ewen, Lisa Schlicker, Paul Wilmes, Karsten Hiller, Jillian Haight, Myriam P. Merz, Yannic Nonnenmacher, Michael Lohoff, Rabia Taskesen, Vasilis Vasiliou, Markus Ollert, Davide G. Franchina, Carole Binsfeld, Isaac S. Harris, Christiane B. Knobbe-Thomsen, Oliver Hunewald, Henry Kurniawan, Dirk Brenner, Jonathan D. Turner, Leticia Soriano Baguet, Catherine Dostert
Publikováno v:
Cell Metab
936.e7
Cell metabolism
United States
Kurniawan, H, Franchina, D G, Guerra, L, Bonetti, L, Baguet, L S, Grusdat, M, Schlicker, L, Hunewald, O, Dostert, C, Merz, M P, Binsfeld, C, Duncan, G S, Farinelle, S, Nonnenmacher, Y, Haight, J, Das Gupta, D, Ewen, A, Taskesen, R, Halder, R, Chen, Y, Jäger, C, Ollert, M, Wilmes, P, Vasiliou, V, Harris, I S, Knobbe-Thomsen, C B, Turner, J D, Mak, T W, Lohoff, M, Meiser, J, Hiller, K & Brenner, D 2020, ' Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function ', Cell Metabolism, vol. 31, no. 5, pp. 920-936.e7 . https://doi.org/10.1016/j.cmet.2020.03.004
936.e7
Cell metabolism
United States
Kurniawan, H, Franchina, D G, Guerra, L, Bonetti, L, Baguet, L S, Grusdat, M, Schlicker, L, Hunewald, O, Dostert, C, Merz, M P, Binsfeld, C, Duncan, G S, Farinelle, S, Nonnenmacher, Y, Haight, J, Das Gupta, D, Ewen, A, Taskesen, R, Halder, R, Chen, Y, Jäger, C, Ollert, M, Wilmes, P, Vasiliou, V, Harris, I S, Knobbe-Thomsen, C B, Turner, J D, Mak, T W, Lohoff, M, Meiser, J, Hiller, K & Brenner, D 2020, ' Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function ', Cell Metabolism, vol. 31, no. 5, pp. 920-936.e7 . https://doi.org/10.1016/j.cmet.2020.03.004
Regulatory T cells (Tregs) maintain immune homeostasis and prevent autoimmunity. Serine stimulates glutathione (GSH) synthesis and feeds into the one-carbon metabolic network (1CMet) essential for effector T cell (Teff) responses. However, serine's f
Autor:
Mariela Sivina, William G. Wierda, Andreas Rosenwald, Michael J. Keating, Ekaterina Kim, Elena Hartmann, Alessandra Ferrajoli, Alicia Vaca, Jan A. Burger, Gordon S. Duncan, Takashi Sakamoto, Tak W. Mak
Publikováno v:
Blood. 134:5448-5448
Background: Toso, the FcR receptor (FcmR) for IgM, is a type I transmembrane protein belonging to the immunoglobulin gene superfamily. Toso is expressed in lymphocytes, and plays an important role in B cell development and survival. In normal B cells
Autor:
Dave Cescon, Dirk Brenner, Evan F. Lind, Annick You-Ten, Andrew J. Elia, Momoe Itsumi, Philipp A. Lang, Masato Sasaki, Andrew Wakeham, Isaac S. Harris, Alisha R. Elford, Gordon S. Duncan, Pamela S. Ohashi, Tak W. Mak, Rob A. Cairns, Wanda Y. Li, Satoshi Inoue, Iok In Christine Chio, Jillian Haight, Kiichi Murakami, J Ye, Samia Afzal, Kazuo Yamamoto, Bryan E. Snow
Publikováno v:
Cell Death and Differentiation
Isocitrate dehydrogenase-1 (Idh1) is an important metabolic enzyme that produces NADPH by converting isocitrate to α-ketoglutarate. Idh1 is known to reduce reactive oxygen species (ROS) induced in cells by treatment with lipopolysaccharide (LPS) in
Autor:
