Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Gordon P. Meares"'
Autor:
Sarah M. Milne, Anirudhya Lahiri, Cristina L. Sanchez, Micah J. Marshall, Ishrat Jahan, Gordon P. Meares
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Multiple sclerosis (MS) is an autoimmune demyelinating disease affecting the central nervous system (CNS). T helper (Th) 17 cells are involved in the pathogenesis of MS and its animal model of experimental autoimmune encephalomyelitis (EAE)
Externí odkaz:
https://doaj.org/article/b840da09b9c74c6686c210bf8b6b7e7d
Publikováno v:
ASN Neuro, Vol 13 (2021)
Nitric oxide (NO) is a versatile free radical that has been implicated in many biological processes (i.e., vasodilation, neurotransmission, and smooth muscle relaxation). High levels of NO, such as those produced by inducible NO synthase, are associa
Externí odkaz:
https://doaj.org/article/38849a585fbb49088c150cf93f7f1ba0
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract In many diseases, misfolded proteins accumulate within the endoplasmic reticulum (ER), leading to ER stress. In response, the cell initiates the unfolded protein response (UPR) to reestablish homeostasis. Additionally, in response to ER stre
Externí odkaz:
https://doaj.org/article/3f1160e39c86495c88208f8c2c5b0938
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-18 (2017)
Abstract Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate cell death. In neurodegenerative diseases, the accumulatio
Externí odkaz:
https://doaj.org/article/5ab4b0dedef049549607f178396ecd73
Autor:
Savannah G. Sims, Gordon P. Meares
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Neurodegenerative diseases are associated with the accumulation of misfolded proteins in the endoplasmic reticulum (ER), leading to ER stress. To adapt, cells initiate the unfolded protein response (UPR). However, severe or unresolved UPR activation
Externí odkaz:
https://doaj.org/article/1ee6647be84b4fd2b1f2c2e4ee693925
Publikováno v:
Glia. 70(1)
Astrocytes are glial cells that support neurological function in the central nervous system (CNS), in part, by providing structural support for neuronal synapses and blood vessels, participating in electrical and chemical transmission, and providing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594776d11307f001a3b0af0873d2e616
https://pubmed.ncbi.nlm.nih.gov/34462963
https://pubmed.ncbi.nlm.nih.gov/34462963
Publikováno v:
Journal of Neurochemistry. 148:516-530
Improper protein folding and trafficking are common pathological events in neurodegenerative diseases that result in the toxic accumulation of misfolded proteins within the lumen of the endoplasmic reticulum (ER). While low-level stimulation of the u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b10e0925311861521cf1b80496cced
https://doi.org/10.1111/jnc.14642
https://doi.org/10.1111/jnc.14642
Autor:
Chenbei Chang, Gordon P. Meares, Nicolas F. Berbari, Magda Gerigk, Rajani Rajbhandari, Markus Bredel, Amber L. Rowse, G. Kenneth Gray, Chih-Liang Tien, Susan Nozell, Sindhu Nair, Etty N. Benveniste, Kayln C. Mulhern, Samuel C. Fehling
Publikováno v:
Glia. 66:987-998
Previously, we determined microRNA-31 (miR-31) is a non-coding tumor suppressive gene frequently deleted in glioblastoma (GBM); miR-31 suppresses tumor growth, in part, by limiting the activity of NF-κB. Herein, we expand our previous studies by cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11525688eaacf2a9b3c86c872620100f
https://doi.org/10.1002/glia.23296
https://doi.org/10.1002/glia.23296
Publikováno v:
Journal of Biological Chemistry. 292:5239-5252
Previous studies have shown that glucagon cooperatively interacts with insulin to stimulate hepatic FGF21 gene expression. Here we investigated the mechanism by which glucagon and insulin increased FGF21 gene transcription in primary hepatocyte cultu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932ffd50ad2071db656e2a85d2451870
https://doi.org/10.1074/jbc.m116.762922
https://doi.org/10.1074/jbc.m116.762922
Autor:
Gesine Saher, Sergey Kalinin, Etty N. Benveniste, Shao Xia Lin, Sarah E. Lutz, Klaus-Armin Nave, Elizabeth A. Pietruczyk, Gordon P. Meares, Anne I. Boullerne, Lena Spieth, Douglas L. Feinstein
Publikováno v:
Glia
Liver kinase B1 (LKB1) is a ubiquitously expressed kinase involved in the regulation of cell metabolism, growth, and inflammatory activation. We previously reported that a single nucleotide polymorphism in the gene encoding LKB1 is a risk factor for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cdaf0bf4f3c2019990ce5d08668560
https://europepmc.org/articles/PMC7337013/
https://europepmc.org/articles/PMC7337013/
