Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Gordon O. Potts"'
Publikováno v:
Contraception. 24:289-299
Win 32,729 [(2 alpha, 4 alpha, 5 alpha, 17 beta)-4,5-epoxy-17-hydroxy-4,17-dimethyl-3-oxoandrostane-2-carbonitrile] is an orally active interceptive agent in rats and rhesus monkeys (M mulatta). A single oral dose of 48 mg/kg terminated gestation whe
Publikováno v:
Fertility and Sterility. 25:367-372
A steroid danazol (17-alpha-Pregn-4-en-20-yno(23-d)-isoxazol-17-ol) possesses a marked separation of pituitary gonadotropin inhibitory activity from overt sex hormonal activities. The effect of danazol on fertility in the rat was determined. Danazol
Autor:
Ludwig Kiesel, Josef Kellermann, Gordon O. Potts, Benno Runnebaum, Thomas Rabe, Klaus Weidenhammer
Publikováno v:
Fertility and Sterility. 39:829-835
The inhibitory effect in vitro of four synthetic steroids on enzyme systems of placental progesterone synthesis at term was analyzed. Cholesterol side chain cleavage enzyme (CSCC) was not influenced by azastene, trilostane, and WIN 32,729. A 50% inhi
Publikováno v:
Fertility and Sterility. 30:86-90
Azastene (4,4,17α-trimethylandrost-5-eno [2,3-d]isoxazol-17-ol), when given orally to rats at a dose of 12 mg/kg once on day 10 of pregnancy, induced resorption of all fetuses and a precipitous decline of circulating progesterone levels in all test
Publikováno v:
Fertility and Sterility. 30:343-347
Azastene is an orally effective "luteolytic" agent in rhesus monkeys. In nonpregnant monkeys it reverses the human chorionic gonadotropin-stimulated increase in progesterone production and delay in the onset of menstruation, and in inseminated monkey
Publikováno v:
Endocrinology. 69:819-833
N,N′-4-Xylylene-bis(N-ethyldichloroacetamide), Compound I,and N,N′-bis (dichloroacetyl)-l,8-octamethylenediamine, Compound II, produced in rats marked testicular weight regression associated with complete arrest of spermatogenesis. Compound II wa
Publikováno v:
Endocrinology. 67:849-854
The myotrophic and nitrogen retaining effects of five steroids (methyltestosterone; methylandrostenediol; 17α-methylandrosta-4,6-diene-17β-ol-3-one; 19-nor-17α-methylandrost-5 (10) eno-17β-ol-3-one and 17β-hydroxy-17α:-methylandrost-4-eno[3,2-c
Publikováno v:
Endocrinology. 88:427-432
Estrone and estradiol-17β were shown to displace 3H-estradiol-17β from binding sites in plasma of the pregnant rat. The ligand specificity of this plasma differed from that of human pregnancy plasma. In the rat preparation, neither testosterone nor
Autor:
K. F. Jennings, Franklyn W. Gubitz, Robert L. Clarke, Philip E. Shaw, Gordon O. Potts, A. L. Beyler
Publikováno v:
Journal of Medicinal Chemistry. 7:555-560
Publikováno v:
Journal of Medicinal Chemistry. 13:948-951