Tak W. Mak, Zhenyue Hao, Sara R. Hamilton, Juan Carlos Zúñiga-Pflücker, Jillian Haight, Satoshi Inoue, Wanda Y. Li, Gloria H. Y. Lin, Gordon S. Duncan, Yi Sheng, Dirk Brenner, Alisha R. Elford, Yi Liang, Yu-Wen Su, Jennifer Sylvester, Annick You-Ten, Pamela S. Ohashi, Housheng Hansen He, Andrew Wakeham, Bryan E. Snow, Carmen Dominguez
Publikováno v:
Hao, Z, Sheng, Y, Duncan, G S, Li, W Y, Dominguez, C, Sylvester, J, Su, Y W, Lin, G H Y, Snow, B E, Brenner, D, You-Ten, A, Haight, J, Inoue, S, Wakeham, A, Elford, A, Hamilton, S, Liang, Y, Zúñiga-Pflücker, J C, He, H H, Ohashi, P S & Mak, T W 2017, ' K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression ', Nature Communications, vol. 8, 14003 . https://doi.org/10.1038/ncomms14003
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
T-cell proliferation is regulated by ubiquitination but the underlying molecular mechanism remains obscure. Here we report that Lys-48-linked ubiquitination of the transcription factor KLF4 mediated by the E3 ligase Mule promotes T-cell entry into S
Autor:
Anne Brüstle, Thomas Mock, Michael W. Tusche, Andrew J. Elia, Dirk Brenner, Gordon S. Duncan, Christiane B. Knobbe, Peter H. Krammer, Mark R. Bray, Tak W. Mak
Publikováno v:
Proceedings of the National Academy of Sciences. 109:21034-21039
The endogenous metabolite of estradiol, 2-Methoxyestradiol (2ME2), is an antimitotic and antiangiogenic cancer drug candidate that also exhibits disease-modifying activity in animal models of rheumatoid arthritis (RA). We found that 2ME2 dramatically
Autor:
Simon Preston, Yongkai Ow, Jesse G. Toe, Amy E. Lin, Hamish W Scott, Andrew Wakeham, Tak W. Mak, James P Cooney, Gregor Ebert, Jennifer Silvester, Raymond H. Kim, Samuel D. Saibil, Pamela S. Ohashi, Annick You-Ten, Arda Shahinian, Marc Pellegrini, Masato Sasaki, Dilan Dissanayake, Gordon S. Duncan
Publikováno v:
Nature Immunology. 14:27-33
The E3 ligase ARIH2 has an unusual structure and mechanism of elongating ubiquitin chains. To understand its physiological role, we generated gene-targeted mice deficient in ARIH2. ARIH2 deficiency resulted in the embryonic death of C57BL/6 mice. On
Autor:
Karsten Hiller, Anne Brüstle, Momoe Itsumi, Vasilis Vasiliou, Isaac S. Harris, Dirk Brenner, Tak W. Mak, Christian Jäger, Carsten Bindslev-Jensen, Maureen A. Cox, Catherine Dostert, Carole Binsfeld, Ying Chen, Philipp A. Lang, Michael Lohoff, Bärbel Camara, Yannic Nonnenmacher, Olaf Pinkenburg, Chiara Gorrini, Zhenyue Hao, Melanie Grusdat, Markus Ollert, Gordon S. Duncan
Publikováno v:
Mak, T W, Grusdat, M, Duncan, G S, Dostert, C, Nonnenmacher, Y, Cox, M, Binsfeld, C, Hao, Z, Brüstle, A, Itsumi, M, Jäger, C, Chen, Y, Pinkenburg, O, Camara, B, Ollert, M, Bindslev-Jensen, C, Vasiliou, V, Gorrini, C, Lang, P A, Lohoff, M, Harris, I S, Hiller, K & Brenner, D 2017, ' Glutathione Primes T Cell Metabolism for Inflammation ', Immunity, vol. 46, no. 4, pp. 675-689 . https://doi.org/10.1016/j.immuni.2017.03.019
Activated T cells produce reactive oxygen species (ROS), which trigger the antioxidative glutathione (GSH) response necessary to buffer rising ROS and prevent cellular damage. We report that GSH is essential for T cell effector functions through its