Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gordon R. Perkins"'
Publikováno v:
Current Biology. 11:1439-1443
Cells respond to stresses such as osmotic shock and heat shock by activating stress-activated protein kinases (SAPKs), including c-Jun N-terminal kinase (JNK) [1]. Activation of JNK requires phosphorylation of threonine and tyrosine residues in the T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee918e10d424e7c993e32b83248e2cc9
https://doi.org/10.1016/s0960-9822(01)00426-2
https://doi.org/10.1016/s0960-9822(01)00426-2
Publikováno v:
Current Biology. 10(5):231-240
Background: Cdc28p, the major cyclin-dependent kinase in budding yeast, prevents re-replication within each cell cycle by preventing the reassembly of Cdc6p-dependent pre-replicative complexes (pre-RCs) once origins have fired. Cdc6p is a rapidly deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86a92b526ff139db192a971df83a7b1
Autor:
Chantal Desdouets, John F.X. Diffley, Corrado Santocanale, Paolo Plevani, Lucy S. Drury, Gordon R. Perkins, Marco Foiani
Publikováno v:
The EMBO Journal. 17:4139-4146
Eukaryotic DNA replication is limited to once per cell cycle because cyclin-dependent kinases (cdks), which are required to fire origins, also prevent re-replication. Components of the replication apparatus, therefore, are 'reset' by cdk inactivation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80930695fc02a1d7a1faae801219d3e3
https://doi.org/10.1093/emboj/17.14.4139
https://doi.org/10.1093/emboj/17.14.4139
Autor:
Gordon R. Perkins, John F.X. Diffley
Publikováno v:
Molecular Cell. 2:23-32
Expression of the Cdc6 protein (Cdc6p) is essential for formation of prereplicative complexes at budding yeast replication origins. Analysis of mutations in the conserved nucleoside triphosphate (NTP)-binding site of Cdc6p described here suggests tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7740e2afa9b4d70aba2900b208b3cef7
https://doi.org/10.1016/s1097-2765(00)80110-0
https://doi.org/10.1016/s1097-2765(00)80110-0
Publikováno v:
The EMBO Journal. 16:5966-5976
The budding yeast Cdc6 protein (Cdc6p) is essential for formation of pre-replicative complexes (pre-RCs) at origins of DNA replication. Regulation of pre-RC assembly plays a key role in making initiation of DNA synthesis dependent upon passage throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66ef3b42a2c8e767bb2945f201907b7
https://doi.org/10.1093/emboj/16.19.5966
https://doi.org/10.1093/emboj/16.19.5966
Publikováno v:
Blood. 87:3669-3675
Expression of a dominant interfering mutant of MAP kinase kinase (MAPKK) inhibits interleukin-3 (IL-3) activation of MAP kinase in the murine bone marrow-derived cell line BAF3. This results in an increase in the level of IL-3 required to stimulate c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2d611910083b0481de51781e8dac3c2
https://doi.org/10.1182/blood.v87.9.3669.bloodjournal8793669
https://doi.org/10.1182/blood.v87.9.3669.bloodjournal8793669
Autor:
Abelardo López-Rivas, Gemma Rodríguez-Tarduchy, Maria Angela Nieto, Gordon R. Perkins, Mary Collins
Publikováno v:
BioEssays. 16:133-138
Apoptosis is now widely recognized as a common form of cell death and represents a mechanism of cell clearance in many physiological situations where deletion of cells is required. Peptide growth factors, initially characterised as stimulators of cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db4027bdd6bc711a3fb80aece3f8be88
https://doi.org/10.1002/bies.950160210
https://doi.org/10.1002/bies.950160210
Publikováno v:
International Immunology. 5:541-549
This report addresses the role of individual IL-2 binding proteins of the IL-2 receptor in the stimulation of cell proliferation by IL-2. Murine IL-3-dependent cell lines were established which expressed the human p75 IL-2-binding protein, in the abs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e3eea1be7249293368cb64297a8c7b
https://doi.org/10.1093/intimm/5.5.541
https://doi.org/10.1093/intimm/5.5.541
Publikováno v:
The Journal of biological chemistry. 278(12)
The c-Jun N-terminal kinase (JNK) group of mitogen-activated protein kinases (MAPKs) are activated by pleiotropic signals including environmental stresses, growth factors, and hormones. A subset of JNK can bind to distinct scaffold proteins that also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972c70b22323e88637290fe2c630b1b7
https://pubmed.ncbi.nlm.nih.gov/12524447
https://pubmed.ncbi.nlm.nih.gov/12524447
Publikováno v:
The EMBO journal. 20(17)
The Cdc6 DNA replication initiation factor is targeted for ubiquitin-mediated proteolysis by the E3 ubiquitin ligase SCF(CDC4) from the end of G1phase until mitosis in the budding yeast Saccharomyces cerevisiae. Here we describe a dominant-negative C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a32b691d54ab758977bafa5d77ba31
https://pubmed.ncbi.nlm.nih.gov/11532947
https://pubmed.ncbi.nlm.nih.gov/11532947