Zobrazeno 1 - 10
of 398
pro vyhledávání: '"Gordon R, Bernard"'
Autor:
Meghan Morrison Joly, Terri L. Edwards, Rebecca N. Jerome, Alex Mainor, Gordon R. Bernard, Jill M. Pulley
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
When seriously ill patients have exhausted all treatment options available as part of usual care, the use of investigational agents may be warranted. Food and Drug Administration’s (FDA) Expanded Access (EA) pathway provides a mechanism for these p
Externí odkaz:
https://doaj.org/article/b7e22100b74143d79fe0bce78d75488f
Autor:
Ozioma S. Chioma, Elizabeth K. Mallott, Austin Chapman, Joseph C. Van Amburg, Hongmei Wu, Binal Shah-Gandhi, Nandita Dey, Marina E. Kirkland, M. Blanca Piazuelo, Joyce Johnson, Gordon R. Bernard, Sobha R. Bodduluri, Steven Davison, Bodduluri Haribabu, Seth R. Bordenstein, Wonder P. Drake
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Direct modulation of the gut microbiota via rearing environments and fecal microbiota transplantation in a bleomycin-induced murine model suggests that a functional gut-lung axis modulates lung fibrosis.
Externí odkaz:
https://doaj.org/article/8dea445273114084825787a1400a2004
Autor:
Marisha E. Palm, Terri L. Edwards, Cortney Wieber, Marie T. Kay, Eve Marion, Leslie Boone, Angeline Nanni, Michelle Jones, Eilene Pham, Meghan Hildreth, Karen Lane, Nichol McBee, Daniel K. Benjamin, Gordon R. Bernard, J. Michael Dean, Jamie P. Dwyer, Daniel E. Ford, Daniel F. Hanley, Paul A. Harris, Consuelo H. Wilkins, Harry P. Selker
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
Improving the quality and conduct of multi-center clinical trials is essential to the generation of generalizable knowledge about the safety and efficacy of healthcare treatments. Despite significant effort and expense, many clinical trials are unsuc
Externí odkaz:
https://doaj.org/article/060484ec8a7846f58deebcc76c03128c
Autor:
Colleen E. Lawrence, Virginia (Nickie) M. Bruce, Libby D. Salberg, Terri Edwards, Casi Morales, Marisha Palm, Gordon R. Bernard
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
Contracting delays remain a challenge to the successful initiation of multisite clinical research in the US. The Clinical and Translational Science Awards (CTSA) Contracts Processing Study showed average contract negotiation duration of > 100 days fo
Externí odkaz:
https://doaj.org/article/a727c6a49c794ee482b9ebe3f7e2e1f6
Autor:
Daniel F. Hanley, Gordon R. Bernard, Consuelo H. Wilkins, Harry P. Selker, Jamie P. Dwyer, J. Michael Dean, Daniel Kelly Benjamin, Sarah E. Dunsmore, Salina P. Waddy, Kenneth L. Wiley, Marisha E. Palm, W. Andrew Mould, Daniel F. Ford, Jeri S. Burr, Jacqueline Huvane, Karen Lane, Lori Poole, Terri L. Edwards, Nan Kennedy, Leslie R. Boone, Jasmine Bell, Emily Serdoz, Loretta M. Byrne, Paul A. Harris
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
New technologies and disruptions related to Coronavirus disease-2019 have led to expansion of decentralized approaches to clinical trials. Remote tools and methods hold promise for increasing trial efficiency and reducing burdens and barriers by faci
Externí odkaz:
https://doaj.org/article/4a91e4af22ba4451850f5fca3e74db09
Autor:
Karen Lane, Marisha E. Palm, Eve Marion, Marie T. Kay, Dixie Thompson, Mary Stroud, Helen Boyle, Shannon Hillery, Angeline Nanni, Meghan Hildreth, Sarah Nelson, Jeri S. Burr, Terri Edwards, Lori Poole, Salina P. Waddy, Sarah E. Dunsmore, Paul Harris, Consuelo Wilkins, Gordon R. Bernard, J. Michael Dean, Jamie Dwyer, Daniel K. Benjamin, Harry P. Selker, Daniel F. Hanley, Daniel E. Ford
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
