Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Gordon M. Wahler"'
1
Inhibition of cyclic GMP hydrolysis with zaprinast reduces basal and cyclic AMP-elevated L-type calcium current in guinea-pig ventricular myocytes
Autor: Susanne J Lewandowski, Fred D. Romano, Mark T. Ziolo, Gordon M. Wahler, Jacquelyn M. Smith
Publikováno v: British Journal of Pharmacology. 138:986-994
Cyclic GMP (cGMP) has been shown to be an important modulator of cardiac contractile function. A major component of cGMP regulation of contractility is cGMP-mediated inhibition of the cardiac calcium current (ICa). An under-appreciated aspect of cycl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39499ac5043f24a1e3340d4bf36022f0
https://doi.org/10.1038/sj.bjp.0705112
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2
Myocytes Isolated from Rejecting Transplanted Rat Hearts Exhibit a Nitric Oxide-mediated Reduction in the Calcium Current
Autor: Mark T. Ziolo, Gordon M. Wahler, Jacquelyn M. Smith, Korie L. Sondgeroth, Fred D. Romano, Carol H. Harshbarger, Karen E. Roycroft
Publikováno v: Journal of Molecular and Cellular Cardiology. 33:1691-1699
During periods of acute rejection, transplanted hearts have increased nitric oxide (NO) production and depressed contractile function. Myocytes isolated from rejecting hearts exhibit parallel increases in NO production and reduced shortening, indicat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c21f0464183cbea8d8b38f59a1d326
https://doi.org/10.1006/jmcc.2001.1420
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3
Anti-adrenergic effects of nitric oxide donor SIN-1 in rat cardiac myocytes
Autor: Gordon M. Wahler, Miroslav O. Stojanovic, Beata M. Wolska, Mark T. Ziolo
Publikováno v: American Journal of Physiology-Cell Physiology. 281:C342-C349
We studied how the nitric oxide (NO·) donor 3-morpholinosydnonimine (SIN-1) alters the response to β-adrenergic stimulation in cardiac rat myocytes. We found that SIN-1 decreases the positive inotropic effect of isoproterenol (Iso) and decreases th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8503aacba3f6b7aa6d04e6c1c9a74953
https://doi.org/10.1152/ajpcell.2001.281.1.c342
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4
[Untitled]
Autor: Mark T. Ziolo, Jacquelyn M. Smith, Gordon M. Wahler, Korie Sondgeroth, C H Harshbarger
Publikováno v: Molecular and Cellular Biochemistry. 220:169-175
Accumulation of lipid metabolites, such as palmitoylcarnitine and lysophosphatidylcholine, is thought to be a major contributor to the development of cardiac arrhythmias during myocardial ischemia. This arrhythmogenicity is likely due to the effects
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcc794764b77c71aa6a5d4c10d5d3873
https://doi.org/10.1023/a:1010992900387
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5
Ventricular myocytes isolated from rejecting cardiac allografts exhibit a reduced ?-adrenergic contractile response
Autor: Gordon M. Wahler, Robert T. Pyo
Publikováno v: Journal of Molecular and Cellular Cardiology. 27:773-776
R. T. Pyo and G. M. Wahler . Ventricular Myocytes Isolated from Rejecting Cardiac Allografts Exhibit a Reduced β-Adrenergic Contractile Response. Journal of Molecular and Cellular Cardiology (1995) 27 , 773–776. Previous experiments using multicel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bdb3ba79eef09f4b4bd161cd25582f
https://doi.org/10.1016/0022-2828(95)90083-7
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6
Regulation of Cardiac Ion Channels by Cyclic Nucleotide-Dependent Phosphorylation
Autor: Gordon M. Wahler, Nick Sperelakis
Ion channels in the heart are regulated by many physiological mechanisms. One of the most important mechanisms is the regulation by cyclic nucleotide protein kinases. Calcium channels in the heart play a central role in excitation–contraction coupl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5fd0241a1ca40f4b1e2ed1e3b76e77d
https://doi.org/10.1016/b978-0-12-387738-3.00023-8
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8
Cardiac Action Potentials
Autor: Gordon M. Wahler
Publikováno v: Heart Physiology and Pathophysiology (Fourth Edition)
Publisher Summary This chapter reviews the characteristics of the cardiac action potential (AP), with emphasis on major currents responsible for the various components or phases of the APs, as well as the regional differences in cardiac APs. Some car
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f581b2c2f45c3d34dae2ee061adfda26
https://doi.org/10.1016/b978-0-12-387738-3.00043-3
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10
Inhibition of nitric oxide synthase enhances contractile response of ventricular myocytes from streptozotocin-diabetic rats
Autor: Jacquelyn M. Smith, Gordon M. Wahler, Korie B. Sondgeroth
Publikováno v: Molecular and cellular biochemistry. 300(1-2)
The contractile hyporesponsiveness of the streptozotocin diabetic rat heart in vitro to beta-adrenergic agonists is eliminated when the heart is perfused with N(G)-nitro-L-arginine methyl ester (L-NAME), a non-selective inhibitor of nitric oxide synt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676defbded54cecde32a81201e96f8c6
https://pubmed.ncbi.nlm.nih.gov/17225190
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