Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Gordon Powers"'
Autor:
Nate Majewski, Leopoldo Luistro, Gordon Powers, Rupesh Nanjunda, Diana Chin, Ricardo Attar, Francois Gaudet, Yingzhe Li, Kodandaram Pillarisetti, Xiaochun Zhang, Yusri Elsayed, Mark Mendonca, Packman Kathryn E, Alexander Babich, Baldwin Eric Thomas
Publikováno v:
Blood Adv
B-cell maturation antigen (BCMA), a member of the tumor necrosis factor family of receptors, is predominantly expressed on the surface of terminally differentiated B cells. BCMA is highly expressed on plasmablasts and plasma cells from multiple myelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c6644df1f5a77e89f1ddfec0da703a
https://doi.org/10.1182/bloodadvances.2020002393
https://doi.org/10.1182/bloodadvances.2020002393
Autor:
Nikki DeAngelis, Catherine Ferrante, Gordon Powers, Jocelyn Sendecki, Bethany Mattson, Darlene Pizutti, Kathryn Packman, Weirong Wang, Kevin Trouba, Rupesh Nanjunda, John Wheeler, Ray Brittingham, Sheng-Jiun Wu, Jinquan Luo, Matthew V. Lorenzi, Raluca I. Verona
Publikováno v:
Cancer chemotherapy and pharmacology. 89(4)
Purpose Preclinical characterization of cetrelimab (JNJ-63723283), a fully humanized immunoglobulin G4 kappa monoclonal antibody targeting programmed cell death protein-1 (PD-1), in human cancer models. Methods Cetrelimab was generated by phage panni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65f7a79203f381f3e394d4cf7ab1740
https://pubmed.ncbi.nlm.nih.gov/35298699
https://pubmed.ncbi.nlm.nih.gov/35298699
Autor:
Christine Springer, Adam Zwolak, Haiyan Jiang, Thomas C. Nesspor, Sanjaya Singh, Gordon Powers, Nicholas Mazzanti, Justin Sprenkle, Sherry L. La Porte, Kyle Kinealy, Michael D. Diem, Kevin Boye, Rajkumar Ganesan, Hunter Hoffman
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Generation of bispecific antibodies (BsAbs) having two unique Fab domains requires heterodimerization of the two heavy chains and pairing of each heavy chain with its cognate light chain. An alternative bispecific scaffold (Bipod) comprising an scFv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b20b1118aeab23ef074f3ba6fb10c72
https://doi.org/10.1038/s41598-020-64536-w
https://doi.org/10.1038/s41598-020-64536-w
Autor:
Gordon Powers, John R. Mabus, Amanda L. Kauffman, Jill Giles-Komar, Suzanne E. Thompson, Connie Kliwinski, Philip Cooper, Zhengyin Yan, Haimanti Dorai, Edwin Ragwan, Tam Susan H, Pamela J. Hornby, Benjamin C. Harman
Publikováno v:
Pharmaceutical Research
Purpose To evaluate transcytosis of immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) in adult primate intestine to determine whether this is a means for oral delivery of monoclonal antibodies (mAbs). Methods Relative regional expression of F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f95563014050779978fe39a5d022c1a
http://europepmc.org/articles/PMC3953555
http://europepmc.org/articles/PMC3953555
Autor:
Bernie Scallon, Rob Perkinson, Gordon Powers, Jill Giles-Komar, Susan H Tam, Connie Kliwinski, John R. Mabus, Teresa M Wilkinson, Pamela J. Hornby, Philip R. Cooper
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 304:G262-G270
Immunoglobulin G (IgG) is transcytosed across intestinal epithelial cells of suckling mammals by the neonatal Fc receptor (FcRn); however, the contribution of FcRn vs. FcRn-independent uptake to serum IgG levels had not been determined in either rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fa91da0e4c109cde44755adb181364
https://doi.org/10.1152/ajpgi.00340.2012
https://doi.org/10.1152/ajpgi.00340.2012
Autor:
Jill Giles-Komar, Erin Johnston, Natalie Fursov, Michael A. Rycyzyn, Haiyan Jiang, Gordon Powers, Karen E. Duffy, Jamie Fisher, Theodore Petley, Adam Cotty
Publikováno v:
Hybridoma. 30:153-162
ST2L is a transmembrane receptor that belongs to the IL-1 receptor family. The receptor is expressed on various cell types including Th2 cells, mast cells, basophils, growth-activated fibroblasts, and vascular endothelial cells. ST2L activation by it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584cc867a0af6035d68b074740c82abf
https://doi.org/10.1089/hyb.2010.0100
https://doi.org/10.1089/hyb.2010.0100
Autor:
Eilyn R. Lacy, Kimberly Staquet, Theodore Petley, Gordon Powers, Deborah Kwok, Michael A. Rycyzyn, Jill Giles-Komar
Publikováno v:
Human Antibodies. 15:155-162
The generation of anti-variable region monoclonal antibodies (mAbs) against therapeutic antibodies is essential in the pharmacokinetic/pharmacodynamic (PK/PD) assessments of the drugs in clinical study samples. Sandwich EIA and other methods are typi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17b7a17c2bedb15476b9151be7f79a6
https://doi.org/10.3233/hab-2006-15405
https://doi.org/10.3233/hab-2006-15405
Publikováno v:
SLAS Discovery. 1:187-190
A laboratory designed to carry out totally automated high throughput screening (HTS) assays was established recently at the Roche Research Center in Nutley, NJ. The system was designed by Sagian Inc. and uses an optimized robot for chemical analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1dcb24250eb522f373f49e5d2bf0009
https://doi.org/10.1177/108705719600100405
https://doi.org/10.1177/108705719600100405
Autor:
Allen Schantz, George Treacy, Deborah Kwok, Qun Jiao, Gordon Powers, Kathleen Van den Bulck, Zhao Zhou, Pauline L. Martin
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology.
BACKGROUND: Intetumumab is a human IgG1 anti-αv-integrin monoclonal antibody that inhibits angiogenesis. Integrin binding and angiogenesis are important in reproduction including fertilization, implantation, and embryofetal development. These studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799cd0479bc6ee3c66bdfea01a2ea807
https://doi.org/10.1002/bdrb.20232
https://doi.org/10.1002/bdrb.20232
Autor:
J. Fransen, W. Coussement, Peter Delille, Gordon Powers, Kathleen Van den Bulck, Pauline Martin, Deborah Kwok, Kathleen Vriens, Luc De Schaepdrijver
Publikováno v:
Reproductive Toxicology. 26:59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3e58ea7b266d5e4ae1e348df430efdf
https://doi.org/10.1016/j.reprotox.2008.05.010
https://doi.org/10.1016/j.reprotox.2008.05.010