Zobrazeno 1 - 10
of 439
pro vyhledávání: '"Gordon Marcia"'
Autor:
Ridnour Lisa A, Taylor Tiffany L, Gordon Marcia N, Morgan Dave, Wilcock Donna M, Wink David A, Colton Carol A
Publikováno v:
Journal of Neuroinflammation, Vol 8, Iss 1, p 115 (2011)
Abstract Background Anti-Aβ immunotherapy is a promising approach to the prevention and treatment of Alzheimer's disease (AD) currently in clinical trials. There is extensive evidence, both in mice and humans that a significant adverse event is the
Externí odkaz:
https://doaj.org/article/09300d265ca8403790230d1b039be1f9
Autor:
Gordon Marcia N, Blair Laura, Johnson Amelia, Kraft Clara, Reid Patrick, Selenica Maj-Linda B, Rizer Justin, Lee Daniel C, Dickey Chad A, Morgan Dave
Publikováno v:
Journal of Neuroinflammation, Vol 7, Iss 1, p 56 (2010)
Abstract Inflammation and microglial activation are associated with Alzheimer's disease (AD) pathology. Somewhat surprisingly, injection of a prototypical inflammatory agent, lipopolysaccharide (LPS) into brains of amyloid precursor protein (APP) tra
Externí odkaz:
https://doaj.org/article/bf135ff08d18407bb0f5de1a2b62cce6
Publikováno v:
BMC Neuroscience, Vol 8, Iss 1, p 22 (2007)
Abstract Background Prior work from our group found that acid dissociation (pH 2.5 incubation) of serum from APP transgenic mice vaccinated against Aβ increased the apparent anti-Aβ titers, suggesting antibody masking by antigen in the ELISA assay.
Externí odkaz:
https://doaj.org/article/48a15ae424c44daa9a193016778bb167
Autor:
Gordon Marcia N, Gottschall Paul E, Pons Jaume, Ronan Victoria, Grimm Jan, Rosenthal Arnon, Wilcock Donna M, Carty Niki C, Morgan Dave
Publikováno v:
Journal of Neuroinflammation, Vol 3, Iss 1, p 11 (2006)
Abstract Background Antibodies against the Aß peptide clear Aß deposits when injected intracranially. Deglycosylated antibodies have reduced effector functions compared to their intact counterparts, potentially avoiding immune activation. Methods D
Externí odkaz:
https://doaj.org/article/40ae9459dc1e4d1baebf639d3c2bd36e
Autor:
Freeman Melissa J, Herber Donna L, Wilcock Donna M, Gordon Marcia N, Dickey Chad A, Morgan Dave
Publikováno v:
BMC Neuroscience, Vol 6, Iss 1, p 7 (2005)
Abstract Background The pathology of Alzheimer's disease (AD) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and neurodegeneration. The mechanisms by which these various pathological features arise are u
Externí odkaz:
https://doaj.org/article/f970a16ada5144ed98158cdd459bdd8f
Autor:
Gordon Marcia N, Freeman Melissa J, Subbarao Sangeetha, Rosenthal Arnon, Rojiani Amyn, Wilcock Donna M, Morgan Dave
Publikováno v:
Journal of Neuroinflammation, Vol 1, Iss 1, p 24 (2004)
Abstract Background Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates. As most Alzheimer disease cases occur well past midlife, the curr
Externí odkaz:
https://doaj.org/article/33dc253f442646ecb838245ea519661f
Autor:
Ugen Kenneth E, Gordon Marcia, Schiller John, Chackerian Bryce, Cao Chuanhai, Li Qingyou, Morgan Dave
Publikováno v:
BMC Neuroscience, Vol 5, Iss 1, p 21 (2004)
Abstract Background In prior work we detected reduced anti-Aβ antibody titers in Aβ-vaccinated transgenic mice expressing the human amyloid precursor protein (APP) compared to nontransgenic littermates. We investigated this observation further by v
Externí odkaz:
https://doaj.org/article/2f2bc09953134b808d1ce01319a44e24
Autor:
Tetlow, Amber M., Jackman, Brianna M., Alhadidy, Mohammed M., Muskus, Patricia, Morgan, David G., Gordon, Marcia N.
Publikováno v:
In Neurobiology of Aging April 2023 124:39-50
Publikováno v:
In Clinics in Geriatric Medicine February 2023 39(1):109-122
Autor:
Finneran, Dylan J., Desjarlais, Taylor, Henry, Alayna, Jackman, Brianna M., Gordon, Marcia N., Morgan, David
Publikováno v:
Alzheimer's & Dementia: Translational Research & Clinical Interventions; Apr2024, Vol. 10 Issue 2, p1-13, 13p