Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Gordon I. Smith"'
Autor:
Mohammad Honarvar, Julio Lobo, Caitlin Schneider, Samuel Klein, Gordon I. Smith, Rohit Loomba, Alnoor Ramji, Tarek Hassanein, Eric M. Yoshida, Emily Pang, Michael P. Curry, Nezam H. Afdhal
Publikováno v:
WFUMB Ultrasound Open, Vol 2, Iss 2, Pp 100061- (2024)
Introduction: As prevalence of patients with steatotic liver diseases increases throughout the world, it is necessary to have accurate and accessible methods to estimate liver fat content. Using quantitative ultrasound parameters, such as attenuation
Externí odkaz:
https://doaj.org/article/7de839a8c75b49dab257ace0a800fd48
Autor:
Mandy M. Chan, Sabine Daemen, Joseph W. Beals, Marina Terekhova, Bin Q. Yang, Christina F. Fu, Li He, Arick C. Park, Gordon I. Smith, Babak Razani, Kathleen Byrnes, Wandy L. Beatty, Shaina R. Eckhouse, J. Christopher Eagon, Daniel Ferguson, Brian N. Finck, Samuel Klein, Maxim N. Artyomov, Joel D. Schilling
Publikováno v:
JHEP Reports, Vol 5, Iss 11, Pp 100877- (2023)
Background & Aims: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a common complication of obesity with a hallmark feature of hepatic steatosis. Recent data from animal models of MAFLD have demonstrated substantial changes in macroph
Externí odkaz:
https://doaj.org/article/899e9858356b4c83b39c77d67e35c9a8
Autor:
Susheel K. Gunasekar, Litao Xie, Ashutosh Kumar, Juan Hong, Pratik R. Chheda, Chen Kang, David M. Kern, Chau My-Ta, Joshua Maurer, John Heebink, Eva E. Gerber, Wojciech J. Grzesik, Macaulay Elliot-Hudson, Yanhui Zhang, Phillip Key, Chaitanya A. Kulkarni, Joseph W. Beals, Gordon I. Smith, Isaac Samuel, Jessica K. Smith, Peter Nau, Yumi Imai, Ryan D. Sheldon, Eric B. Taylor, Daniel J. Lerner, Andrew W. Norris, Samuel Klein, Stephen G. Brohawn, Robert Kerns, Rajan Sah
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Type 2 diabetes is associated with insulin resistance, impaired insulin secretion and liver steatosis. Here the authors report a proof-of-concept study for small molecule SWELL1 modulators as a therapeutic approach to treat diabetes and associated li
Externí odkaz:
https://doaj.org/article/f4d1fee19c624c0a9f1b40ef56f78e04
Autor:
Yi Zhu, Na Li, Mingyang Huang, Mason Bartels, Sophie Dogné, Shangang Zhao, Xi Chen, Clair Crewe, Leon Straub, Lavanya Vishvanath, Zhuzhen Zhang, Mengle Shao, Yongjie Yang, Christy M. Gliniak, Ruth Gordillo, Gordon I. Smith, William L. Holland, Rana K. Gupta, Bingning Dong, Nathalie Caron, Yong Xu, Yucel Akgul, Samuel Klein, Philipp E. Scherer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Hyaluronan is a naturally occurring linear polysaccharide that together with collagens, enzymes, and glycoproteins forms the extracellular matrix. Here the authors show that adipose tissue overproduction of Hyaluronan reduces fat accumulation in mice
Externí odkaz:
https://doaj.org/article/d5d6f30432264ee3a4a2783133e16a29
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
Background It is unclear how excess adiposity and insulin resistance affect β cell function, insulin secretion, and insulin clearance in people with obesity.Methods We used a hyperinsulinemic-euglycemic clamp procedure and a modified oral glucose to
Externí odkaz:
https://doaj.org/article/08c03347e8d948b6ac7c26eb2de742a0
Autor:
Gordon I. Smith, Jun Yoshino, Shannon C. Kelly, Dominic N. Reeds, Adewole Okunade, Bruce W. Patterson, Samuel Klein, Bettina Mittendorfer
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 849-861 (2016)
High-protein (HP) intake during weight loss (WL) therapy is often recommended because it reduces the loss of lean tissue mass. However, HP intake could have adverse effects on metabolic function, because protein ingestion reduces postprandial insulin
Externí odkaz:
https://doaj.org/article/76d10f73415545cdabce7bead19360cc
Publikováno v:
Journal of the Endocrine Society. 7
Context The Pritikin Program, which provides intensive lifestyle therapy, has been shown to improve cardiometabolic outcomes when provided as a residential program. Objective The purpose of the present study was to conduct a short-term, randomized, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c275ce6fbd77b9e31d5bd0ab49ade76
https://doi.org/10.1210/jendso/bvad048
https://doi.org/10.1210/jendso/bvad048
Publikováno v:
JCEM Case Reports. 1
People with obesity who do not have the metabolic syndrome or components of the metabolic syndrome have been characterized as having metabolically healthy obesity (MHO). However, the existence of MHO has been questioned because people with MHO are at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36ca2161dbffff50d006abc4ad9c13cd
https://doi.org/10.1210/jcemcr/luad015
https://doi.org/10.1210/jcemcr/luad015
Autor:
Andrew LaPoint, Jason M. Singer, Daniel Ferguson, Trevor M. Shew, M. Katie Renkemeyer, Hector Palacios, Rachael Field, Mahalakshmi Shankaran, Gordon I. Smith, Jun Yoshino, Mai He, Gary J. Patti, Marc K. Hellerstein, Samuel Klein, Jonathan R. Brestoff, Brian N. Finck, Andrew J. Lutkewitte
Publikováno v:
bioRxiv
Dysfunctional adipose tissue is believed to promote the development of hepatic steatosis and systemic insulin resistance, but many of the mechanisms involved are still unclear. Lipin 1 catalyzes the conversion of phosphatidic acid to diacylglycerol (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33734f1b0a3139892daf97f77c28f2b
https://europepmc.org/articles/PMC9915639/
https://europepmc.org/articles/PMC9915639/
Autor:
Erwei Li, Luhong Wang, Daqing Wang, Jingyi Chi, Gordon I. Smith, Samuel Klein, Paul Cohen, Evan D. Rosen
Oxytocin (OXT), a nine amino acid peptide produced in the hypothalamus and released by the posterior pituitary, has well-known actions in parturition, lactation, and social behavior1, and has become an intriguing therapeutic target for diseases like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b1c08bacaa0eec7335581d945951cc4
https://doi.org/10.1101/2022.09.27.509745
https://doi.org/10.1101/2022.09.27.509745