Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Gordon Langsley"'
Publikováno v:
PLoS ONE, Vol 19, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/203260314bcb429eb58e69fbbe79211c
Autor:
Deepika Kannan, Nishant Joshi, Sonal Gupta, Soumya Pati, Souvik Bhattacharjee, Gordon Langsley, Shailja Singh
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Despite several initiatives to subside the global malaria burden, the spread of artemisinin-resistant parasites poses a big threat to malaria elimination. Mutations in PfKelch13 are predictive of ART resistance, whose underpinning molecular
Externí odkaz:
https://doaj.org/article/82d00e0c4ef44b33840f130c2bce8b29
Autor:
Shahin Tajeri, Laurence Momeux, Benjamin Saintpierre, Sara Mfarrej, Alexander Chapple, Tobias Mourier, Brian Shiels, Frédéric Ariey, Arnab Pain, Gordon Langsley
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract A fungal metabolite, FR235222, specifically inhibits a histone deacetylase of the apicomplexan parasite Toxoplasma gondii and TgHDAC3 has emerged as a key factor regulating developmental stage transition in this species. Here, we exploited F
Externí odkaz:
https://doaj.org/article/b9dd82b8dc624f799c5869c9c2809f6c
Autor:
Malak Haidar, Shahin Tajeri, Laurence Momeux, Tobias Mourier, Fathia Ben-Rached, Sara Mfarrej, Zineb Rchiad, Arnab Pain, Gordon Langsley
Publikováno v:
mSphere, Vol 8, Iss 2 (2023)
ABSTRACT MicroRNAs (miRNAs) are small noncoding RNAs that can play critical roles in regulating various cellular processes, including during many parasitic infections. Here, we report a regulatory role for miR-34c-3p in cAMP-independent regulation of
Externí odkaz:
https://doaj.org/article/5923448cb02e41e5afce276252ffe6f2
Autor:
Edwin Lasonder, Kunal More, Shailja Singh, Malak Haidar, Daniela Bertinetti, Eileen J. Kennedy, Friedrich W. Herberg, Anthony A. Holder, Gordon Langsley, Chetan E. Chitnis
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
We review the role of signaling pathways in regulation of the key processes of merozoite egress and red blood cell invasion by Plasmodium falciparum and, in particular, the importance of the second messengers, cAMP and Ca2+, and cyclic nucleotide dep
Externí odkaz:
https://doaj.org/article/de12574100264a50a9905dfa1595a22b
Autor:
Kunal R. More, Inderjeet Kaur, Quentin Giai Gianetto, Brandon M. Invergo, Thibault Chaze, Ravi Jain, Christéle Huon, Petra Gutenbrunner, Hendrik Weisser, Mariette Matondo, Jyoti S. Choudhary, Gordon Langsley, Shailja Singh, Chetan E. Chitnis
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Red blood cell (RBC) invasion by Plasmodium merozoites requires multiple steps that are regulated by signaling pathways. Exposure of P. falciparum merozoites to the physiological signal of low K+, as found in blood plasma, leads to a rise in
Externí odkaz:
https://doaj.org/article/cf8e5574eaf442db8acf7c08a6cec1bf
Autor:
Judith L Green, Yang Wu, Vesela Encheva, Edwin Lasonder, Adchara Prommaban, Simone Kunzelmann, Evangelos Christodoulou, Munira Grainger, Ngoc Truongvan, Sebastian Bothe, Vikram Sharma, Wei Song, Irene Pinzuti, Chairat Uthaipibull, Somdet Srichairatanakool, Veronique Birault, Gordon Langsley, Hermann Schindelin, Benjamin Stieglitz, Ambrosius P Snijders, Anthony A Holder
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008640 (2020)
Ubiquitylation is a common post translational modification of eukaryotic proteins and in the human malaria parasite, Plasmodium falciparum (Pf) overall ubiquitylation increases in the transition from intracellular schizont to extracellular merozoite
Externí odkaz:
https://doaj.org/article/02cebcacd3f549579a7e6b82f7f59588
Autor:
Kannan Venugopal, Sylia Chehade, Elisabeth Werkmeister, Nicolas Barois, Javier Periz, Frank Lafont, Isabelle Tardieux, Jamal Khalife, Gordon Langsley, Markus Meissner, Sabrina Marion
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008106 (2020)
Toxoplasma gondii possesses an armada of secreted virulent factors that enable parasite invasion and survival into host cells. These factors are contained in specific secretory organelles, the rhoptries, micronemes and dense granules that release the
Externí odkaz:
https://doaj.org/article/a239896d92e9456983b20a04c3aed2a7
Autor:
Margaret M. Harnett, Miguel A. Pineda, Perle Latré de Laté, Russell J. Eason, Sébastien Besteiro, William Harnett, Gordon Langsley
Publikováno v:
Biomedical Journal, Vol 40, Iss 1, Pp 9-22 (2017)
Christian de Duve first coined the expression “autophagy” during his seminal work on the discovery of lysosomes, which led to him being awarded the Nobel Prize in Physiology or Medicine in 1974. The term was adopted to distinguish degradation of
Externí odkaz:
https://doaj.org/article/2948d31d73ee497581f6e5cfd1be66d8
Autor:
Perle Laté de Laté, Miguel Pineda, Margaret Harnett, William Harnett, Sébastien Besteiro, Gordon Langsley
Publikováno v:
Biomedical Journal, Vol 40, Iss 1, Pp 23-30 (2017)
Apicomplexan parasites are responsible for a number of important human pathologies. Obviously, as Eukaryotes they share a number of cellular features and pathways with their respective host cells. One of them is autophagy, a process involved in the d
Externí odkaz:
https://doaj.org/article/6d7d62a523514b11acb3de736aa794c4