Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Gordon Ng"'
Autor:
Nina E. Weisser, Mario Sanches, Eric Escobar-Cabrera, Jason O’Toole, Elizabeth Whalen, Peter W. Y. Chan, Grant Wickman, Libin Abraham, Kate Choi, Bryant Harbourne, Antonios Samiotakis, Andrea Hernández Rojas, Gesa Volkers, Jodi Wong, Claire E. Atkinson, Jason Baardsnes, Liam J. Worrall, Duncan Browman, Emma E. Smith, Priya Baichoo, Chi Wing Cheng, Joy Guedia, Sohyeong Kang, Abhishek Mukhopadhyay, Lisa Newhook, Anders Ohrn, Prajwal Raghunatha, Matteo Zago-Schmitt, Joseph D. Schrag, Joel Smith, Patricia Zwierzchowski, Joshua M. Scurll, Vincent Fung, Sonia Black, Natalie C. J. Strynadka, Michael R. Gold, Leonard G. Presta, Gordon Ng, Surjit Dixit
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent cyt
Externí odkaz:
https://doaj.org/article/8a871ad93e594eeba832492229b1329b
Autor:
Mario Sanches, Igor D’Angelo, Maria Jaramillo, Jason Baardsnes, John Zwaagstra, Joe Schrag, Ian Schoenhofen, Mauro Acchione, Sam Lawn, Grant Wickman, Nina Weisser, David K. Y. Poon, Gordon Ng, Surjit Dixit
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
As biologics have become a mainstay in the development of novel therapies, protein engineering tools to expand on their structural advantages, namely specificity, affinity, and valency are of interest. Antibodies have dominated this field as the pref
Externí odkaz:
https://doaj.org/article/a5ed50a220974d43b325471bef850d35
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4695 (2009)
BACKGROUND: Nitrogen (N(2)) fixation also yields hydrogen (H(2)) at 1:1 stoichiometric amounts. In aerobic diazotrophic (able to grow on N(2) as sole N-source) bacteria, orthodox respiratory hupSL-encoded hydrogenase activity, associated with the cel
Externí odkaz:
https://doaj.org/article/234fc973cee04c5d98d8e0b1e1c2ed9b
Publikováno v:
Building Services Engineering Research and Technology. 43:645-664
To mitigate the climate change issue, the Government of the Hong Kong Special Administrative Region (HKSAR) proposed the “Hong Kong Climate Change Plan 2030+” with an ambitious goal of reducing the carbon intensity to 65%–70% below 2005 levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d47a20668dfc74f045291d96f05650d6
https://doi.org/10.1177/01436244221088778
https://doi.org/10.1177/01436244221088778
Publikováno v:
Preventive Care in Nursing and Midwifery Journal, Vol 13, Iss 3, Pp 27-39 (2023)
Background: Malnutrition is deficiencies or excess nutrients by an individual. Includes under-nutrition and micronutrient-related malnutrition. It causes about half of all fatalities in children below five years; increases the chance of a child dying
Externí odkaz:
https://doaj.org/article/7e8aeb8eb80b4df5a352d0b45896d67a
Autor:
Andrea Itano, John Ferbas, Lei Zhou, Esther S. Trueblood, Xuxia Zhang, Gloria Juan, Efrain Pacheco, Gordon Ng, Stephen J. Zoog
Publikováno v:
Cytometry Part A. :189-198
Mast cells (MCs) have important functional roles in leukocyte recruitment, pain, and wound healing, and increased tissue resident MC function has been associated with several fibrotic diseases. Consequently, the study of MCs in situ can be a direct a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf5c7ea6af6e6dc77fcce315400131b
https://doi.org/10.1002/cyto.a.20658
https://doi.org/10.1002/cyto.a.20658
Autor:
Ning Chen, Andrea Itano, Randall W. Hungate, Ryan White, Yang Xu, Matthew H. Plant, Yanyan Tudor, Yen Nguyen, Roxanne Kunz, Perry M. Novak, Kristin Meagher, Essa Hu, Jason Brooks Human, Shaun Flynn, Gordon Ng, Xuxia Zhang, Violeta Yu, Roland Burli, Douglas A. Whittington, Andrew Tasker
Publikováno v:
Journal of Medicinal Chemistry. 51:3065-3068
Inhibition of c-Kit has the potential to treat mast cell associated fibrotic diseases. We report the discovery of several aminoquinazoline pyridones that are potent inhibitors of c-Kit with greater than 200-fold selectivity against KDR, p38, Lck, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81447f11bfae7a4d16eb01799010756e
https://doi.org/10.1021/jm800188g
https://doi.org/10.1021/jm800188g
Autor:
Burgess Laurence E, Leyla Arik, Chester Chenguang Yuan, Nianhe Han, Randall W. Hungate, Derin C. D'amico, David A. Mareska, Feng-Yin Hsieh, Eileen Johnson, Hong Sun, Qingyian Liu, Barton H. Manning, Bobby Riahi, Christopher H. Fotsch, Gloria Biddlecome, Mark H. Norman, Augustus Kamassah, Ming Huang, Richard Loeloff, Gondi N. Kumar, Andras Toro, Jian J. Chen, Jason Brooks Human, Hideo Suzuki, Robert D. Groneberg, Benny C. Askew, Aiwen Li, Gordon Ng, James Zhan, Kaustav Biswas, Dianna Lester-Zeiner, Hong Dong, David E. Clarke
Publikováno v:
Journal of Medicinal Chemistry. 50:2200-2212
The bradykinin B1 receptor is induced following tissue injury and/or inflammation. Antagonists of this receptor have been studied as promising candidates for treatment of chronic pain. We have identified aryl sulfonamides containing a chiral chroman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb42b5aad05a1dc5bda8d29f83bc6dc6
https://doi.org/10.1021/jm070055c
https://doi.org/10.1021/jm070055c
Autor:
Roland Burli, Matthew H. Plant, Randall W. Hungate, Roxanne Kunz, Douglas A. Whittington, Yang Xu, Shannon Rumfelt, Gordon Ng, Violeta Yu, Michael Schrag, Ning Chen, Yen Nguyen, Yanyan Tudor, Andrew Tasker, Kristin Meagher, Essa Hu, Dawei Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5115-5117
Deregulation of the receptor tyrosine kinase c-Kit is associated with an increasing number of human diseases, including certain cancers and mast cell diseases. Interference of c-Kit signaling with multi-kinase inhibitors has been shown clinically to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd2f15cb2f6855f01eb5d331d0b8302
https://doi.org/10.1016/j.bmcl.2008.07.111
https://doi.org/10.1016/j.bmcl.2008.07.111
Publikováno v:
The Journal of hand surgery. 35(4)
Purpose To compare volar, dorsal, and custom splinting techniques in acute Doyle I mallet finger injuries. Methods We developed a radiographic lag measurement using the contralateral normal digit as an internal control for establishing the approximat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475e8c074319a77fea98a21fc38e8330
https://pubmed.ncbi.nlm.nih.gov/20353859
https://pubmed.ncbi.nlm.nih.gov/20353859