Zobrazeno 1 - 10
of 285
pro vyhledávání: '"Gordon K. Wilcock"'
Autor:
Ludovica Griffanti, Gordon K. Wilcock, Natalie Voets, Guendalina Bonifacio, Clare E. Mackay, Mark Jenkinson, Giovanna Zamboni
Publikováno v:
Dementia and Geriatric Cognitive Disorders Extra, Vol 6, Iss 3, Pp 518-528 (2016)
Background: We have previously shown that increased resting-state functional magnetic resonance imaging (fMRI)-based functional connectivity (FC) within the frontal resting-state networks in Alzheimer's disease (AD) patients reflects residual, possib
Externí odkaz:
https://doaj.org/article/fe5121a45fc642d795f9b7aae6faf2fa
Autor:
Michal Rolinski, Ludovica Griffanti, Konrad Szewczyk-Krolikowski, Ricarda A.L. Menke, Gordon K. Wilcock, Nicola Filippini, Giovanna Zamboni, Michele T.M. Hu, Clare E. Mackay
Publikováno v:
NeuroImage: Clinical, Vol 8, Iss C, Pp 126-132 (2015)
Resting state functional MRI (rs-fMRI) has been previously shown to be a promising tool for the assessment of early Parkinson's disease (PD). In order to assess whether changes within the basal ganglia network (BGN) are disease specific or relate to
Externí odkaz:
https://doaj.org/article/4b813286d469411594d1a60a762dc26f
Publikováno v:
Neurobiology of Disease, Vol 9, Iss 1, Pp 82-87 (2002)
We previously found that herpes simplex type 1 virus (HSV1), when present in brain of carriers of the apolipoprotein E type 4 allele is a strong risk factor for Alzheimer's disease. To find if HSV1 or certain other herpesviruses are involved in vascu
Externí odkaz:
https://doaj.org/article/bc2d60c60f3845249fab5c63dec68508
Autor:
Simon Lovestone, Rosie Bradley, Rupert McShane, John T. O'Brien, Lynn Pank, Suzanne Reeves, G Livingston, Craig W. Ritchie, Gordon K. Wilcock, Chris Fox, Alistair Burns, Naji Tabet, Peter Bentham, Emma Harper, Robert Howard, Ramin Nilforooshan, Richard Gray, Wendy Noble, Linda Kelly, Olga Zubko, Clive Ballard
Publikováno v:
Howard, R, Zubko, O, Gray, R, Bradley, R, Harper, E, Kelly, L, Pank, L, O’brien, J, Fox, C, Tabet, N, Livingston, G, Bentham, P, Mcshane, R, Burns, A, Ritchie, C, Reeves, S, Lovestone, S, Ballard, C, Noble, W, Wilcock, G & Nilforooshan, R 2020, ' Minocycline 200 mg or 400 mg versus placebo for mild Alzheimer’s disease: the MADE Phase II, three-arm RCT ', Efficacy and Mechanism Evaluation, vol. 7, no. 2 . https://doi.org/10.3310/eme07020
Efficacy and Mechanism Evaluation, Vol 7, Iss 2 (2020)
Howard, R, Zubko, O, Gray, R, Bradley, R, Harper, E, Kelly, L, Pank, L, O'Brien, J, Fox, C, Tabet, N, Livingston, G, Bentham, P, McShane, R, Burns, A, Ritchie, C, Reeves, S, Lovestone, S, Ballard, C, Noble, W, Wilcock, G & Nilforooshan, R 2020, ' Minocycline 200 mg or 400 mg versus placebo for mild Alzheimer’s disease: the MADE Phase II, three-arm RCT ', Efficacy and Mechanism Evaluation, vol. 7, no. 2, 7(2), pp. 1-45 . https://doi.org/10.3310/eme07020
Efficacy and Mechanism Evaluation, Vol 7, Iss 2 (2020)
Howard, R, Zubko, O, Gray, R, Bradley, R, Harper, E, Kelly, L, Pank, L, O'Brien, J, Fox, C, Tabet, N, Livingston, G, Bentham, P, McShane, R, Burns, A, Ritchie, C, Reeves, S, Lovestone, S, Ballard, C, Noble, W, Wilcock, G & Nilforooshan, R 2020, ' Minocycline 200 mg or 400 mg versus placebo for mild Alzheimer’s disease: the MADE Phase II, three-arm RCT ', Efficacy and Mechanism Evaluation, vol. 7, no. 2, 7(2), pp. 1-45 . https://doi.org/10.3310/eme07020
