Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Gordon J. King"'
Autor:
Yen-Hua Huang, Qingdan Du, Zhihao Jiang, Gordon J. King, Brett M. Collins, Conan K. Wang, David J. Craik
Publikováno v:
Molecules, Vol 26, Iss 18, p 5554 (2021)
Cyclotides have attracted great interest as drug design scaffolds because of their unique cyclic cystine knotted topology. They are classified into three subfamilies, among which the bracelet subfamily represents the majority and comprises the most b
Externí odkaz:
https://doaj.org/article/bf931ce588d9487d96c58271bccceb1f
Autor:
Yen-Hua Huang, Brett M. Collins, Huawu Yin, Conan K. Wang, David J. Craik, Yanfeng Gao, Gordon J. King, Xiuman Zhou
Publikováno v:
Journal of the American Chemical Society. 143:18536-18547
Peptides have potential to be developed into immune checkpoint inhibitors, but the target interfaces are difficult to inhibit. Here, we explored an approach to mimic the binding surface of PD-1 to design inhibitors. Mimicking native PD-1 resulted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4119cf337837dde7fd3a8de5c018583b
https://doi.org/10.1021/jacs.1c08132
https://doi.org/10.1021/jacs.1c08132
Autor:
Asma Rehman, Shu-Hong Hu, Zakir Tnimov, Andrew E Whitten, Gordon J King, Russell J Jarrott, Suzanne J Norwood, Kirill Alexandrov, Brett M Collins, Michelle P Christie, Jennifer L Martin
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183366 (2017)
Vesicular transport of cellular cargo requires targeted membrane fusion and formation of a SNARE protein complex that draws the two apposing fusing membranes together. Insulin-regulated delivery and fusion of glucose transporter-4 storage vesicles at
Externí odkaz:
https://doaj.org/article/b085b7d07209489292faba0427e15430
Autor:
Gordon J. King, David J. Craik, Kuok Yap, Andrew M. White, Peta J. Harvey, Guojie Wu, Ruby H. P. Law, Simon J. de Veer, Joakim E. Swedberg, Conan K. Wang, Thomas Durek
Publikováno v:
Angewandte Chemie International Edition. 59:11273-11277
Ruthenium-catalysed azide-alkyne cycloaddition (RuAAC) provides access to 1,5-disubstituted 1,2,3-triazole motifs in peptide engineering applications. However, investigation of this motif as a disulfide mimetic in cyclic peptides has been limited, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd06b0ba14d993b3cbfff990fda8f9d
https://doi.org/10.1002/anie.202003435
https://doi.org/10.1002/anie.202003435
Autor:
Zhihao Jiang, Conan K. Wang, David J. Craik, Qingdan Du, Yen-Hua Huang, Brett M. Collins, Gordon J. King
Publikováno v:
Molecules
Volume 26
Issue 18
Molecules, Vol 26, Iss 5554, p 5554 (2021)
Volume 26
Issue 18
Molecules, Vol 26, Iss 5554, p 5554 (2021)
Cyclotides have attracted great interest as drug design scaffolds because of their unique cyclic cystine knotted topology. They are classified into three subfamilies, among which the bracelet subfamily represents the majority and comprises the most b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b05924bf6d5d58be6ee32d41010eb0f
https://pubmed.ncbi.nlm.nih.gov/34577034
https://pubmed.ncbi.nlm.nih.gov/34577034
Autor:
Lakshmanane Premkumar, Begoña Heras, Andrew E. Whitten, Jennifer L. Martin, Gordon J. King, Patricia M. Walden, Maria A. Halili
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
The disulfide isomerase α-DsbA2 from Wolbachia pipientisis is unexpectedly homotrimeric and lacks the ‘shape-shifting’ conformational flexibility that defines another trimeric disulfide isomerase, ScsC from Proteus mirabilis.
Disulfide-bond
Disulfide-bond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12a9f8f731c639b56e7dd749ca080e7
https://doi.org/10.1107/s2059798318018442
https://doi.org/10.1107/s2059798318018442
Autor:
Gordon, J. King
Publikováno v:
Peace Research, 1986 Sep 01. 18(3), 23-76.
Externí odkaz:
https://www.jstor.org/stable/23609861
Autor:
Róisín M. McMahon, Santosh Panjikar, Jennifer L. Martin, Ben Vezina, Mian Chee Gor, Gordon J. King, Andrew T. Smith, Bernd H. A. Rehm
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Plantacyclin B21AG is a circular bacteriocin produced by Lactiplantibacillus plantarum B21 which displays antimicrobial activity against various Gram-positive bacteria including foodborne pathogens, Listeria monocytogenes and Clostridium perfringens.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94858f34c53d817642c3cd239104b398
https://pubmed.ncbi.nlm.nih.gov/33060678
https://pubmed.ncbi.nlm.nih.gov/33060678
Autor:
Shu-Hong Hu, Andrew E Whitten, Gordon J King, Alun Jones, Alexander F Rowland, David E James, Jennifer L Martin
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41731 (2012)
ARHGAP22 is a RhoGAP protein comprising an N-terminal PH domain, a RhoGAP domain and a C-terminal coiled-coil domain. It has recently been identified as an Akt substrate that binds 14-3-3 proteins in response to treatment with growth factors involved
Externí odkaz:
https://doaj.org/article/b9964990bcee4fa7818a316c1c2b7ca6
Autor:
Gordon J King, Kai-En Chen, Gautier Robin, Jade K Forwood, Begoña Heras, Anil S Thakur, Bostjan Kobe, Simon P Blomberg, Jennifer L Martin
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7851 (2009)
Protein crystallisation screening involves the parallel testing of large numbers of candidate conditions with the aim of identifying conditions suitable as a starting point for the production of diffraction quality crystals. Generally, condition scre
Externí odkaz:
https://doaj.org/article/008bf3fc0f97499fbc81c20ef64faf36