Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gordon J. Conard"'
Autor:
Gordon J. Conard, Steven C. Forland, Ellen Burgess, Ralph E. Cutler, Charles E. Weeks, J. M. Fox, Andrew D. Blair, Donald C. Kvam
Publikováno v:
The Journal of Clinical Pharmacology. 28:259-267
The pharmacokinetics of flecainide acetate were studied in 20 patients with varying degrees of renal impairment following a single oral dose. The patients were divided into two groups, on the basis of renal creatinine clearance (CLCR), for statistica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57a1d82206ce54a4d94d5b8fb03494c
https://doi.org/10.1002/j.1552-4604.1988.tb03142.x
https://doi.org/10.1002/j.1552-4604.1988.tb03142.x
Publikováno v:
International Journal of Pharmaceutics. 10:259-273
In this single dose study with 8 subjects, the rate and extent of theophylline absorption from 3 sustained-release formulations (Theolair-SR tablet, Slo-phyllin Gyrocaps, and an experimental SR tablet) were compared to absorption from a conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33ea24f9c03fa955d177f67e340640fe
https://doi.org/10.1016/0378-5173(82)90076-x
https://doi.org/10.1016/0378-5173(82)90076-x
Autor:
Jeanne M. Fox, Shaw F. Chang, Gordon J. Conard, Donald C. Kvam, Charles E. Weeks, Robert P. Paone, George P. Lewis
Publikováno v:
The Journal of Clinical Pharmacology. 26:27-31
The possible effect of oral flecainide acetate on steady-state digoxin levels was assessed in 15 healthy men. Each volunteer received digoxin 0.25 mg daily (8 AM) for 22 consecutive days and flecainide 200 mg bid (8 AM and 8 PM) on days 11 through 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33c3265ce43015822f9a3875b08c5a4
https://doi.org/10.1002/j.1552-4604.1986.tb02898.x
https://doi.org/10.1002/j.1552-4604.1986.tb02898.x
Autor:
Jeffrey L. Anderson, Theresa A. Johnson, Donald C. Kvam, James R. Stewart, Daniel D. Van Hamersveld, Bertram Pitt, Benjamin A. Perry, Gordon J. Conard, Shaw F. Chang
Publikováno v:
New England Journal of Medicine. 305:473-477
The antiarrhythmic efficacy and safety of oral flecainide acetate were assessed during a controlled, short-term dosage-maintenance study. Thirteen patients with chronic ventricular ectopy entered a placebo control period, and 11 with persistent, freq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4855ae95f66fdda0964f932349584376
https://doi.org/10.1056/nejm198108273050901
https://doi.org/10.1056/nejm198108273050901
Publikováno v:
Journal of Pharmaceutical Sciences. 60:1642-1646
Equilibrium dialysis was used to determine the degree of plasma protein binding of both 5,5-diphenylhydantoin and its major metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin, in man and in the rat. Binding studies show that diphenylhydantoin is exten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb03adf4d2ab4856b5de9571b1914d80
https://doi.org/10.1002/jps.2600601110
https://doi.org/10.1002/jps.2600601110
Autor:
L. Mottonen, Donald A. Berry, Shaw F. Chang, Donald C. Kvam, Gordon J. Conard, Bruce P Ekholm, Charles E. Weeks, Jordan L. Holtzman
Publikováno v:
Clinical pharmacology and therapeutics. 46(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b278a1c3951b100808620d4f3d507fd6
https://pubmed.ncbi.nlm.nih.gov/2501055
https://pubmed.ncbi.nlm.nih.gov/2501055
Autor:
Roy L. McQuinn, Ralph E. Cutler, Gordon J. Conard, A. M. Miller, S. Parish, Don C. Kvam, Steven C. Forland
Publikováno v:
Journal of clinical pharmacology. 28(8)
Study objective: To determine the pharmacokinetics of oral flecainide acetate after single and multiple doses in patients with impaired renal function. Design: Paired study of single followed by multiple oral doses. Setting: Patients enrolled in a Ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7995cef1c24cfe62be67abd61efaedc
https://pubmed.ncbi.nlm.nih.gov/3145942
https://pubmed.ncbi.nlm.nih.gov/3145942
Autor:
Henry J. Duff, Rebecca J. Maffucci, Gordon J. Conard, Dan M. Roden, Barbara S. Vesper, Raphael F. Smith, Raymond L. Woosley, Stanley B. Higgins, John A. Oates
Publikováno v:
The American journal of cardiology. 48(6)
Flecainide acetate is a new antiarrhythmic agent whose pharmacokinetics have suggested that effective therapy could be achieved with twice daily dosing. The antiarrhythmic and electrocardiographic effects of flecainide were evaluated in 11 patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e80f3b6a24e636338cc12843d771faf
https://pubmed.ncbi.nlm.nih.gov/7304461
https://pubmed.ncbi.nlm.nih.gov/7304461
Autor:
Robert E. Ober, Gordon J. Conard
Publikováno v:
The American journal of cardiology. 53(5)
After oral administration in healthy human subjects, flecainide absorption is prompt (average peak level at 3 to 4 hours) and nearly complete (at least 90%); flecainide does not appear to undergo consequential presystemic biotransformation. Oral abso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93978b7067e1bdce5f52357f67e90a1a
https://pubmed.ncbi.nlm.nih.gov/6364769
https://pubmed.ncbi.nlm.nih.gov/6364769
Publikováno v:
Journal of dental research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b1afcd050f10cdcda32b1cef210dcc
https://pubmed.ncbi.nlm.nih.gov/1055746
https://pubmed.ncbi.nlm.nih.gov/1055746