Background Minocycline is an anti-inflammatory drug and protects against the toxic effects of β-amyloid in vitro and in animal models of Alzheimer’s disease. To the best of our knowledge, no randomised placebo-controlled clinical trials in patient
Autor:
Rebecca Walesby, Marion Latimer, James Galloway, Gordon K. Wilcock, Henriette Ebbesen Laidlaw, Vera Cvoro, Emma Reynish, Peter T. Donnan, Bruce Guthrie, Alasdair C Rutherford, Simona M. Hapca, Angela Pusram, Feifei Bu, Siobhan McDermott, Jennifer K. Burton
Publikováno v:
Health Services and Delivery Research, Vol 9, Iss 8 (2021)
Background Cognitive impairment is common in older people admitted to hospital, but previous research has focused on single conditions. Objective This project sits in phase 0/1 of the Medical Research Council Framework for the Development and Evaluat
Autor:
Hans J Moebius, Charles S Davis, Jiri Hardlund, Kohkan Shamsi, Ken Marek, John Storey, Peter Bentham, Giovanni B. Frisoni, Serge Gauthier, Damon Wischik, Trevor Ahearn, Luc Bracoud, Vesna Vuksanović, Jianping Jia, Karin A Kook, Claude M. Wischik, Charles R. Harrington, Gernot Riedel, John Seibyl, Roger T. Staff, Bjoern Schelter, Gordon K. Wilcock
Publikováno v:
Journal of Alzheimer's Disease, Vol. 61, No 1 (2018) pp. 435-457
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease
Background: LMTM is being developed as a treatment for AD based on inhibition of tau aggregation. Objectives: To examine the efficacy of LMTM as monotherapy in non-randomized cohort analyses as modified primary outcomes in an 18-month Phase III trial
Autor:
John Kang, Gordon K. Wilcock, Mary J. Savage, Xuemei Zhao, Donald Warden, Omar F Laterza, A. David Smith, Vladimir Svetnik
Publikováno v:
The journal of applied laboratory medicine. 5(1)
BackgroundAccurate diagnosis of Alzheimer disease (AD) involving less invasive molecular procedures and at reasonable cost is an unmet medical need. We identified a serum miRNA signature for AD that is less invasive than a measure in cerebrospinal fl
Autor:
Patrick G. Kehoe, M. Arfan Ikram, Mario Cortina-Borja, Naomi Hammond, A. David Smith, Reinhard Heun, Panos Deloukas, Rachel Barber, Yurii S. Aulchenko, Monique M.B. Breteler, Maaike Schuur, Eliecer Coto, Kristelle Brown, Cornelia M. van Duijn, Olivia Belbin, D J Lehmann, Heike Kölsch, Michael G Lehmann, Alejandro Arias-Vásquez, Gordon K. Wilcock, Donald Warden, Abderrahim Oulhaj, Ignacio Mateo, Rhian Gwilliam, Onofre Combarros, Victoria Alvarez, Kevin Morgan
Publikováno v:
BMC Medical Genetics, 11, pp. 162-162
Combarros, O, Warden, D R, Hammond, N, Cortina-Borja, M, Belbin, O, Lehmann, M G, Wilcock, G K, Brown, K, Kehoe, P G, Barber, R, Coto, E, Alvarez, V, Deloukas, P, Gwilliam, R, Heun, R, Kölsch, H, Mateo, I, Oulhaj, A, Arias-Vásquez, A, Schuur, M, Aulchenko, Y S, Ikram, M A, Breteler, M M, van Duijn, C M, Morgan, K, Smith, A D & Lehmann, D J 2010, ' The dopamine β-hydroxylase-1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project ', BMC Medical Genetics, vol. 11, no. 1, 162 . https://doi.org/10.1186/1471-2350-11-162
BMC Medical Genetics, 11, 162-162
BMC Medical Genetics, Vol 11, Iss 1, p 162 (2010)
BMC Medical Genetics, 11. BioMed Central Ltd.
