Zobrazeno 1 - 10
of 322
pro vyhledávání: '"Gordon L Hager"'
Autor:
Benjamin P Flynn, Matthew T Birnie, Yvonne M Kershaw, Audrys G Pauza, Sohyoung Kim, Songjoon Baek, Mark F Rogers, Alex R Paterson, Diana A Stavreva, David Murphy, Gordon L Hager, Stafford L Lightman, Becky L Conway-Campbell
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009737 (2021)
Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynam
Externí odkaz:
https://doaj.org/article/ebb7253002144d5885d6bce3701f46a0
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148619 (2016)
Bone continuously undergoes remodeling by a tightly regulated process that involves osteoblast differentiation from Mesenchymal Stem Cells (MSC). However, commitment of MSC to osteoblastic lineage is a poorly understood process. Chromatin organizatio
Externí odkaz:
https://doaj.org/article/ebd0f0c5c7624851996de9c446e478d4
Autor:
Diana A. Stavreva, Lyuba Varticovski, Razi Raziuddin, Gianluca Pegoraro, R. Louis Schiltz, Gordon L. Hager
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Progesterone receptor (PR)-interacting compounds in the environment are associated with serious health hazards. However, methods for their detection in environmental samples are cumbersome. We report a sensitive activity-based biosensor for
Externí odkaz:
https://doaj.org/article/22d46109ab134ab3baf024db0dc843bd
Autor:
Michael J Guertin, Xuesen Zhang, Lynne Anguish, Sohyoung Kim, Lyuba Varticovski, John T Lis, Gordon L Hager, Scott A Coonrod
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004613 (2014)
Transcription factor binding to DNA in vivo causes the recruitment of chromatin modifiers that can cause changes in chromatin structure, including the modification of histone tails. We previously showed that estrogen receptor (ER) target gene activat
Externí odkaz:
https://doaj.org/article/d79172572fd04312930a70daf5e6a5b8
Autor:
Diego M Presman, M Florencia Ogara, Martín Stortz, Lautaro D Alvarez, John R Pooley, R Louis Schiltz, Lars Grøntved, Thomas A Johnson, Paul R Mittelstadt, Jonathan D Ashwell, Sundar Ganesan, Gerardo Burton, Valeria Levi, Gordon L Hager, Adali Pecci
Publikováno v:
PLoS Biology, Vol 12, Iss 3, p e1001813 (2014)
Glucocorticoids are essential for life, but are also implicated in disease pathogenesis and may produce unwanted effects when given in high doses. Glucocorticoid receptor (GR) transcriptional activity and clinical outcome have been linked to its olig
Externí odkaz:
https://doaj.org/article/cfa4984d0eee4478bf994e7833b6c058
Autor:
Hatice Z Nenseth, Xavier Dezitter, Martina Tesikova, Florian Mueller, Tove I Klokk, Gordon L Hager, Fahri Saatcioglu
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105204 (2014)
Closely related transcription factors (TFs) can bind to the same response elements (REs) with similar affinities and activate transcription. However, it is unknown whether transcription is similarly orchestrated by different TFs bound at the same RE.
Externí odkaz:
https://doaj.org/article/7b9d5bd673ac4ec1982ca95b23ed54a7
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e76043 (2013)
Genes are regulated at the single-cell level. Here, we performed RNA FISH of thousands of cells by flow cytometry (flow-RNA FISH) to gain insight into transcriptional variability between individual cells. These experiments utilized the murine adenoca
Externí odkaz:
https://doaj.org/article/a476287399234e8783b294019ec787c1
Autor:
Myong-Hee Sung, Luigi Salvatore, Rossana De Lorenzi, Anindya Indrawan, Manolis Pasparakis, Gordon L Hager, Marco E Bianchi, Alessandra Agresti
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7163 (2009)
NF-kappaB is a prototypic stress-responsive transcription factor that acts within a complex regulatory network. The signaling dynamics of endogenous NF-kappaB in single cells remain poorly understood. To examine real time dynamics in living cells, we
Externí odkaz:
https://doaj.org/article/8c1e07fde039464bbbd73020c8f21732
Autor:
Massimiliano Bissa, Sohyoung Kim, Veronica Galli, Slim Fourati, Sarkis Sarkis, Anush Arakelyan, Isabela Silva de Castro, Mohammad Arif Rahman, Saori Fujiwara, Monica Vaccari, Jeffrey A. Tomalka, James D. Stamos, Luca Schifanella, Giacomo Gorini, Ramona Moles, Anna Gutowska, Guido Ferrari, Alexei Lobanov, David C. Montefiori, George W. Nelson, Margaret C. Cam, Marita Chakhtoura, Elias K. Haddad, Melvin N. Doster, Katherine McKinnon, Sophia Brown, David J. Venzon, Hyoyoung Choo-Wosoba, Matthew W. Breed, Kristin E. Killoran, Joshua Kramer, Leonid Margolis, Rafick P. Sekaly, Gordon L. Hager, Genoveffa Franchini
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
HIV vaccine development can be aided by knowledge of correlates of protection. Here the authors identify engagement and reprogramming of tolerogenic CD14+ myeloid cells mediating a spatiotemporal balance of pro- and anti-inflammatory responses, as co
Externí odkaz:
https://doaj.org/article/f273918f9336463f8dcd9cedb0b73046
Autor:
Nupur Nigam, Benjamin Bernard, Samantha Sevilla, Sohyoung Kim, Mohd Saleem Dar, Daniel Tsai, Yvette Robbins, Kyunghee Burkitt, Cem Sievers, Clint T. Allen, Richard L. Bennett, Theophilus T. Tettey, Benjamin Carter, Lorenzo Rinaldi, Mark W. Lingen, Houssein Sater, Elijah F. Edmondson, Arfa Moshiri, Abbas Saeed, Hui Cheng, Xiaolin Luo, Kevin Brennan, Vishal Koparde, Chen Chen, Sudipto Das, Thorkell Andresson, Abdalla Abdelmaksoud, Madhavi Murali, Seiji Sakata, Kengo Takeuchi, Raj Chari, Yusuke Nakamura, Ravindra Uppaluri, John B. Sunwoo, Carter Van Waes, Jonathan D. Licht, Gordon L. Hager, Vassiliki Saloura
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112823- (2023)
Summary: Cancers often display immune escape, but the mechanisms are incompletely understood. Herein, we identify SMYD3 as a mediator of immune escape in human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC), an aggressiv
Externí odkaz:
https://doaj.org/article/b0940346e8a34a0c84bdf4ba79034b75