One challenge for multisite clinical trials is ensuring that the conditions of an informative trial are incorporated into all aspects of trial planning and execution. The multicenter model can provide the potential for a more informative environment,
Externí odkaz:
https://doaj.org/article/ba418e82daa04b61938979c76f95ceb6
Autor:
Akshitkumar M. Mistry, Jordan A. Magarik, Michael J. Feldman, Li Wang, Christopher J. Lindsell, Matthew R. Fusco, Rohan V. Chitale, Gordon R. Bernard, Wesley H. Self, Todd W. Rice, Christopher G. Hughes, Eva A. Mistry, Matthew W. Semler
Publikováno v:
Stroke: Vascular and Interventional Neurology, Vol 2, Iss 4 (2022)
Background Whether the composition of intravenous crystalloid solutions affects outcomes in adults with aneurysmal subarachnoid hemorrhage (aSAH) remains unknown. Therefore, we determined whether the use of saline is associated with a lower risk of d
Externí odkaz:
https://doaj.org/article/153633210c524fea9a7d8a64792ef145
Autor:
Wesley H. Self, Thomas G. Stewart, Allison P. Wheeler, Wissam El Atrouni, Amanda J. Bistran-Hall, Jonathan D. Casey, Vince D. Cataldo, James D. Chappell, Claudia S. Cohn, Jessica B. Collins, Mark R. Denison, Marjolein de Wit, Sheri L. Dixon, Abhijit Duggal, Terri L. Edwards, Magali J. Fontaine, Adit A. Ginde, Michelle S. Harkins, Thelma Harrington, Estelle S. Harris, Daanish Hoda, Tina S. Ipe, Stuti J. Jaiswal, Nicholas J. Johnson, Alan E. Jones, Maryrose Laguio-Vila, Christopher J. Lindsell, Jason Mallada, Manoj J. Mammen, Ryan A. Metcalf, Elizabeth A. Middleton, Simon Mucha, Hollis R. O’Neal, Sonal R. Pannu, Jill M. Pulley, Xian Qiao, Jay S. Raval, Jillian P. Rhoads, Harry Schrager, Carl Shanholtz, Nathan I. Shapiro, Stephen J. Schrantz, Isaac Thomsen, Krista K. Vermillion, Gordon R. Bernard, Todd W. Rice, For the Passive Immunity Trial for Our Nation (PassITON) Investigators
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Convalescent plasma is being used widely as a treatment for coronavirus disease 2019 (COVID-19). However, the clinical efficacy of COVID-19 convalescent plasma is unclear. Methods The Passive Immunity Trial for Our Nation (PassITO
Externí odkaz:
https://doaj.org/article/09f00f69e5d142a1b19dcc01b4acebd6
Autor:
Li Wang, Kevin G Buell, Roger K Richardson, Wesley H Self, Gordon R Bernard, Todd W Rice, Matthew W Semler, Robert E Freundlich, Jonathan D Casey, John Brems, Karen Jackson, Bradley D. Lloyd, Pamela G. Hastings, Margaret Hays, Megan Roth, Joanna Stollings, Kevin George Buell, Christopher J. Lindsell, Robert E. Freundlich, Jonathan P. Wanderer, Gordon R. Bernard, Wesley H. Self, Todd W. Rice, Jonathan P Wanderer, Christopher J Lindsell, Jin H Han, John H Brems, Sneha Patel, Joanna L Stollings, Christina Cleveland, Margaret A Hays, Luis E Huerta, Pamela G Hastings, Bradley D Lloyd, J Craig Rooks
Publikováno v:
BMJ Open, Vol 11, Iss 10 (2021)
Introduction Mechanical ventilation of intensive care unit (ICU) patients universally involves titration of the fraction of inspired oxygen to maintain arterial oxygen saturation (SpO2). However, the optimal SpO2 target remains unknown.Methods and an
Externí odkaz:
https://doaj.org/article/b94201b7da6c46cdbd4e55d9eea7a6fe
Autor:
Blake E. Funke, Karen E. Jackson, Wesley H. Self, Sean P. Collins, Christina T. Saunders, Li Wang, Jeffrey D. Blume, Nancy Wickersham, Ryan M. Brown, Jonathan D. Casey, Gordon R. Bernard, Todd W. Rice, Edward D. Siew, Matthew W. Semler, for the SMART Investigators, the Pragmatic Critical Care Research Group
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Recent trials have suggested use of balanced crystalloids may decrease the incidence of major adverse kidney events compared to saline in critically ill adults. The effect of crystalloid composition on biomarkers of early acute ki
Externí odkaz:
https://doaj.org/article/f72d1b5add4f47a5a4b450885f176a50