BMC Medical Genetics. 2010 Nov 11;11:162
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
BMC Medical Genetics, 11(1):162. BioMed Central
BMC Medical Genetics
Combarros, O, Warden, D R, Hammond, N, Cortina-Borja, M, Belbin, O, Lehmann, M G, Wilcock, G K, Brown, K, Kehoe, P G, Barber, R, Coto, E, Alvarez, V, Deloukas, P, Gwilliam, R, Heun, R, Kölsch, H, Mateo, I, Oulhaj, A, Arias-Vásquez, A, Schuur, M, Aulchenko, Y S, Ikram, M A, Breteler, M M, van Duijn, C M, Morgan, K, Smith, A D & Lehmann, D J 2010, ' The dopamine β-hydroxylase-1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project ', BMC Medical Genetics, vol. 11, no. 1, 162 . https://doi.org/10.1186/1471-2350-11-162
BMC Medical Genetics, 11, 162-162
BMC Medical Genetics, Vol 11, Iss 1, p 162 (2010)
BMC Medical Genetics, 11. BioMed Central Ltd.
BMC Medical Genetics. 2010 Nov 11;11:162
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
BMC Medical Genetics, 11(1):162. BioMed Central
BMC Medical Genetics
Background The loss of noradrenergic neurones of the locus coeruleus is a major feature of Alzheimer's disease (AD). Dopamine β-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline. Interactions have been reported between the low-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2432dab7af8a0f7acc658f67fc6080
https://ora.ox.ac.uk/objects/uuid:013009c4-c08e-415c-87aa-4be3e41afaf4
https://ora.ox.ac.uk/objects/uuid:013009c4-c08e-415c-87aa-4be3e41afaf4
Autor:
Rowan Pentz, Gordon K. Wilcock, Palma Gubert, Adriana Ducatenzeiler, A. Claudio Cuello, M. Florencia Iulita, Sharon Christie, Lisi Flores Aguilar, Aravind Ganesh
Publikováno v:
Journal of Alzheimer's disease : JAD. 67(1)
Biomarker discovery is a major need for earlier dementia diagnosis. We evaluated a plasma signature of amyloid, metallo-proteinases (MMPs), and inflammatory markers in a cohort of at-risk individuals and individuals clinically diagnosed with probable
Autor:
Peter Passmore, Rajesh N. Kalaria, Gordon K. Wilcock, Patrick G. Kehoe, Seth Love, Marcus R. Munafò, Mika Martiskainen, Olivia Anna Skrobot, Tanja Pessi, Amy Jayne McKnight, Francesco Panza, Pekka J. Karhunen, Patrizia Mecocci, Davide Seripa, Timo Erkinjuntti
Publikováno v:
Skrobot, O A, McKnight, A J, Passmore, P A, Seripa, D, Mecocci, P, Panza, F, Kalaria, R, Wilcock, G K, Munafò, M R, Erkinjuntti, T, Karhunen, P, Pessi, T, Martiskainen, M, Love, S, Kehoe, P G 2016, ' A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort ', Journal of Alzheimer's Disease, vol. 53, no. 3, pp. 981-989 . https://doi.org/10.3233/JAD-150862
Skrobot, O A, McKnight, A J, Passmore, P A, Seripa, D, Mecocci, P, Panza, F, Kalaria, R, Wilcock, G, Munafò, M, Erkinjuntti, T, Karhunen, P, Pessi, T, Martiskainen, M, Love, S, Kehoe, P G & Genetic and Environmental Risk for Alzheimer’s disease Consortium (GERAD1) 2016, ' A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort ', Journal of Alzheimer's disease : JAD . https://doi.org/10.3233/JAD-150862
Skrobot, O A, McKnight, A J, Passmore, P A, Seripa, D, Mecocci, P, Panza, F, Kalaria, R, Wilcock, G, Munafò, M, Erkinjuntti, T, Karhunen, P, Pessi, T, Martiskainen, M, Love, S, Kehoe, P G & Genetic and Environmental Risk for Alzheimer’s disease Consortium (GERAD1) 2016, ' A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort ', Journal of Alzheimer's disease : JAD . https://doi.org/10.3233/JAD-150862
Vascular cognitive impairment (VCI), including its severe form, vascular dementia (VaD), is the second most common form of dementia. The genetic etiology of sporadic VCI remains largely unknown. We previously conducted a systematic review and meta-an