Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Gordon J. Lutz"'
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171538 (2017)
Glutamate-activated α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA-Rs) mediate the majority of excitatory neurotransmission in brain and thus are major drug targets for diseases associated with hyperexcitability or neurotoxicit
Externí odkaz:
https://doaj.org/article/9749fe1926bb4b44a6ba43562a7c6f8d
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171538 (2017)
PLoS ONE
PLoS ONE
Glutamate-activated α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA-Rs) mediate the majority of excitatory neurotransmission in brain and thus are major drug targets for diseases associated with hyperexcitability or neurotoxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7b745921f0cf3bf31d9334caf015b8
http://europepmc.org/articles/PMC5298276?pdf=render
http://europepmc.org/articles/PMC5298276?pdf=render
Publikováno v:
Developmental Neurobiology. 73:27-44
Synaptotagmin-1 (syt1) is a Ca(2+)-binding protein that functions in regulation of synaptic vesicle exocytosis at the synapse. Syt1 is expressed in many types of neurons well before synaptogenesis begins both in vivo and in vitro. To determine if exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbbc83793ebbeb17d3ad6ebb19d3aad
https://doi.org/10.1002/dneu.22033
https://doi.org/10.1002/dneu.22033
Autor:
Younghoon, Kim, Manorama, Tewari, J David, Pajerowski, Shenshen, Cai, Shamik, Sen, Jason H, Williams, Jason, Williams, Shashank R, Sirsi, Shashank, Sirsi, Gordon J, Lutz, Gordon, Lutz, Dennis E, Discher
Publikováno v:
Journal of Controlled Release. 134:132-140
siRNA and antisense oligonucleotides, AON, have similar size and negative charge and are often packaged for in vitro delivery with cationic lipids or polymers-but exposed positive charge is problematic in vivo. Here we demonstrate loading and functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2f229442095aa9a76660eea660d6e1
https://doi.org/10.1016/j.jconrel.2008.10.020
https://doi.org/10.1016/j.jconrel.2008.10.020
Autor:
Rebecca C. Schray, Jason H. Williams, Michelle L. Erney, Shashank R. Sirsi, Nicole M. Lykens, Xiangying Guan, Gordon J. Lutz
Publikováno v:
Human Gene Therapy. 19:795-806
Exon-skipping oligonucleotides (ESOs) with 2'-O-methyl modifications are promising compounds for the treatment of Duchenne muscular dystrophy (DMD). However, the usefulness of these compounds is limited by their poor delivery profile to muscle tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba42a991473e04523bdcaefdb00b3af
https://doi.org/10.1089/hum.2007.129
https://doi.org/10.1089/hum.2007.129
Publikováno v:
Molecular Therapy. 14(1):88-96
Antisense oligonucleotides (AOs) with 2-O-methyl modifications can circumvent dystrophin mutations via exon skipping and, it is hoped, can become drugs for treatment of Duchenne muscular dystrophy (DMD). However, AO-based approaches are hindered by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e462b10f1e6103f5633d2d165be3dc6
Publikováno v:
Human Gene Therapy. 16:1307-1317
Antisense oligonucleotides (AO) can facilitate dystrophin expression via targeted exon skipping in cultured cells of Duchenne muscular dystrophy (DMD) patients and in the mouse model of DMD (mdx mice). However, the lack of effective means to deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e6f4ce8c7d3d32844f5988cf5d07ee
https://doi.org/10.1089/hum.2005.16.1307
https://doi.org/10.1089/hum.2005.16.1307
Publikováno v:
Gene Therapy. 12:347-357
It is well established that mutations in specific structural elements of the motor protein myosin are directly linked to debilitating diseases involving malfunctioning striated muscle cells. A potential way to study the relationship between myosin st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e534f6e9f13dd909037ad4fd0bc247c7
https://doi.org/10.1038/sj.gt.3302411
https://doi.org/10.1038/sj.gt.3302411
Publikováno v:
Journal of Applied Physiology. 97:1803-1813
Sarcomere length and first-order diffraction line width were measured by laser diffraction during elongation of activated frog tibialis anterior muscle fiber bundles (i.e., eccentric contraction) at nominal fiber strains of 10, 25, or 35% ( n = 18) f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0586aca9e7d6a066a857b195af613f53
https://doi.org/10.1152/japplphysiol.00505.2003
https://doi.org/10.1152/japplphysiol.00505.2003
Autor:
Richard L. Lieber, Gordon J. Lutz
Publikováno v:
Microscopy Research and Technique. 50:443-457
Functional studies on isolated single anuran skeletal muscle cells represent classic experiments from which much of our understanding of muscle contraction mechanisms have been derived. Because of their superb mechanical stability when isolated, sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c271a8997f2464c30f4164272975e26b
https://doi.org/10.1002/1097-0029(20000915)50:6<443::aid-jemt3>3.0.co
https://doi.org/10.1002/1097-0029(20000915)50:6<443::aid-jemt3>3.0.co